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Fiona Broughton-Pipkin

Emeritus Professor of Perinatal Physiology, Faculty of Medicine & Health Sciences

Contact

  • workRoom 1-609, Department of Obstetrics & Gynaecology Department of Obstetrics and Gynaecology
    Nottingham City Hospital
    Hucknall Road
    Nottingham
    NG5 1PB
    UK
  • work0115 823 1892
  • fax0115 823 1908

Research Summary

My main research interests are: the pathophysiology of the hypertensive diseases of pregnancy; the renin-angiotensin system in pregnancy; the use of transabdominal fetal heart rate monitoring in the… read more

Recent Publications

  • POUNTAIN,S, BROUGHTON PIPKIN,F and HUNTER,M, 2009. The ontogeny of components of the renin-angiotensin system in the porcine fetal ovary. Animal reproduction science.
  • WRIGHT, H. and BROUGHTON PIPKIN, F., 2009. Pomegranates ( Punica granatum) kiwifruit ( Actinidia deliciosa) and blood pressure: a pilot study In: Proceedings of The Nutrition Society, Nottingham, UK, July 2008. Volume 67, E418
  • PIJACKA, W., LUCK, M.R., HUNTER, M. and BROUGHTON PIPKIN, F., 2009. Does the renin-angiotensin system (RAS) have a role in embryo development? In: Fertility 2009. (In Press.)
  • GURUNG, V., WILLIAMSON, C., CHAPPELL, L., CHAMBERS, J., BRILEY, A., BROUGHTON PIPKIN, F. and THORNTON, J., 2009. Pilot study for a trial of ursodeoxycholic acid and/or early delivery for obstetric cholestasis. BMC Pregnancy and Childbirth. 9(1), 19

Current Research

My main research interests are: the pathophysiology of the hypertensive diseases of pregnancy; the renin-angiotensin system in pregnancy; the use of transabdominal fetal heart rate monitoring in the last three months of pregnancy, and the effect of smoking on it.

The hypertensive diseases of pregnancy: I have been working in this area since coming to Nottingham, and have just been presented with the Chesley Award of the International Society for the Study of Hypertension in Pregnancy (ISSHP), at the 2012 international meeting of the Society in Geneva. ("The Chesley Award is given to a member of the Society in recognition of her/his sustained and substantial contribution to research in preeclampsia, not only for her/his work but also for encouraging the work of others.")

Hypertension in pregnancy can be gestational hypertension, pre-eclampsia (PE) or essential hypertension +/- superimposed PE. Pre-eclampsia is associated with maternal multi-organ dysfunction, affects 2-7% of all pregnancies and is one of the leading causes of maternal and perinatal morbidity and mortality, both in the UK and world-wide. As well as investigating the underlying causes of PE, from a basic and applied science perspective, my group have also been, for some years, following-up women and their babies who have been exposed to the disease. It is increasingly recognized that women who suffered from gestational hypertension or PE are at considerably greater risk of the early development of cardiovascular, renal, metabolic, cerebrovascular and ischaemic heart disease in later life. We are acknowledged to have one of the most comprehensive early follow-up datasets of women who had hypertension in pregnancy, and a uniquely-detailed 2-year follow-up of the babies of such women. I was the Chief Investigator of the BHF-funded Genetics of Pre-Eclampsia (GOPEC) study, and am also a member of the InterPregGen consortium (EU funding of €5.96 million), which is managed from Nottingham (Dr Linda Morgan).

The group: (Nottingham) Professor Fiona Broughton Pipkin, Dr Pamela Loughna, Dr Amanda Green, Dr Anna Roberts (from October 2012), Dr Lesia Kurlak, Dr Alastair Ferraro (Collaborators) Dr Hiten Mistry, Dr Kate Bramham (KCL), Dr Jason Waugh (Newcastle), Professor Markus Mohaupt (Berne, Switzerland)

The renin-angiotensin system (RAS) in pregnancy: We are studying the potential rôle of the RAS in very early placentation, together with assessment of its systemic impact. It is now known that the redox balance markedly influences the capacity of renin to generate angiotensin I from angiotensinogen, and angiotensin II (AngII) exerts much of its vasoconstrictor effect by the generation of reactive oxygen species. Placentation occurs at very low oxygen tensions, and we have increasing evidence of potential involvement of the RAS and possible pathways involved. We have also applied for grant funding to study the renal RAS in pregnancy (Australian collaboration; see below); this links in with our work on hypertension in pregnancy. Our interest in antioxidant capacity in pregnancy links to the rôle of selenium deficiency, and a developing collaboration with the University of East Anglia in relation to selenium soil enrichment in Malawi.

