Scientist
After graduation in Biomedicine at Umeå
University, I did a Ph.D (between 1999-2004) on patho-adaptation of Helicobacter
pylori, under the supervision of Professor Thomas Borén, Dept. of Odontology,
Faculty of Medicine, Umeå University, Sweden. I then moved to Nottingham
and joined MBIG in September 2005. My previous work on Helicobacter pylori led
to the identification of the adhesin SabA and its host legend, sLex/a antigen.
Orihuela C, Mahdavi J, Thornton J, Mann B, Wooldridge KG, Abouseada N, Oldfield NJ, Self T, Ala'Aldeen DAA, Tuomanen EI. (2009) Laminin receptor initiates contact of bacterial with the blood brain barrier in experimental meningitis models. J Clin Invest. 2009 119:1638-1646. (joint first author) Paper highlighted in Nature [Bacterial break-in. (2009) Nature. 459: p487: 28 May 2009]
Lindén S, Mahdavi J, Semino-Mora C, Olsen C, Carlstedt I, Borén T, Dubois A. (2008). Role of ABO secretor status in mucosal innate immunity and H. pylori infection. PLoS Pathog. 4(1):e2.
Horlock C, Shakib F, Mahdavi J, Jones NS, Sewell HF, Ghaemmaghami AM. (2007). Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics. Genome Biol. 8(3):R30.
Richens J, Fairclough L, Ghaemmaghami AM, Mahdavi J, Shakib F, Sewell HF. (2007). The detection of ADAM8 protein on cells of the human immune system and the demonstration of its expression on peripheral blood B cells, dendritic cells and monocyte subsets. Immunobiology. 212(1):29-38.
Walz A, Odenbreit S, Mahdavi J, Borén T, Ruhl S. (2005). Identification and characterization of binding properties of Helicobacter pylori by glycoconjugate arrays. Glycobiology. 15(7):700-8.
Aspholm-Hurtig M, Dailide G, Lahmann M, Kalia A, Ilver D, Roche N, Vikström S, Sjöström R, Lindén S, Bäckström A, Lundberg C, Arnqvist A, Mahdavi J, Nilsson UJ, Velapatiño B, Gilman RH, Gerhard M, Alarcon T, López-Brea M, Nakazawa T, Fox JG, Correa P, Dominguez-Bello MG, Perez-Perez GI, Blaser MJ, Normark S, Carlstedt I, Oscarson S, Teneberg S, Berg DE, Borén T. (2004). Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. Science. 305(5683):519-22.
Lindén S, Mahdavi J, Hedenbro J, Borén T, Carlstedt I. (2004). Effects of pH on Helicobacter pylori binding to human gastric mucins: identification of binding to non-MUC5AC mucins. Biochem J.1;384(Pt 2):263-70.
Van de Bovenkamp JH, Mahdavi J, Korteland-Van Male AM, Büller HA, Einerhand
AW, Borén T, Dekker J. (2003).The MUC5AC glycoprotein is the primary
receptor for Helicobacter pylori in the human stomach.
Helicobacter. 8(5):521-32.
Mahdavi J, Borén T, Vandenbroucke-Grauls C, Appelmelk BJ. (2003). Limited role of lipopolysaccharide Lewis antigens in adherence of Helicobacter pylori to the human gastric epithelium. Infect Immun. 71(5):2876-80.
Mahdavi J, Sondén B, Hurtig M, Olfat FO, Forsberg L, Roche N, Angstrom J, Larsson T, Teneberg S, Karlsson KA, Altraja S, Wadström T, Kersulyte D, Berg DE, Dubois A, Petersson C, Magnusson KE, Norberg T, Lindh F, Lundskog BB, Arnqvist A, Hammarström L, Borén T. (2002). Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation. Science. 26;297(5581):573-8.
Petersson C, Larsson B, Mahdavi J, Borén T, Magnusson KE. (2000). A new method to visualize the Helicobacter pylori-associated Lewis(b)-binding adhesin utilizing SDS-digested freeze-fracture replica labeling. J Histochem Cytochem. 48(6):877-83.
Sandström O, Mahdavi J, el-Salhy M. (1999). Age-related changes in antral endocrine cells in mice. Histol Histopathol. 14(1):31-6.
El-Salhy M, Mahdavi J, Norrgård O. (1998). Colonic endocrine cells in patients with carcinoma of the colon. Eur J Gastroenterol Hepatol.10(6):517-22.
Sandström O, Mahdavi J, El-Salhy M. (1998). Effect of ageing on colonic endocrine cell population in mouse. Gerontology. 44(6):324-30.
el-Salhy M, Mahdavi J. (1997). Image analysis of the duodenal endocrine cells
in mice with particular regard to optical densitometry.Ups J Med Sci. 1997;1
Molecular
Bacteriology
and Immunology Group
Institute of Infection, Immunity
and Inflammation
Centre for Biomolecular Sciences
University of Nottingham
University Park
Nottingham NG7 2RD
United Kingdom
Tel:
(44) 115 823 0749
Fax: (44) 115 823 0759
email: jafar.mahdavi@nottingham.ac.uk
Molecular Bacteriology and
Immunology Group
Division
of Microbiology & Infectious Diseases
University
of Nottingham