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Matthias Brock

Assistant Professor, Faculty of Medicine & Health Sciences

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Biography

1994-1995 Basic studies in Biology at the Johannes-Guternberg University Mainz, Germany; 1995-1998 Studies of Microbiology at the Philipps University Marburg, Germany, 1997 Erasums/Sokrates exchange program with the University of Oxford, UK; 1998 Diploma in Microbiology at the Philipps University Marburg, Germany; 1998-2001 PhD student at the Phillips University Marburg, Germany; 2001 Research Associate at the Phillips University Marburg, Germany; 2001-2005 Assistant Professor at the Leibniz University Hannover, Germany; 2005 Advanced Training at the Institute Pasteur, Paris, France, 2005-2006 Group leader "Biochemistry and Physiology of Filamentous Fungi" at the Department for Molecular and Applied Microbiology at the Leibniz Institute for Natural product Research and Infection Biology, Jena, Germany; 2006-2011 Independent research group leader "Microbial Biochemistry and Physiology" at the Leibniz Institute for Natural product Research and Infection Biology, Jena, Germany; 2010 Venia Legendi at the Friedrich Schiller University Jena, Germany; 2011-2012 Head of the research group "Microbial Biochemistry and Physiology" at the Leibniz Institute for Natural product Research and Infection Biology, Jena, Germany; 2012-2015 Head of the research group "Microbial Biochemistry and Physiology" at the Friedrich Schiller University Jena, Germany; since 2015 Assistant Professor at the University of Nottingham in the Fungal Biology and Genetics Group

Expertise Summary

The following key aspects are studied in the group:

- Metabolic physiology of fungi during infection processes

- In vivo bioluminescence imaging of fungal infections

- Interactions of Aspergillus species with immune cells

- Secondary metabolite production by Aspergillus terreus

- Heterologous secondary metabolite production in Aspergillus niger

Research Summary

The group focuses on filamentous fungi and yeasts that are of medical or industrial importance. One of the research questions addressed nutritional aspects of pathogenic fungi during the infection… read more

Selected Publications

Current Research

The group focuses on filamentous fungi and yeasts that are of medical or industrial importance. One of the research questions addressed nutritional aspects of pathogenic fungi during the infection process of mammals in order to identify new antifungal drug targets. In this respect, bioluminescence imaging systems have been developed that allow in vivo imaging of fungal infections in murine infection models, which allows to study the efficacy of antifungals in therapeutic approaches. Additionally, the potential of secondary metabolite production in the filamentous fungus Aspergillus terreus is investigated. here, research not only focuses on the identification of new metabolites, but also the environmental conditions triggering metabolite production in order to increase environmental fitness of the producer. Recently, we also started to develop new heterologous expression systems in Aspergillus niger, by using secondary metabolite gene cluster elements from A. niger as molecular tools. This system allows rapid cloning and expression of secondary metabolites genes from other fungal species and leads to high yield products even from small culture volumes.

School of Life Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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