The group: (Nottingham) Professor Fiona Broughton Pipkin, Dr Lesia Kurlak, Professor Dave Barrett. (Collaborators) Dr Hiten Mistry, Dr Kate Bramham (KCL), Professor Robin Carrell's group, CIMR, Cambridge; Professor Graham Burton's group (Centre for Trophoblast Research, Cambridge), Professor Eugenie Lumber's group (University of Newcastle, New South Wales, Australia), Dr Helena Strevens (University of Lund, Sweden).

Transabdominal fetal heart rate (FHR) monitoring: Using the AN24 transabdominal FHR monitor, we are able to study factors affecting the FHR and its variability while the mother is at home under normal conditions. To do this, we work directly with Professor Barrie Hayes-Gill, Professor of Electronic Systems and Medical Devices, founder of Monica plc, a University of Nottingham spin-out company. We have been able to show deleterious, dose-dependent effects of smoking on FHR variability very clearly, and are now following this up. We hope to be able to study the fetal e.c.g. transabdominally as well, but this is technically a considerable challenge.

The group: Professor Fiona Broughton Pipkin, Dr Pamela Loughna, Professor Barrie Hayes-Gill, Dr Habiba Kapaya.

(Updated: July 2012)

  • POUNTAIN,S, BROUGHTON PIPKIN,F and HUNTER,M, 2009. The ontogeny of components of the renin-angiotensin system in the porcine fetal ovary. Animal reproduction science.
  • WRIGHT, H. and BROUGHTON PIPKIN, F., 2009. Pomegranates ( Punica granatum) kiwifruit ( Actinidia deliciosa) and blood pressure: a pilot study In: Proceedings of The Nutrition Society, Nottingham, UK, July 2008. Volume 67, E418
  • PIJACKA, W., LUCK, M.R., HUNTER, M. and BROUGHTON PIPKIN, F., 2009. Does the renin-angiotensin system (RAS) have a role in embryo development? In: Fertility 2009. (In Press.)
  • GURUNG, V., WILLIAMSON, C., CHAPPELL, L., CHAMBERS, J., BRILEY, A., BROUGHTON PIPKIN, F. and THORNTON, J., 2009. Pilot study for a trial of ursodeoxycholic acid and/or early delivery for obstetric cholestasis. BMC Pregnancy and Childbirth. 9(1), 19
  • THE GOPEC CONSORTIUM (CORRESPONDING AUTHOR: F BROUGHTON PIPKIN), 2008. Smoking in moderate/severe pre-eclampsia worsens pregnancy outcome, but smoking cessation limits the damage. Hypertension. 51(4), 1042-6
  • WILSON, L., BERNSTEIN, K. and BROUGHTON PIPKIN, F., 2008. Studies of the placental renin angiotensin system (RAS) in wild type and angiotensin converting enzyme (ACE) knockout mice (Abstract) Reproductive Sciences. 15(2 - Suppl), 200A
  • SUBRAMANIAN, V., MARSTERS, P., ARGENTESI, G. and BROUGHTON PIPKIN, F., 2008. An In Vitro Demonstration of the Antihypertensive Effects of Kiwifruit Extracts Hypertension. 52(4), e118 (In Press.)
  • MISTRY, H., WILLIAMS, P. J., RAMSAY, M. M., SYMONDS, M. E. and BROUGHTON PIPKIN, F., 2008. Differences in placental glutathione peroxidases in normal and pre-eclamptic pregnancies (Abstract) Reproductive Sciences. 15(2 -Suppl), 66A
  • WILLIAMS, P.J., MISTRY, H. and BROUGHTON PIPKIN, F., 2008. Placental expression of angiotensin 3-8 (Ang IV) in normal pregnancy (NP) and pre-eclampsia (PE) (Abstract) Reproductive Sciences. 15(2 - Suppl), 288A
  • MISTRY, H.D., WILSON, V., RAMSAY, M.M., SYMONDS, M.E. and BROUGHTON PIPKIN, F., 2008. Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies Hypertension. 52(5), 881-888
