Dr
Neil Oldfield---BSc, PhD
Senior Research Fellow
Molecular Bacteriology & Immunology Group
My main area of interest is in the pathogenesis of Gram-negative bacterial infections, especially Neisseria meningitidis, Campylobacter jejuni and Actinobacillus pleuropneumoniae. Since joining MBIG in 2001, my work has focused on defining the roles of several bacterial virulence factors produced by these species and investigating novel vaccines to prevent disease. Areas of specific interest include type V secreted proteins, moon-lighting proteins and the dynamics of meningococcal carriage.
Teaching
I am co-convener of the ‘Introduction to Clinical Bacteriology’ module of the MSc in Clinical Sciences (Infection Sciences). In addition, I contribute practical classes, lectures and tutorials to the MSc Course in Clinical Microbiology
Selected publications
Javed MA, Cawthraw SA, Baig A, Li J, McNally A, Oldfield NJ, Newell DG & Manning G. (2012) Cj1136 is required for LOS biosynthesis, hyperinvasion and chick colonization by Campylobacter jejuni. Infect. Immun. In Press.
Ala’Aldeen DAA, Oldfield NJ, Bidmos FA, Abouseada NM, Ahmed NW, Turner DPJ, Neal KR & Bayliss CD. (2011). Carriage of meningococci by university students, United Kingdom. Emerg. Infect. Dis. 17, 1762-1763.
Bidmos FA, Neal KR, Oldfield NJ, Turner DPJ, Ala’Aldeen DAA & Bayliss CD. (2011) Rapid clonal expansion, persistence and clonal replacement of meningococcal carriage isolates in a 2008 university student cohort. J. Clin. Microbiol. 49, 506-512.
Tunio SA, Oldfield NJ, Ala'Aldeen DAA, Wooldridge KG & Turner DPJ. (2010) The role of glyceraldehyde 3-phosphate dehydrogenase (GapA-1) in Neisseria meningitidis adherence to human cells. BMC Microbiol. 10, 280.
Ala’Aldeen DAA*, Flint M*, Oldfield NJ*, Omer SA, McNeil LK, Jiang Q, Murphy E, Giardina PC, Novikova EG, Dodge IL, Bayliss CD, Turner DPJ, Neal KR, Hoiseth SK, Jansen KU & Anderson AS. (2010) Human antibody responses to the meningococcal factor H binding protein (LP2086) during invasive disease, colonization and carriage. Vaccine 28, 7667-75. *Contributed equally to this work.
Tunio SA, Oldfield NJ, Berry A, Ala'Aldeen DAA, Wooldridge KG & Turner DPJ. (2010) The moonlighting protein fructose-1, 6-bisphosphate aldolase of Neisseria meningitidis: surface localization and role in host cell adhesion. Mol. Microbiol. 76, 605-615.
Oldfield NJ, Worrall KE, Rycroft AN, Ali T, Wooldridge KG & Ala'Aldeen DAA. (2009) AasP autotransporter protein of Actinobacillus pleuropneumoniae does not protect pigs against homologous challenge. Vaccine 27, 5278–83.
Orihuela C, Mahdavi J, Thornton J, Mann B, Wooldridge, KG, Abouseada N, Oldfield NJ, Self T, Ala'Aldeen DAA & Tuomanen EI. (2009) Laminin receptor initiates contact of bacteria with the blood brain barrier. J. Clin. Invest. 119, 1638-46.
Bacterial break-in: Research Highlights. (2009) Nature 459, p487: 28 May 2009 (highlight of the above JCI paper)
Oldfield NJ & KG Wooldridge (2009) Protein secretion and the pathogenesis of Campylobacter jejuni. In: Bacterial secreted proteins. K. G. Wooldridge (Ed). Caister Academic Press, pp. 299-312.
Ali T*, Oldfield NJ*, Wooldridge KG, Turner DP & Ala'Aldeen DAA. (2008) Functional characterization of AasP, a maturation protease autotransporter protein of Actinobacillus pleuropneumoniae. Infect. Immun. 76, 5608-14. *Contributed equally to this work
Oldfield NJ*, Donovan EA*, Worrall KE, Wooldridge KG, Langford PR, Rycroft AN & Ala’Aldeen DAA. (2008) Identification and characterization of novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae. Vaccine 26, 1942-54. *Contributed equally to this work
Oldfield NJ, Bland SJ, Taraktsoglou M, Dos Ramos FJ, Robinson K, Wooldridge KG & Ala’Aldeen DAA (2007) T-cell stimulating protein A (TspA) of Neisseria meningitidis is required for optimal adhesion to human cells. Cell. Microbiol. 9, 463-78.
Ashgar SA*, Oldfield NJ*, Wooldridge KG, Jones MA, Irving GJ, Turner DPJ & Ala’Aldeen DAA. (2007) CapA, an autotransporter protein of Campylobacter jejuni, mediates association to human epithelial cells and colonization of the chicken gut. J. Bacteriol. 189, 1856-65. *Contributed equally to this work
Oldfield NJ, Moran AP, Millar LA, Prendergast MM & Ketley JM. (2002) Characterization of the Campylobacter jejuni heptosyltransferase II gene, waaF, provides genetic evidence that extra-cellular polysaccharide is lipid A-core independent. J. Bact. 184, 2100-07.
Fry BN, Oldfield NJ, Korolik V, Coloe PJ & Ketley JM. (2000) The genetics of lipopolysaccharide biosynthesis in Campylobacter. In Campylobacter, p381-403. Edited by I. Nachamkin & M. Blaser. ASM Press, Washington, DC.
Wood AC, Oldfield NJ, O’Dwyer CA & Ketley JM. (1999) Cloning, mutation and distribution of a putative LPS biosynthesis locus in Campylobacter jejuni. Microbiology 145, 379-88.
Oldfield NJ, Wood AC & Ketley JM. (1998) Analysis and distribution of Campylobacter LOS/LPS biosynthesis genes. In: Campylobacter, Helicobacter and Related Organisms. A. L. Lastovica, D. G. Newell & E. E. Lastovica (eds). Cape Town: Institute of Child Health, Red Cross Children's Hospital, pp. 322-26.
Contact details
Senior Research Fellow
Molecular Bacteriology and Immunology Group
Centre for Biomolecular Sciences
University of Nottingham
University Park
Nottingham
NG7 2RD
Tel: (44) 115 823 2527
Fax: (44) 115 846 8002
email: neil.oldfield@nottingham.ac.uk
Molecular Bacteriology and
Immunology Group
Division of Microbiology
& Infectious Diseases
University of Nottingham