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Brian Thomson

Consultant Physician and Clinical Academic, Faculty of Medicine & Health Sciences

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Biography

Dr Brian Thomson qualified in medicine from the University of Edinburgh and trained in Edinburgh, London and Cambridge before becoming Associate Professor and Honorary Consultant in Nottingham. He has held an MRC Training Fellowship in the National Institute for Medical Research in London and Laboratory of Molecular Biology in Cambridge and an MRC Clinician Scientist Fellowship in the Department of Medicine in Cambridge, and was awarded a PhD in Molecular Virology in 1992. Dr Thomson is the founder and Director of the Nottingham Health Science Biobank and was Director of Research and Innovation for Nottingham University Hospitals from 2009 until December 2015. Dr Thomson is currently Director of the NHSE/Genomics England Ltd 100,000 Genome Project in Nottingham and a member of the East of England Genomic Medicine Centre. Dr Thomson's principle research interests are the pathogenesis of chronic inflammatory disease of the liver, with a focus on the pathogenesis and clinical management of viral hepatitis. He has a major interest in developing biobanking and linked data platforms for stratified medicine. In this capacity, Dr Thomson is Co-I for the MRC Nottingham Molecular Pathology Node, with a remit to develop new diagnostic assays and biomarkers for chronic inflammatory disease of the liver, and is co-founder and Co-I of the national MRC/UKCRC Tissue Directory and Resource Centre as resource for stratified medicine. Dr Thomson is a member of the Nottingham Biomedical Research Centre and currently holds more that £6M in research funding as both Co-I and PI, the majority of which is from the MRC and NIHR.

Expertise Summary

molecular virology

biobanking, linked data and computational analysis for stratified medicine

genomic medicine

Teaching Summary

I teach undergraduate medical students, BSc and MSc students with good feedback.

I am co-lead for the student elective period and sit on the UK Medical Schools Elective Council. I provide lectures and tutorials on elective safety and global health and personally meet all students who propose to visit countries with high infection risks. I am a member of the Transition to Practice (TTP) Module Management Committee and have written the Infectious Disease Policy for Medical Student Guidance, incorporating guidance provided by the Department of Health and UK Medical Schools Council.

I deliver 36 lectures and 16 tutorials per year on infectious disease and clinical medicine to undergraduate students which receive very good feedback. These groups include:

  • pre-clinical medical students (5 contact hours)
  • Graduate Entry Medicine (year 3) (2 contact hours)
  • clinical medical students (years 3 and 5) (6 contact hours)
  • Microbiology BSc students (3 contact hours)
  • MSc Molecular Microbiology students (16 contact hours)
  • MSc Clinical Microbiology students (16 contact hours)
  • MSC Clinical Oncology (4 contact hours)

I set examination questions for all of these courses.

In order to improve my teaching, learning and assessment skills I have registered for Medwise, an on-line 10 credit module designed for health care professionals, and academics who have responsibility for undergraduate and post-graduate medical and health science education. Medwise is hosted by the School of Medicine and delivered in partnership with the Royal College of General Practitioners and Health Education England in the East Midlands.

Research Summary

My principle research interests are the pathogenesis of infection with hepatitis viruses and clinical management of chronic viral hepatitis, with a focus the development of new models of care to… read more

Recent Publications

Current Research

My principle research interests are the pathogenesis of infection with hepatitis viruses and clinical management of chronic viral hepatitis, with a focus the development of new models of care to maximize patient engagement. I am currently developing innovative shared care models as part of the national commitment to eradicate hepatitis C virus infection. I have initiated an MRC funded project in partnership with Indonesia on the molecular pathogenesis of hepatitis B virus infection, with a focus on the dynamics and consequences of viral escape from vaccination and the development of new diagnostic tests. I am co-Investigator for the MRC Nottingham Molecular Pathology Node with a remit to develop new assays for the stratification of HBV infection and biomarkers for the progression of chronic viral hepatitis and cirrhosis.

I am founder of the Nottingham Health Sciences Biobank as a biosample and data platform for translational and stratified medicine in Nottingham, and am co-founder of the national MRC/UKCRC Tissue Directory and Resource Centre as a national 'virtual' resource for stratified medicine. Consistent with my major interest in genomic/stratified medicine, I am the Director of the NHSE and Genomics England Ltd 100,000 Genome Project in Nottingham.

I currently co-supervise five PhD studentships in the fields of viral hepatitis (3) and genomic medicine (2).

Recent Research Grants

April 2017: 3 years. MRC. The prevalence and phenotype of hepatitis B virus vaccine escape variants propagated by mother to child transmission in Indonesia. £595,010 BJT PI

July 2015: 4 years. MRC Nottingham Molecular Pathology Node. New biomarkers and molecular diagnostics tests for chronic inflammatory conditions including those of the liver. £2.40 M BJT Co-I

January 2015: 3 years. Breast Cancer Campaign. To establish a Breast Cancer Campaign Tissue Bank in Nottingham. £1,559,785. BJT Co-I

2014: 3 years. MRC. UKCRC Tissue Directory and Co-ordination Centre. £987,450. BJT Co-I

May 2013: 2 years. Breast Cancer Campaign. Ellis I, Thomson BJ. To establish a Breast Cancer Campaign Tissue Bank in Nottingham. £641,827. BJT Co-I

November 2013: 3 years. NIHR Policy Research Programme. Partner Institutions: University of Nottingham; University of Bristol. Evaluation of interventions designed to increase diagnosis and treatment of patients with hepatitis C virus infection in primary care and drug treatment settings. NIHR Policy Research Programme. £1.15M BJT Co-I

November 2011: 1 NIHR Capital Grant. Thomson BJ. An integrated clinical research centre (Nottingham Health Science Partners). £1.32 M. BJT PI

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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