  • THE GENETICS OF PRE-ECLAMPSIA (GOPEC) CONSORTIUM., 2007. Babies, pre-eclamptic mothers and grandparents: a three-generation phenotyping study Journal of Hypertension. 25(4), 849-854
  • ASKIE, L.M., DULEY, L., HENDERSON-SMART, D.J. and STEWART, L.A. ON BEHALF OF THE PARIS COLLABORATIVE GROUP, 2007. Antiplatelet agents for prevention of pre-eclampsia: a meta-analysis of individual patient data The Lancet. 369(9575), 1791-1798
  • DISSANAYAKE, V.H., TOWER, C., BRODERICK, A., STOCKER, L.J., SENEVIRATNE, H.R., JAYASEKARA, R.W., KALSHEKER, N., BROUGHTON PIPKIN, F. and MORGAN, L., 2007. Polymorphism in the epidermal growth factor gene is associated with birthweight in Sinhalese and white Western Europeans. Molecular Human Reproduction. 13(6), 425-429
  • BROUGHTON PIPKIN, F. and MORGAN, L, 2007. Genetics of Pre-eclampsia. In: DOMINICZAK, A.F. & CONNELL, J.M., ed., Genetics of Hypertension 24. Edinburgh: Elsevier. 79-100
  • BROUGHTON PIPKIN, F, 2007. Maternal Physiology.. In: EDMONDS, D.K., ed., Dewhurst's Textbook of Obstetrics and Gynaecology, 7th Edition 7th ed. Oxford, Blackwell Publishing. 10-18
  • DISSANAYAKE,V.H., SAMARASINGHE,H.D., MORGAN,L., JAYASEKARA,R.W., SENEVIRATNE,H.R. and BROUGHTON PIPKIN,F., 2007. Morbidity and mortality associated with pre-eclampsia at two tertiary care hospitals in Sri Lanka. Journal of Obstetrics and Gynaecology Research. 33(1), 56-62
  • MISTRY, H., WILSON, V., RAMSAY, M. M., BROUGHTON PIPKIN, F. and SYMONDS, M. E., 2007. Differences in serum selenium concentrations between normal and pre-eclamptic human pregnancies In: The Physiological Society. Proc Physiol Soc 6, C7
  • BROUGHTON PIPKIN, F, 2007. Animal Research. In: O'BRIEN, P.M.S. and BROUGHTON PIPKIN, F, eds., Introduction to Research Methodology for Specialists and Trainees 2nd ed. London: RCOG. 113-120 (In Press.)
  • MISTRY, H., WILSON, V., RAMSAY, M., BROUGHTON PIPKIN, F. and SYMONDS, M.E, 2007. Differences in serum selenium concentrations between normal and pre-eclamptic human pregnancies (Abstract) Journal of Physiology. (In Press.)
  • BROUGHTON PIPKIN, F., 2007. The renin-angiotensin system in pre-eclampsia. In: LYALL, F. and BELFORT, M., eds., Pre-eclampsia:Etiology and Clinical Practice 1st ed. Cambridge University Press. 78-91
  • AFOLABI, B.B., OLADIPO, O.O., ABUDU, O.O., AKANMU, A.S., SOFOLA, O.A. and BROUGHTON PIPKIN, F, 2007. Plasma volume and osmolalities in pregnant women with sickle cell disorder (Abstract) British Journal of Obstetrics & Gynaecology. (In Press.)
  • O'BRIEN, P.M.S. and BROUGHTON PIPKIN, F, eds., 2007. Introduction to Research Methodology for Specialists and Trainees 2nd ed. London: RCOG.
  • BROUGHTON PIPKIN, F, 2007. The renin-angiotensin system in pre-eclampsia.. In: LYALL, F. and BELFORT, M, eds., Pre-eclampsia:Aetiology and Clinical Practice Cambridge: Cambridge University Press. 78-91 (In Press.)
  • CHANRACHAKUL, B., WARREN, A. Y., SHAW, R. W., BROUGHTON PIPKIN, F. and KHAN, R. N., 2006. Compartmentation, function and expression of L-type calcium channel in human myometrium (Abstract) Journal of The Society for Gynaecological Investigation. 13(2), 9
  • CHANRACHAKUL, B., BROUGHTON PIPKIN, F., WARREN, A.Y., ARULKUMARAN, S. and KHAN, R.N., 2005. Progesterone enhances the tocolytic effect of ritodrine in isolated pregnant human myometrium American Journal of Obstetrics and Gynecology. 192(2), 458-463
