Molecular Bacteriology & Immunology Group

Selected publications

Ibraz-Pavon AB, MacLennan J, Andrews NJ, Gray SJ, Urwin R, Clarke SC, Walker AM, Evans MR, Kroll JS, Neal KR, Ala’Aldeen DAA, Crook DW, Cann K, Harrison S, Cunningaham R, Baxter D, Kaczmarski E, McCarthy ND, Jolley KA, Cameron JC, Stuart JM and Maiden MCJ. 2011. Changes In Serogroup And Genotype Prevalence Among Carried Meningococci In The United Kingdom During Vaccine Implementation. The J Infect Dis. 204, 1046-53

Ala'Aldeen DAA, Oldfield NJ, Bidmos FA, Abouseada NM, Ahmed NW, Turner DPJ, et al. (2011) Carriage of meningococci by university students, United Kingdom. Emerg Infect Dis. 17:1762-3

Tauseef I, Harrison OB, Wooldridge KG, Feavers IM, Neal KR, Gray SJ, Kriz P, Turner DPJ, Ala’Aldeen DAA, Maiden MCJ, and Bayliss CB.  (2011)  Influence of the Combination and Phase Variation Status of the Haemoglobin Receptors, HmbR and HpuAB, on Meningococcal Virulence. Microbiology. 157:1446-56 .

Bidmos F, Neal KR, Oldfield NJ, Turner DPJ, Ala’Aldeen DAA and Bayliss CD (2011). Rapid Clonal Expansion, Persistence and Clonal Replacement of Meningococcal Carriage Isolates in a 2008 University Student Cohort. J Clin Microbiol. 49, 506-512.

Tunio SA, Oldfield NJ, Ala’Aldeen DAA, Wooldridge KG and Turner DPJ (2010). The role of glyceraldehyde 3-phosphate dehydrogenase (GapA-1) in Neisseria meningitidis adherence to human cells.  BMC Microbiology. 10: 280-

Ala’Aldeen DAA, Flint M, Oldfield NJ, Omer SA, McNeil LK, Jiang Q, Murphy E, Giardina PC, Novikova EG, Dodge IL, Bayliss CD, Turner DPJ, Neal KR, Hoiseth SK, Jansen KU and Anderson AS.  (2010) Human antibody responses to the meningococcal factor H binding protein (LP2086) during invasive disease, colonization and carriage. Vaccine, 28: 7667-6675.

Oldfield NJ, Worrall KE, Rycroft AN, Ali T, Wooldridge and Ala'Aldeen DAA (2009) AasP autotransporter protein of Actinobacillus pleuropneumoniae does not protect pigs against homologous challenge. Vaccine 27:5278-83

Tunio SA, Oldfield NJ, Berry A, Ala'Aldeen DAA, Wooldridge KG & Turner DPJ (2010) The moonlighting protein fructose-1, 6-bisphosphate aldolase of Neisseria meningitidis : surface localization and role in host cell adhesion. Mol. Microbiol. 76 , 605-615.

Oldfield NJ, Worrall KE, Rycroft AN, Ali T, Wooldridge KG, Ala'Aldeen DAA (2009) AasP autotransporter protein of Actinobacillus pleuropneumoniae does not protect pigs against homologous challenge. Vaccine 27 , 5278–5283.

Orihuela C, Mahdavi J, Thornton J, Mann B, Wooldridge KG, Abouseada N, Oldfield NJ, Self T, Ala'Aldeen DAA, Tuomanen EI. (2009) Laminin receptor initiates contact of bacterial with the blood brain barrier in experimental meningitis models. J Clin Invest. 2009 119:1638-1646. (joint senior author). Paper highlighted in Nature [Bacterial break-in. (2009) Nature. 459: p487: 28 May 2009]

Li Y, Wooldridge KG, Javed MA, Tang C and Ala'Aldeen DAA (2009) Secreted proteins of Neisseria meningitidis protect mice against infection. Vaccine. 27:2320-5

Spence PR, Wright V, Ala’Aldeen DAA, Turner DPJ, Wooldridge KG Wooldridge and James R (2008) Validation of a Virulence and Epidemiology (VirEp) DNA microarray for Staphylococcus aureus. J Clin Microbiol. 46, 1620-1627..

