School of Life Sciences
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Image of Dumitru Constantin-Teodosiu

Dumitru Constantin-Teodosiu

Research @ Teaching, Faculty of Medicine & Health Sciences

Contact

  • workRoom D52A The University of Nottingham Medical School
    Queen's Medical Centre
    Nottingham
    NG7 2UH
    UK
  • work0115 82 30111
  • fax0115 82 30103

Research Summary

Interests

  • My research efforts are focused at investigating the causes of fatigue in both disease state and during exercise in humans.
  • My research interest can be also viewed as an integration of in vivo functional measurements in humans with molecular signalling pathways in muscle.

Techniques

  • Measurements of human body function (respiratory and cardiovascular, strength, endurance).
  • Invasive and non-invasive measurements of human energy metabolism in whole body, tissue or single fibre level.
  • Measurements of muscle function and biochemistry
  • Measurements of human blood/tissue (heart, skeletal muscle, liver) metabolites.
  • RT-PCR, real time PCR (TaqMan probes, SYBR Green I fluorescence quantitation).
  • Protein chemistry (separation and quantification); one- and two-dimensional electrophoresis, Western blot.
  • Spectrophotometry (UV and visible), Fluorophotometry, Bio-luminescence.
  • Assays of cellular high-energy phosphates compounds in tissue and single fibre.
  • High performance liquid chromatography.
  • Radioisotopic and radio-immunoassays.
  • Enzyme kinetic assays.
  • Measurements of â-oxidation, glycogenolysis, glycolysis, tricarboxylic acid cycle, and electron transport-chain intermediaries.
  • Isolation and monitoring mitochondrial activity (O2 uptake, ATP production).
  • Rat hindlimb perfusion model

Recent Publications

Future Research

Research on skeletal and cardiac energy metabolism in health, disease and exercise.

School of Life Sciences

University of Nottingham
Medical School
Queen's Medical Centre
Nottingham NG7 2UH

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