  • THE GOPEC CONSORTIUM, 2005. Disentangling fetal and maternal susceptibility for pre-eclampsia: a British multicenter candidate-gene study American Journal of Human Genetics. 77(1), 127-131
  • CHANRACHAKUL, B., SHAW, R.W., BROUGHTON PIPKIN, F. and KHAN, R.N, 2005. Colocalisation between the large conductance calcium-activated potassium channel, L-type calcium channel, and alpha2 adrenergic receptor, with caveolin in pregnant human myometrial cells. (Abstract) Journal of Physiology. PC58
  • CHANRACHAKUL, B., WARREN, A.Y., BROUGHTON PIPKIN, F. and KHAN, R.N, 2005. Isoproterenol modulates calcium (Ca2+):activated potassium (K+) channels in pregnant human myometrium through beta2 adrenergic receptors. (Abstract) Journal of Obstetrics and Gynaecology. 21(Suppl 1), S62
  • CHANRACHAKUL, B., WARREN, A.Y., BROUGHTON PIPKIN, F. and KHAN, R.N, 2005. Activation of BKCa channels by isoproterenol in pregnant human myometrium through b2-adrenergic receptors. (Abstract) Journal of The Society for Gynaecological Investigation. 12(2), 287A
  • MARSTERS, P., DHAWANBAJAJ, A., HARRIS, C., WEISZ, N., CAMPBELL, B.K., CAMPBELL, B.K. and BROUGHTON PIPKIN,F, 2005. Components of the renin-angiotensin system (RAS) are present in the bovine pre-implantation embryo. (Abstract) Journal of The Society for Gynaecological Investigation. 12 Suppl,((2)), 105A
  • AL KADI, H., NASRAT, H. and BROUGHTON PIPKIN, F, 2005. Longitudinal study of the renin-angiotensin system (RAS), prostacyclin and thromboxane in first trimester human pregnancy. (Abstract) Journal of The Society for Gynaecological Investigation. 12(2), 278A
  • ROY, C., BROUGHTON PIPKIN, F. and WAUGH, J, 2005. A case control study of neonatal proteinuria following pre-eclampsia (PE). (Abstract) Early Human Development. 81(8), 712
  • PLUMMER, S., TOWER, C., ALONSO, P., MORGAN, L., BAKER, P., BROUGHTON-PIPKIN, F. and KALSHEKER, N., 2004. Haplotypes of the angiotensin II receptor genes AGTR1 and AGTR2 in women with normotensive pregnancy and women with preeclampsia Human Mutation. 24(1), 14-20
  • CHANRACHAKUL, B., BROUGHTON PIPKIN, F. and KHAN, R.N., 2004. Contribution of coupling between human myometrial ß2-adrenoreceptor and the BKCa channel to uterine quiescence American Journal of Physiology : Cell Physiology. 287(6), C1747-C1752
  • CHANRACHAKUL, B., BROUGHTON PIPKIN, F. and KHAN, R.N, 2004. The large conductance calcium-activated potassium channel (BKCa) and the beta2 adrenergic receptor (AR): a direct link to uterine relaxation. Physiology News. 55, 22-23
  • POUNTAIN, S.J., BLACKMORE, L., BROUGHTON PIPKIN, F. and HUNTER, M.G, 2004. The Abundance and Localisation of the AT1 and AT2 Receptor Proteins in the Porcine Fetal Ovary. (Abstract) In: Gordon Research Conference.
  • DISSANAYAKE, V.H., MORGAN, L.J., BROUGHTON PIPKIN, F., VATHANAN, V., PREMARATNE, S., JAYASEKARA, R.W. and SENEVIRATNE, H.R, 2004. The urine protein heat coagulation test - a useful screening test for proteinuria in pregnancy in developing countries: a method validation study British Journal of Obstetrics and Gynaecology. 111(5), 491-494
  • BROUGHTON PIPKIN, F, 2004. Uric acid, endothelial dysfunction and pre-eclampsia. Journal of Hypertension. 22(2), 237-9
  • ROY, C., WAUGH, J., BOSIO, P., STEVENSON, T. and BROUGHTON PIPKIN, F, 2004. A controlled prospective study of neonatal anthropometric parameters following pre-eclampsia (PE) (Abstract) Journal of The Society for Gynaecological Investigation. 11, 356A
