School of Life Sciences
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Boyan Bonev

Lecturer in Biochemistry, Faculty of Medicine & Health Sciences

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Biography

antibiotics

antibiotic resistance

nuclear magnetic resonance

membrane biophysics

Expertise Summary

antibiotics

antibiotic resistance

nuclear magnetic resonance

membrane biophysics

Teaching Summary

Biophysics, Structural Biology, Physical Chemistry, Biochemistry

Research Summary

The focus of research in my group is on investigations of the molecular mechanisms, which underpin the recognition and disruption of plasma membranes by protein and peptide antibiotics and toxins.… read more

Selected Publications

Current Research

The focus of research in my group is on investigations of the molecular mechanisms, which underpin the recognition and disruption of plasma membranes by protein and peptide antibiotics and toxins. The design of effective and safe biologically active compounds relies on knowledge of the atomic details form such protein-target or peptide-target interactions. A range of biophysical techniques including modern solid state NMR, electron microscopy and neutron reflectivity is used to investigate protein-lipid, protein-protein and protein-ligand interactions, as well as the structure of peptides in their bioactive form on the target membranes.I am particularly interested in the recognition of membrane-associated bacterial cell wall intermediates by antibiotics, which inhibit bacterial cell wall biosynthesis. One such example is the interaction between bacterial lantibiotic nisin from Lactococcus lactis and its target, membrane-associated Lipid II (also targeted by vancomycin).

Past Research

Lipid phases; high-pressure NMR; toxins;

Future Research

We develop:

antibiotic systems for the control of bacteria, resistant to traditional chemotherapy;

mechanisms for rapid detection and preliminary identification of bacteria;

We investigate:

the structure and folding of membrane proteins, specifically, of bacterial outer membrane proteins;

School of Life Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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