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William Whitehouse

Clinical Associate Professor, Faculty of Medicine & Health Sciences

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Biography

As well as developing and running trials, Dr Whitehouse is active in other areas of clinical research.

Recent projects have included trials of antiepileptic treatments, migraine treatments, sleep disorders treatments, the development of associated movements in normal children, the development of a new autonomic function assessment protocol for children, the follow-up of children with acute CNS inflammation, and a brain MRI study of children with Ataxia Telangiectasia (A-T), using cutting edge techniques (CATNAP).

He is also active in clinical audit and service evaluation, frequently working on projects with medical students, e.g. in their honours year or special study modules. He developed the role of patient and public involvement, in collaboration with the Medicines for Children Research Network (MCRN) East (now the Children's Clinical Research Network), engaging patient groups and their families, and school children, in focus groups and questionnaires to inform all stages of study design.

Projects in set-up in 2016 include a PhD study of the Natural History of A-T (N-HAT) funded by Action for A-T; and a clinical trial in patients with A-T (ATTeST) sponsored by EryDel.

Dr Whitehouse is an enthusiastic collaborator and likes working in multidisciplinary teams.

Expertise Summary

Dr Whitehouse has been a consultant paediatric neurologist in major teaching centres in the United Kingdom for over 20 years. His main clinical interests include paroxysmal disorders: epilepsies, headaches, syncope, sleep disorders, and acute encephalopathies. He has been a leading member of the multidisciplinary team running the national children's Ataxia Telangiectasia (A-T) clinic in Nottingham for over 15 years.

He has considerable experience in running and contributing to clinical trials in children, clinical audit and service evaluation, and guideline development locally and nationally.

Dr Whitehouse enjoys teaching medical undergraduates and postgraduates, and coordinated the honors year for child health for several years and now leads the child health module in clinical phase 2 of the medical undergraduate course. He has supervised and co-supervised BMedSci, MSc, MD, and PhD projects, and examined MD and PhD dissertations both for the University of Nottingham and externally for the Universities of Swansea, Glasgow, University College London, Bath, and Bristol.

Teaching Summary

I have just completed my term as co-ordinator for Child Health for the Honours Year Course in Clinical Sciences (2005-2011).

I have led the development and deployment of the Developmental Neurosciences taught course (A13 DNS) for which I remain the Module Convenor (2005-).

I lead the Child Health module (A14 CHH) of the Clinical Phase 2 (2013-).

I regularly supervise and examine Honours Year student projects in Clinical Sciences (2001-).

I regularly teach and examine Paediatrics & Child Health to medical students (2001-).

I regularly teach and examine for the University of London MSc in Epileptology (2005-).

I regularly teach on the national Paediatric Epilepsy Training (PET) courses at levels 1, 2, 3, "expert to expert", and helped develop and teach on the Children's Headache Training (CHaT) course organised by the British Paediatric Neurology Association (2005-).

I regularly teach and supervise or examine MSc, MD, PhD students, and medical postgraduates for MRCPCH, and give various invited lectures.

Research Summary

PI cohort study of acute inflammatory demyelination in children (PUDDLS)

PI for a multicentre trial of cannabinoid in children wit severe spastisity (Sativex)

CI for a natural history study of Ataxia Telangiectasia (N-HAT)

PI for a multinational trial in Ataxia Telangiectasia (ATTeST)

PI Systematic prospective study of adverse events in children and young people on antiepileptic drugs.

Recent Publications

  • JACKSON T, CHOW G, SURI M, BYRD P, TAYLOR MR and WHITEHOUSE WP, 2016. Longitudinal analysis of the neurological features of Ataxia Telangiectasia Developmental Medicine & Child Neurology.
  • CROW YJ, CHASE DS, LOWENSTEIN SCHMIDT J, SZYNKIEWICZ M, FORTE GM, GORNALL HL, WHITEHOUSE WP, LIVINGSTON JH, ROZENBERG F, LEBON P, VANDERVER A, ORCESI S and RICE GI, 2015. Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1 Am J Med Genet. 167A, 296-312
  • JOSEPH D, CHONG NW, SHANKS ME, ROSATO E, TAUB MA, PETERSEN SA, SYMONDS ME, WHITEHOUSE WP and WAILOO M, 2015. Getting rhythm: how do babies do it? Archives of Disease in Childhood Fetal & Neonatal Edition. 100, 50-54
  • MANISH PRASAD, MIN TSUI ONG and WILLIAM P WHITEHOUSE, 2014. Fifteen minute consultation: tremor in children Arch Dis child Educ Pract Ed: Education & Practice Online First. 1-5

I led on Consumer Involvement for the Medicines for Children Research Network (MCRN) East (now Children's Clinical Research Network). I was a member of the MHRA's Paediatric Expert Advisory Group. I have worked on a number of evidence based guideline development groups for NICE, SIGN, and RCPCH, on headache, epilepsies, chronic fatigue/ME, and palliative care in children and young people. I am a Consultant Paediatric Neurologist at the Nottingham University Hospitals NHS Trust, with particular clinical interests in epilepsies, headache, syncope and other paroxysmal disorders. Leisure activities include horse riding, swimming, and playing drum in a ceilidh band.

Past Research

PI RCT Melatonin for children with neurodisabilities and disordered sleep (MENDS).

PI RCT Vagal Nerve Stimulation (VNS) for intractible epilepsies (E-06).

PI RCT emergency treatment of prolonged seizures in children and young people in the Emergency Department.

CI pilot RCT home administration of emergency treatment of prolonged seizures in children and young people.

PI RCT treatment of infantile spasms (UKISS, ICISS).

CI Assessment of associated movements (motor development) in children and Fog's test.

CI Development of a protocol for the assessment of autonomic function in children and young people.

Future Research

CI validation study of AT Neurological Examination Scale Toolkit (A-T NEST)

PI trial of IVIG in acute encephalopathy in children and young people (IgNITE)

PI trial of treatment regime in Dancing Eye Syndrome (UMSCOM).

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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