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Stewart Martin

Professor of Cancer and Radiation Biology, Faculty of Medicine & Health Sciences

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Biography

Stewart Martin studied in Glasgow for a BSc (Hons) in Applied Biology (1984) before obtaining an MSc in Radiation Biophysics from the University of St Andrews (1986). He conducted research at the Gray Laboratory (now the Gray Cancer Institute) in London, obtaining his PhD in Radiation Biology from St Bartholomew's Medical College, University of London (1990). After postdoctoral research at Colorado State University (with Prof Mort Elkind), and Columbia University, New York (with Prof Eric Hall), he returned to the UK to take up a post at the University of Nottingham, Department of Clinical Oncology. He was appointed as a lecturer in 1997, obtained a PGCAP (from the University of Nottingham) in 2000, was promoted to Senior Lecturer/Associate Professor in 2004 then Associate Professor/Reader. He was promoted to Professor of Cancer and Radiation Biology in 2016.

Stewart set up an MSc course in Oncology in 1997 and was the course director from its inception until 2012; he also heads the Translational & Radiation Biology Research (TRBR) Group at the University of Nottingham that was awarded 'Research team of the year, 2012' by the Breast Cancer Campaign. The TRBR group runs a cabinet irradiation facility (X-rays) as a central resource that is available to internal or external users interested in conducting radiation biology research.

His current research interests focus in three main areas: REDOX metabolism in cancer; lymphatic cell biology/cancer metastasis and radiation biology. Recent topics of attention are the mechanism of action of novel anticancer agents for the treatment of ovarian, breast, brain and pancreatic cancer; Redox regulation in ovarian, breast, brain and pancreatic cancer; The calpain and calpastatin system; Regulation of lymphovascular invasion and metastasis in cancer; Inflammatory regulation of lymphatic cell biology; and Prognostic and predictive biomarkers in cancer. Stewart collaborates with a number of research groups, academic and industrial, in the UK and across the EU and USA as well as with groups locally in Nottingham. He has published various research articles and book chapters and edited 'Methods in Molecular Medicine: Angiogenesis Protocols' (Humana Press), that was published in 2009, with the third edition published in 2016.

Stewart was a member, and Secretary, of the British Institute of Radiology's Radiation and Cancer Biology Committee (2002-2012) and served as member of the executive committee of the British Association for Cancer Research 2001-2007, as well as its Treasurer (2002-2007). He served as member of Senate of the University of Nottingham 2001-2004 and was a member of Trent Regional Oncology Education Committee (1998-2012). He is member of the Scientific Advisory Board of Breast Cancer Now and was a member of the advisory committee for the Breast Cancer Campaign (2007-2012). He is a member of The Open University's Life and Biomolecular Sciences Research Degree Management Group (from February 2003), and was a member (2008-2014) of the Examining Board of the Royal College of Radiologists (Faculty of Clinical Oncology, First FRCR examination). He is a member of the National Cancer Research Institute (NCRI) Clinical and Translational Radiotherapy Research Working Group (CTRad) - Workstream 1 (Science Base) June 2012 - June 2017. He is a Trustee of the LH Gray Memorial Trust (2016-2022).

Stewart is a Fellow of the Higher Education Academy (FHEA), of the Royal Society of Biology (FRSB), and of the Royal College of Pathologists (FRCPath). He was awarded Honorary membership of the Royal College of Radiologists (Hon MRCR) in 2015.

He has examined over 40 PhD dissertations and conducted vivas at various institutes around the UK. He was an external examiner to the MSc in Cancer Therapeutics at Barts and The London School of Medicine and Dentistry, Queen Mary, University of London (2009 - 2012), the MRes in Oncology at the University of Manchester (2010 - 2013) and MSc programs in Molecular Medicine, and Molecular Medicine & Cancer Research at Brunel University London (2012 - 2017). He is currently external examiner to the the MSc in Cancer at University College London (2013 - current). Stewart has also evaluated a number of MSc programs at the University of Liverpool and University of Sheffield.

He is Senior Editor (Radiobiology) for the British Journal of Radiology (having acted as an Associate Editor 2010-2015) and has organised various national and international research meetings and conferences on topics such as tumour angiogenesis, advances in radiobiology/radiotherapy and redox systems in health and disease.

Expertise Summary

Breast Cancer; Ovarian Cancer; Pancreatic Cancer; Brain Cancer (Glioblastoma)

Experimental Cancer Biology - In vitro Cell and Molecular Biology;

Immunohistochemistry and Histopathology

Radiotherapy & Radiation Biology

Chemotherapy and Drug Interactions (Drug-Radiation Interactions)

Lymphatic Biology - Cancer Metastasis

Calpains & Calpastatin

Research Summary

Research interest falls into three main areas: REDOX metabolism in cancer; Lymphatic cell biology/cancer metastasis and Radiation Biology.

Recent topics of attention are:

  • The mechanism of action of novel anticancer agents for the treatment of breast, brain (Glioblastoma), ovarian and pancreatic cancer;
  • Prognostic and predictive biomarkers (radiotherapeutic and chemotherapeutic response);
  • Lymphatic dissemination in breast cancer and melanoma.
  • Mechanism of action of novel anticancer agents (redox homeostasis modulators) for the treatment of breast, brain, ovarian and pancreatic cancer (2D and 3D in vitro models using normal and malignant epithelial cells);
  • Interactions between novel anticancer agents and radiation (pre-clinical in vitro radiation biology)
  • The calpain and calpastatin system;
  • Regulation of lymphovascular invasion and metastasis in cancer (characterisation of novel genes; role of inflammatory factors and macrophage in regulating tumour metastasis);

Selected Publications

Past Research

Radiation-induced mutagenesis (Colorado State University, USA) and oncogenesis (Columbia University, New York). Vascular Biology / Tumour Angiogenesis (University of Nottingham).

Future Research

Translational Cancer Research,

Angiogenesis,

Lymphangiogenesis and Cancer Metastasis,

Redox Metabolism,

Radiation Biology,

Characerisation of Novel Anticancer Agents,

Combinational Therapies (Drug-Radiation Interactions)

Calpains & Calpastatin.

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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