  • DISSANAYAKE,V.H., MORGAN,L., BROUGHTON PIPKIN,F., JAYASEKARA,R.W., SENEVIRATNE,H.R. and KALSHEKER,N, 2004. A study of the association of transforming growth factor alpha polymorphisms and pre-eclampsia. (Abstract) Journal of The Society for Gynaecological Investigation. 11((2) Suppl), 257A
  • BISPHAM, J., GOPALAKRISHNAN, G.S., DANDREA, J., WILSON, V., BUDGE, H., KEISLER, D.H., BROUGHTON PIPKIN, F., STEPHENSON, T. and SYMONDS, M.E., 2003. Maternal endocrine adaptation throughout pregnancy to nutritional manipulation : consequences for maternal plasma leptin and cortisol and the programming of fetal adipose tissue development Endocrinology. 144(8), 3575-3585
  • CHANRACHAKUL, B., TURNER, A., MATHAROO-BALL, B., BROUGHTON PIPKIN, F., ARULKUMARAN, S. and KHAN, R.N., 2003. Colocalization and expression of ß2-adrenergic receptor and large conductance calcium-activated potassium channel in human myometrium Journal of Physiology. 551P, C8
  • CHANRACHAKUL, B, MATHAROO-BALL, B, TURNER, A, ROBINSON, G, BROUGHTON-PIPKIN, F, ARULKUMARAN, S and KHAN, R. N., 2003. Reduced expression of immunoreactive ß2-adrenergic receptor protein in human myometrium with labor Journal of Clinical Endocrinology and Metabolism. 88(10), 4997-5001
  • CHANRACHAKUL, B., MATHAROO-BALL, B., TURNER, A., ROBINSON, G., BROUGHTON PIPKIN, F., ARULKUMARAN, S. and KHAN, R.N., 2003. Immunolocalization and protein expression of the alpha subunit of the large-conductance calcium-activated potassium channel in human myometrium Reproduction. 126(1), 43-48
  • CHANRACHAKUL, B., MATHROO-BALL, B., TURNER, A., ROBINSON, G., ARULKUMARAN, S., BROUGHTON PIPKIN, F. and KHAN, R.N, 2003. ABSTRACT: Localisation and expression of a-subnuit of the large conductance potassium channel in human myometrium. Journal of Obstetrics and Gynaecology, Canada. 28((Suppl 1)), S53-S54
  • CHANRACHAKUL, B., MATHROO-BALL, B.TURNER, A., ROBINSON, G., BROUGHTON PIPKIN, F., ARULKUMARAN, S. and KHAN, R.N, 2003. ABSTRACT: Expression of b2-adrenoreceptors in pregnant women with and without labour. Journal of The Society for Gynaecological Investigation. 10(2), 190A
  • DISSANAYAKE, V. H. W., MORGAN, L., BROUGHTON PIPKIN, F., JAYASEKARA, R. W., SENEVIRATNE, H. R. and KALSHEKER, N., 2003. A study of the association between Epidermal Growth Factor (EGF) polymorphisms and Pre-eclampsia Journal of Medical Genetics. 40(Suppl 1), 368
  • ZAINOL, J., ROBINSON, G. and BROUGHTON PIPKIN, F, 2003. ABSTRACT: Expression of angiotensin II type 2 receptor in human placenta. Journal of Physiology. 547P, C54
  • DANDREA, J., COOPER, S., RAMSAY, M.M., KELLER-WOODS, M., BROUGHTON PIPKIN, F., SYMONDS, M. E. and STEPHENSON, T., 2002. The effects of pregnancy and maternal nutrition on the maternal renin-angiotensin system in sheep Experimental Physiology. 87(3), 353-360
  • CHANRACHAKUL, B., TURNER, A., MATHAROO-BALL, B., BROUGHTON PIPKIN, F., POUNTAIN, S. and HUNTER, M.G, 2002. ABSTRACT: AT1 receptor, AT2 receptor, renin and angiotensinogen mRNA in the porcine fetal ovary. Reproduction. Abstract series 29, 21
  • DISSANAYAKE, V.H., MORGAN, L., KALSHEKER, N., BAKER, P.N. and BROUGHTON PIPKIN, F, 2002. ABSTRACT: The MTHFR 677C>T polymorphism is not associated with pre-eclampsia in women in Nottingham. Hypertension in Pregnancy. 21(Suppl 1), 122
