School of Life Sciences
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Susan Chan

Associate Professor in Pharmacology, Faculty of Medicine & Health Sciences

Contact

  • workRoom E34C The University of Nottingham Medical School
    Queen's Medical Centre
    Nottingham
    NG7 2UH
    UK
  • work0115 82 30150
  • fax0115 82 30081

Expertise Summary

My main research interest lies in understanding how nutrients regulate insulin secretion.

Stimulus-secretion coupling in the islet B-cell is well-researched but our knowledge remains limited in many areas with this very complex system, in which metabolism is closely tied into insulin biosynthesis and exocytosis. The research aim of the group is to generate information to provide for a richer understanding of the control of insulin secretion and thus, ultimately, for the development of new and strategically-targetted therapeutic agents to regulate the release of insulin.

More recent research interests are investigations into control of adipocyte functions (role of intracellular calcium, insulin resistance), of vascular tone (pharmacology), and of respiratory smooth muscle tone (hyperglycaemia and remodelling).

Research Techniques/Expertise

  • Isolation and manipulation of isolated islets of Langerhans
  • In vitro insulin secretion studies
  • Ligand binding
  • Protein analysis and purification

Research Interests

  • Diabetes
  • Stimulus-secretion coupling and insulin secretion
  • Imidazoline receptors and endogenous ligands
  • Receptor biochemistry and pharmacology
  • Cell signalling

Teaching Summary

Main teaching activities: human physiology, pharmacology and clinical therapeutics to Life Sciences and MPharm undergraduates and on pre-clinical Medicine degree.

  • Head of Year 3 MPharm
  • Assessment Lead for Professional Degrees (Life Sciences).
  • Lord Dearing Award for Excellence in Teaching & Learning 2016

Research Summary

Diabetes Stimulus-secretion coupling and insulin secretion Imidazoline receptors and endogenous ligands ATP-sensitive potassium channels Adrenoceptors

Recent Publications

School of Life Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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