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Andy Green

Assistant Professor, Faculty of Medicine & Health Sciences

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Biography

I have a longstanding research interest and track record in classification of breast cancer, diagnosis of breast disease and evaluation of prognostic factors in breast cancer.

I successfully defended my PhD 'Regulatory factors in human breast: cytokines and 17beta-hydroxysteroid dehydrogenase' in 1997 at the University of Hull. My first post-doctoral position was at the MRC Toxicology Unit in Leicester which focussed on the differential effects of Selective Estrogen Receptor Modulators (SERMs). I have been at the University of Nottingham since 2003 focussing on the the molecular pathology of breast cancer.

Expertise Summary

My main research expertise is within breast cancer molecular pathology using techniques such as immunohistochemistry, tissue microarrays (TMAs), laser microdissection and gene expression profiling,

Teaching Summary

I have been module convenor for two modules (Principles and Practice of Histology (CP44H)/Principles and Practice of Cytology (C74CCD) on a new major distant learning course as part of the… read more

Research Summary

My main research focus is the exploration of the hypothesis that a novel classification of breast cancer based on phenotypic and molecular genetic characteristics will provide a more robust system… read more

Selected Publications

My principle role is research focused and involves the leadership, development, planning, management and practical implementation of individual and collaborative research projects. Furthermore, I am directly involved in development of concepts, ideas and strategies, including the principal investigator role, preparation and submission of successful research grant applications. My role also includes leadership, management and administrative duties and to provide knowledge transfer and guidance to staff/students. Additionally I am involved in preparation of research publications as lead or contributing author resulting in a sustained publication track record and national reputation in this field.

I have been module convenor for two modules (Principles and Practice of Histology (CP44H)/Principles and Practice of Cytology (C74CCD) on a new major distant learning course as part of the Government/NHS Modernising Scientific Careers strategy which is a UK-wide education and training strategy for the whole healthcare science workforce in the NHS and associated bodies. The MSc Clinical Sciences course has resulted in an enhancement-based approach to teaching by providing distant learning in terms of podcasted lectures and online assessments. The role of module convenor has incorporated curriculum and lecture/module development, recoding podcasts, setting and marking exams.

Since 2006, I have regularly taught several lectures on the BMedSci (CLS), BSc Healthcare Science, MSc Oncology, MSc Clinical Genetics courses.

I have a sustained record in the design and marking of assessments acting as Internal assessor for BMedSci, MSc Clinical Sciences, MSc Oncology research projects and performing vivas. Also marking exams and acting as a moderator.

I also act as a Pastoral tutor for BMedSci and MSc Oncology students.

Current Research

My main research focus is the exploration of the hypothesis that a novel classification of breast cancer based on phenotypic and molecular genetic characteristics will provide a more robust system for classification and therapeutic decision-making. As a consequence modern classification of breast cancer should be based on combined morphological, phenotypic (protein expression) and molecular genetic characteristics. This will provide a more robust system for classification and therapeutic decision-making and allow identification of novel therapeutic targets.

I'm currently completing the development and validation of the Nottingham Prognostic Index Plus (NPI+) which is a clinical decision making tool in breast cancer (BC) aiming to provide improved patient outcome stratification superior to the traditional methods.

Past Research

I have sustained international publication record on breast cancer pathology research since 1995 and have contributed to over 200 peer reviewed publications in journals including those of high impact: NATURE, NATURE MEDICINE, JOURNAL OF CLINICAL ONCOLOGY, and PLoS MEDICINE.

Future Research

Future research directions will include the investigation of key enzymes in the proline-glutamine regulatory axis in triple negative breast cancer to improve our insight into its role in tumour pathobiology and patient outcome in the aggressive breast cancer subtype.

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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