  • SHUTTLEWORTH, G., HUNTER, M.G, ROBINSON, G. and BROUGHTON PIPKIN, F., 2002. Immunocytochemical localization of angiotensin II receptor subtypes 1 and 2 in the porcine fetal, prepubertal and postpubertal ovary. Journal of Anatomy. 201(3), 267-74
  • SHUTTLEWORTH, G, BROUGHTON PIPKIN, F and HUNTER, M G, 2002. In vitro development of pig preantral follicles cultured in a serum-free medium and the effect of angiotensin II. Reproduction. 123(6), 807-18
  • MYHILL, D., LOBO, D.N., ALLISON, S.P. and BROUGHTON PIPKIN, F, 2002. ABSTRACT: The effect of blood volume expansion on the renin-angiotensin system (RAS). A randomised, double-blind cross-over study. Hypertension in Pregnancy. 21(Suppl 1), 19
  • BROUGHTON PIPKIN, F, 2002. Use of ACE inhibitors in the horse Equine Veterinary Education. 14, 302-303
  • BROUGHTON PIPKIN, FIONA, 2002. Relationship between size at birth and hypertension: problems and perspectives. Journal of Hypertension. 20(4), 569-71
  • MYHILL, D., BROUGHTON PIPKIN, F. and HAMPTON, J, 2002. ABSTRACT: The effect of an angiotensin II Type 1 receptor blocker (Losartan) on middle cerebral artery blood velocity: Gender-related differences. Journal of The Society for Gynaecological Investigation. 9(Suppl 1), 302A
  • SHUTTLEWORTH, G., BROUGHTON PIPKIN, F. and HUNTER, M.G, 2002. ABSTRACT: Effect of angiotensin II and receptor antagonists on porcine preantral ovarian follicles cultured in serum-free media Biology of Reproduction. 66(Suppl 1), 70
  • SHUTTLEWORTH, G, HUNTER, M G and BROUGHTON PIPKIN, F, 2001. Autoradiographic determination of angiotensin II receptors in prepubertal and postpubertal pig ovarian tissue. Reproduction. 122(5), 701-10
  • BROUGHTON PIPKIN, F., 2001. Maternal physiology in pregnancy. In: CHAMBERLAIN, G. and STEER, P.J., eds., Turnbull's Obstetrics 3rd ed. Churchill Livingstone, Edinburgh. 71-91
  • MYHILL, D. and BROUGHTON PIPKIN, F, 2001. The middle cerebral artery and changes in circulation during the menstrual cycle. (Abstract) Journal of Obstetrics and Gynaecology.. 21(Supp 1), S41
  • BROUGHTON PIPKIN, F, 2001. Risk factors for preeclampsia. New England Journal of Medicine. 344(12), 925-6
  • MYHILL, D., HAMPTON, J. and BROUGHTON PIPKIN, F, 2001. The effects of losartan on the cerebral circulation during the menstrual cycle. (Abstract) Journal of the Renin Angiotensin Aldosterone System. 2(1), 50
  • MYHILL, D., BROUGHTON PIPKIN, F. and HAMPTON, J, 2001. The effect of angiotensin II antagonism on sodium, potassium, urea and creatinine concentrations during the menstrual cycle. (Abstract) Journal of the Renin Angiotensin Aldosterone System. 2(1), 66
  • FORHEAD, A.J., BROUGHTON PIPKIN, F., TAYLOR, P.M., BAKER, K., BALOUZET, V., GIUSSANI, D.A. and FOWDEN, A, 2001. Developmental changes in blood pressure and the renin-angiotensin system in pony fetuses during the second half of gestation Journal of Reproduction and Fertility. Supplement. 56, 693-703
  • BRACKLEY, K. J., RAMSAY, M. M., BROUGHTON PIPKIN, F. and RUBIN, P. C., 2000. The maternal cerebral circulation in pre-eclampsia: investigations using Laplace transform analysis of Doppler waveforms British Journal of Obstetrics and Gynaecology. 107(4), 492-500
  • MORGAN, L., CRAWSHAW, S., BAKER, P. N., BROUGHTON PIPKIN, F. and KALSHEKER, N., 2000. Polymorphism in oestrogen response element associated with variation in plasma angiotensin concentrations in healthy pregnant women Journal of Hypertension. 18(5), 553-558