Ali T, Oldfield NJ, Wooldridge KG, Turner DPJ, and Ala'Aldeen DAA (2008) Functional characterization of AasP, a maturation protease autotransporter protein of Actinobacillus pleuropneumoniae. Infect. Immun. 76, 5608-5614.

Oldfield NJ, Donovan EA†, Worrall KE, Wooldridge KG, Langford PR, Rycroft AN & Ala'Aldeen DAA (2008). Identification and characterization of novel antigenic vaccine candidates of Actinobacillus pleuropneumoniae. Vaccine 26, 1942-1954.

Maiden MCJ, Ibarz-Pavón AB, Urwin R, Gray SJ, Andrews NJ, Clarke SC, Walker AM, Evans MR, Kroll JS, Neal KR, Ala'Aldeen DAA, Crook DW, Cann K, Harrison S, Cunningham R, Baxter D, Kaczmarski E, MacLennan J, Cameron JC, Stuart JM. (2007) Impact of meningococcal serogroup C conjugate vaccines on carriage and herd immunity. J Infect Dis; In press

Ashgar SSA, Oldfield NJ, Wooldridge KG, Jones MA, Irving GJ, Turner DPJ and Ala’Aldeen DAA (2007). CapA, an Autotransporter Protein of Campylobacter jejuni, Mediates Association with Human Epithelial Cells and Colonization of the Chicken Gut. J. Bacteriol. 189: 1856–1865.

Oldfield NJ, Bland SJ, Taraktsoglou M, Dos-Ramos F, Robinson K, Wooldridge KG and Ala’Aldeen DAA (2007) T-cell stimulating protein a (TspA) of Neisseria meningitidis is required for optimal adhesion to human cells. Cellular Microbiol. 9, 463–478.

Turner DPJ, Marietou AG. Johnston L, Ho KKL, Rogers AJ, Wooldridge KG Ala’Aldeen DAA (2006). Characterisation of MspA - an immunogenic autotransporter protein mediating adhesion to epithelial and endothelial cells in Neisseria meningitides. Infect Immun, 74 ,2957–2964

Wooldridge KG, Kizil M , Wells DB & Ala'Aldeen DAA (2005) Unusual Genetic Organization of a Functional Type I Protein Secretion System in Neisseria meningitidis. Infect Immun. 73, 5554-5567

Robinson K, Wooldridge KG, Wells D, Dos Ramos F, Hasan A, Todd I, Robins A, James R, Ala'Aldeen DAA (2005). T-Cell-Stimulating Protein A Elicits Immune Responses during Meningococcal Carriage and Human Disease. Infect Immun. 73, 4684-4693

Ala’Aldeen DAA, Dangerfield P, Benbow E, Barer M, Irving W. (2005). Teaching Microbiology to Medical Students-debate. Microbiology Today. Aug. p134-135.

Henderson IR, Navarro-Garcia F, Desvaux M Fernandez R and Ala'Aldeen DAA (2004). Type V secretion pathway: the autotransporter story. MMBR. 68: 692-744.

Robinson K, Taraktsoglou K, Rowe K, Wooldridge KG, Ala'Aldeen DAA (2004). Secreted proteins from Neisseria meningitidis mediate differential human gene expression and immune activation. Cellular Microbiology. 6: 927-938.

Constantin D, Cordenier A, Robinson K, Ala'Aldeen DAA, Murphy S (2004) Neisseria meningitidis induced death of cerebrovascular endothelium: mechanisms triggering transcriptional activation of inducible nitric oxide synthase". J Neurochem. 89; 1166 1174.

Goulding JN, Stanley J, Olver W, Neal KR, Ala'Aldeen DAA and Arnold C (2003), Independent subsets of amplified fragments from the genome of Neisseria meningitidis identify the same invasive clones of ET37 and ET5 J Med Microbiol, 52, 151-154

Bebb JR, Bailey-Flitter N, Ala'Aldeen DAA and Atherton JA (2003) Mastic gum has no effect on Helicobacter pylori load in vivo. J Antimicrob Chemother 52, 522-523

Loughlin MF, Ala'Aldeen DAA and Jenks P (2003) Monotherapy with mastic does not eradicate Helicobacter pylori infection from mice. J Antimicrob Chemother. 51,367-71

Turner DPJ, Wooldridge KG, Ala'Aldeen DAA. (2002) Autotransported serine protease A(AspA) of Neisseria meningitidis: an immunogenic, surface-exposed outer-membrane and secreted protein. Infect Immun, 70, 4447-4461.