  • BROUGHTON PIPKIN, F, 2000. Letter: The white coat effect in hypertensive pregnancy: much ado about nothing? BJOG. 107(1), 143
  • BROUGHTON PIPKIN, F and ROBERTS, J M, 2000. Hypertension in pregnancy. Journal of Human Hypertension. 14(10-11), 705-24
  • BROUGHTON PIPKIN, F, 2000. The development of fetal physiology over the twentieth century: contribution to obstetric practice.. In: O'BRIEN, P.M.S., ed., The Yearbook of Obstetrics and Gynaecology 8. RCOG Press.
  • SHUTTLEWORTH, G., BROUGHTON PIPKIN, F. and HUNTER, M.G, 2000. Abstract; Immunocytochemical localization of angiotensin II receptors in the porcine ovary Journal of Reproduction and Fertility: Abstract series. 25, 200 (In Press.)
  • FORHEAD, A J, BROUGHTON PIPKIN, F and FOWDEN, A L, 2000. Effect of cortisol on blood pressure and the renin-angiotensin system in fetal sheep during late gestation. Journal of Physiology. 526(1), 167-76
  • AL KADI, H,, NASRAT, H. and BROUGHTON PIPKIN, F., 2000. A sequential study of the renin-angiotensin system (RAS) during the first trimester of human pregnancy (Abstract) Hypertension in Pregnancy. 19(1), 141
  • BRACKLEY, K. J., RAMSAY, M. M., BROUGHTON PIPKIN, F. and RUBIN, P. C., 1999. The effect of the menstrual cycle on human cerebral blood flow: studies using Doppler ultrasound Ultrasound in Obstetrics & Gynecology. 14(1), 52-57
  • MORGAN, L., CRAWSHAW, S., BAKER, P. N., BROUGHTON PIPKIN, F. and KALSHEKER, N., 1999. Maternal and fetal angiotensinogen gene allele sharing in pre-eclampsia British Journal of Obstetrics and Gynaecology. 106(3), 244-251
  • MORGAN, L., FOSTER, F., HAYMAN, R., CRAWSHAW, S., BAKER, P. N., BROUGHTON PIPKIN, F. and KALSHEKER, N., 1999. Angiotensin-converting enzyme insertion-deletion polymorphism in normotensive and pre-eclamptic pregnancies Journal of Hypertension. 17(6), 765-768
  • COOPER, A C, ROBINSON, G, VINSON, G P, CHEUNG, W T and BROUGHTON PIPKIN, F, 1999. The localization and expression of the renin-angiotensin system in the human placenta throughout pregnancy. Placenta. 20(5-6), 467-74
  • SHUTTLEWORTH, G., BROUGHTONPIPKIN, F. and HUNTER, M.G, 1999. Autoradiographic study of angiotensin II receptors in the porcine ovary Journal of Reproduction and Fertility: Abstract Series 23. 65
  • BROUGHTON PIPKIN,F, 1999. How a thesis or dissertation is assessed or examined. In: O'BRIEN, P.M.S. and BROUGHTON PIPKIN, F, eds., Introduction to Research Methodology for Specialists and Trainees London: RCOG Press. 248-253
  • BROUGHTON PIPKIN, F, 1999. What is the place of genetics in the pathogenesis of pre-eclampsia? Biology of the Neonate. 76(6), 325-30
  • BROUGHTON PIPKIN,F, 1999. Animal Research. In: O'BRIEN, P.M.S. and BROUGHTON PIPKIN, F, eds., Introduction to Research Methodology for Specialists and Trainees London: RCOG Press. 118-123 (In Press.)
  • COOPER, A.C. and BROUGHTON PIPKIN,F, 1999. The effect of angiotensin II on eicosanoid release from first trimester and term human cytotrophoblast cultures (Abstract) In: British-Dutch meeting of the International Society for the Study of Hypertension in Pregnancy. 43
  • BROUGHTON PIPKIN,F, 1999. Fetal growth and physiology. In: EDMONDS, D.K., ed., Dewhurst's Textbook of Obstetrics and Gynaecology for Postgraduates 6th ed. Oxford: Blackwell Science. 104-112
  • BROCKELSBY, J.C., HAYMAN, R.G., ANTHONY, F.W., BROUGHTON PIPKIN,F. and BAKER, P.N., 1999. Concentrations of vascular endothelial growth factor (VEGF) correlate with both blood pressure and relaxation to bradykinin in an ex vivo model of pre-eclampsia. (Abstract) In: British-Dutch meeting of the International Society for the Study of Hypertension in Pregnancy. 48
  • O'BRIEN, P.M.S. and BROUGHTON PIPKIN, F, eds., 1999. Introduction to Research Methodology for Specialists and Trainees London: RCOG Press.
  • MORGAN, L., CRAWSHAW, S., BAKER, P. N., BROOKFIELD, J. F. Y., BROUGHTON PIPKIN, F. and KALSHEKER, N., 1998. Distortion of maternal-fetal angiotensin II type 1 receptor allele transmission in pre-eclampsia Journal of Medical Genetics. 35(8), 632-636
  • BRACKLEY, K. J., RAMSAY, M. M., BROUGHTON PIPKIN, F. and RUBIN, P. C., 1998. A longitudinal study of umbilical artery Doppler waveforms in normal pregnancy: analysis using Laplace transform techniques British Journal of Obstetrics and Gynaecology. 105(1), 78-82
  • BRACKLEY, K.J., RAMSAY, M.M., BROUGHTON PIPKIN, F. and RUBIN, P.C, 1998. A longitudinal study of maternal blood flow in normal pregnancy and the puerperium: analysis of Doppler waveforms using Laplace transform techniques British Journal of Obstetrics and Gynaecology. 105(1), 68-77
  • DUNLOP, D.C., BROUGHTON PIPKIN, F., DUNSTER, G.D., WOODHEAD, S. and O'HARE, J.P, 1998. ABSTRACT: The immediate effects of an oral calcium load and the longer-term effects of oral calcium supplementation in normal pregnancy Journal of Obstetrics and Gynaecology.. S42-S43
  • BROUGHTON PIPKIN, F, SHARIF, J and LAL, S, 1998. Predicting high blood pressure in pregnancy: a multivariate approach. Journal of Hypertension. 16(2), 221-9
  • CHAMBERLAIN, G and BROUGHTON PIPKIN, F, eds., 1998. Clinical Physiology in Obstetrics 3rd ed. Oxford: Blackwell Science.
  • EDWARDS, R. and BROUGHTON PIPKIN, F, 1998. ABSTRACT: Autoradiographic localization of angiotensin II receptors at the implantation site in the guineapig Journal of the Society for Gynecologic Investigation. 5(Suppl 1), 117A
  • MORGAN, L., CRAWSHAW, S., BAKER, P. N., EDWARDS, R., PIPKIN, F. B. and KALSHEKER, N., 1997. Functional and genetic studies of the angiotensin II type 1 receptor in pre-eclamptic and normotensive pregnant women Journal of Hypertension. 15(12), 1389-1396
  • BROUGHTON PIPKIN, F and BAKER, P N, 1997. Angiotensin II has depressor effects in pregnant and nonpregnant women. Hypertension. 30(5), 1247-52
  • BROUGHTON PIPKIN, F., CHAN, K.K. and ROBINSON, G, 1997. Differential sensitivity of human non-pregnant and pregnant myometrium to calcitonin generated peptide Journal of The Society for Gynaecological Investigation. 4, 15-21
  • MORGAN, L., PIPKIN, F. B. and KALSHEKER, N., 1996. DNA polymorphisms and linkage disequilibrium in the angiotensinogen gene Human Genetics. 98(2), 194-198
  • BING, C, JOHNSON, I R and BROUGHTON PIPKIN, F, 1996. Angiotensin receptors in myometrium and myometrial vessels from uteri of women during the follicular and luteal phases of the menstrual cycle and in late pregnancy. Clinical Science. 90(6), 499-505
  • FORHEAD, A J, WHYBREW, K, HUGHES, P, BROUGHTON PIPKIN, F, SUTHERLAND, M and FOWDEN, A L, 1996. Comparison of angiotensin II type 1 receptor blockade and angiotensin-converting enzyme inhibition in pregnant sheep during late gestation. British Journal of Pharmacology. 119(2), 393-401

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