Maiden et al (2002) Carriage of serogroup C meningococci 1 year after meningococcal C conjugate polysaccharide vaccinatino. Lancet 359. p1829-30

Ala'Aldeen DAA. (2002) A non-mulitresistant community MRSA exposes its genome. Lancet 359. 1791-2

Constantin D, DAA Ala'Aldeen, S Murphy (2002) Transcriptional activation of nitric oxide synthase-2, and NO-induced cell death, in mouse cerebrovascular endothelium exposed to Neisseria meningitidis. J Neurochem 81; 270-276.

Robinson K, KR Neal, C Howard, J Stockton, K Atkinson, E Scarth, J Moran, A Robins, I Todd, E Kaczmarski, S Gray, I Muscat, R Slack and DAA Ala'Aldeen. (2002). Characterisation of humoral and cellular immune responses elicited by meningococcal carriage. Infect Immun 70; 1301-1309.

Ala'Aldeen DAA. (2001) Risk of deliberately induced anthrax outbreak. Lancet 358. p1387

Abdel Hadi H, Wooldridge KG, Robinson K, Ala’Aldeen DAA. (2001) Identification and Characterisation of App: an Immunogenic Autotransporter Protein of Neisseria meningitidis.  Mol Microbiol. 41, 611-624.

Ala'Aldeen DAA and H Grundmann (2001) Unveiling of genetic basis of resistance of S. aureus to antibiotics. Lancet, 357; 1218-1219.

Turner PC, CE. Thomas, I Stojiljkovic, C Elkins, G Kizel, DAA Ala'Aldeen, and P. F. Sparling (2001). Neisserial TonB-dependent outer-membrane proteins: detection, regulation and distribution of three putative candidates identified from the genome sequences.  Microbiology 147: 1277-1290

Wells D, Teigh P, Wooldridge KG, Robinson K, Ala’Aldeen DAA (2001). Differential gene expression during meningeal-meningococcal interaction:  evaluation for self-defence and early release of cytokines and chemokines. Infect Immun, 69; 2718-2722.

Goulding JN, Hookey JV, Stanley J, Olver W, Neal KR, Ala’Aldeen DAA, Arnold C. (2000).  Fluorescent amplified-fragment length polymorphism genotyping of Neisseria meningitidis identfies clones associated with invasive disease.  J Clin Microbiol; 38, 4580-4585.

Ait-Tahar K, KG Wooldridge, DPJ Turner, M Atta, I Todd, DAA Ala'Aldeen (2000) Auto-transporter A (AutA) protein of Neisseria meningitidis: a potent CD4+ T-cell and B-cell stimulating antigen detected by expression cloning. Mol Microbiol. 37, 1094-1105.

Ala'Aldeen DAA , KR Neal, K Ait-Tahar, JS Nguyen-Van-Tam, A English, TJ Falla, PM Hawkey, RCB Slack (2000). Dynamics of meningococcal long-term carriage among University students and their implications on mass-vaccination. J Clin Microbiol. 38:2311-2316.

Neal KR, JS Nguyen-Van-Tam, R Madeley, K Ait-Tahar, M Vale, RCB Slack, DAA Ala'Aldeen. (2000) Changing carriage rate of Neisseria meningitidis amongst university students during the first week of term. cross sectional study. BMJ 320: 846-849.

Kizil G, I Todd , M Atta, SP Borriello, K Ait-Tahar and DAA Ala'Aldeen. (1999)Identification and characterisation of TspA, a major CD4+ T-cell and B-cell stimulating Neisseria-specific antigen. Infect Immun. 67, 3533-3541.

Neal KR, JS Nguyen-Van-Tam, RCB Slack, EB Kaczmarski, A White, DAA Ala'Aldeen. (1999) Seven week interval between acquisition of a meningococcus and the onset of invasive disease. Epidemiol Infect. 123: 507-9.