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Wayne Carter

Lecturer & Principal Investigator, Faculty of Medicine & Health Sciences

Contact

  • workRoom Room 3010 Division of Medical Sciences & Graduate Entry Medicine
    Royal Derby Hospital
    Uttoxeter Road
    Derby
    DE22 3DT
    UK
  • work01332 724738
  • fax01332 724626

Biography

Dr Wayne Grant Carter received his Honours degree in Biochemistry with Nutrition from the University of Southampton. He then completed a PhD at the University of Southampton studying the molecular signalling cascade elicited by insulin supervised by Dr Graham Sale. Dr Carter then moved to the Babraham Institute, Cambridge, to work with Professor Jeremy Saklatvala, on studies to elucidate the signalling mechanisms activated as a response to pro-inflammatory cytokines. Dr Carter then relocated with Professor Saklatvala's group to the Kennedy Institute of Rheumatology, part of Imperial College, London. Subsequently, Dr Carter moved to the University of California at Irvine to work with Professor Dana Aswad, similarly studying protein damage and repair. Dr Carter then joined the Department of Human Anatomy & Genetics headed by Professor Dame Kay Davies CBE FRS at the University of Oxford, before moving to take up an industrial post with Mobious Genomics, Exeter.

In 2003, Dr Carter joined the Medical Research Council Applied Neuroscience Group at the University of Nottingham headed by Professor David Ray. He has remained at the University of Nottingham where he is currently a Principal Investigator and Lecturer at the University of Nottingham Medical School site within the Royal Derby Hospital, Derby. In addition, Dr Carter has worked within the School of Sport Exercise & Health Sciences at Loughborough University, headed by Professor Myra Nimmo .

His research studies are concerned with an understanding of protein changes that can trigger pathology. In recent years this has have focused upon hepato- and neuro- toxicological mechanisms. His lab employs cell and animal models and human postmortem tissue to understand pathological changes, and utilizes a broad range of biological and biochemical techniques to study disease. Current projects include an examination of biological targets of environmental pesticides in brain, hepato- and neuro-pathology of alcohol abuse, and protein aggregation in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

Dr Carter has received external grant funding for his academic studies from research funding bodies that include the Wellcome Trust, The Physiological Society, UK Sport, and the National Institutes of Health, USA, and also from commercial sources that include Syngenta. His professional affiliations include the American College of Sports Medicine, the Biochemical Society, the British Neuroscience Association, the British Toxicological Society, the Physiological Society, and the Royal Society of Chemistry.

He has peer-reviewed manuscripts for numerous academic journals including: American Journal of Physiology; Bioanalysis, Biochemica et Biophysica Acta; Brain Research; Drug & Chemical Toxicology; Environmental Toxicology; FEBS Letters; Food & Chemical Toxicology; Genes & Nutrition; International Journal of Biomedical Science; International Journal of Environmental Research & Public Health; Journal of Chromatography B; Journal of Hazardous Materials; Journal of Inflammation Research; Journal of Membrane Science & Technology; Medicinal Chemistry Letters; Toxicological Sciences; World Journal of Biological Chemistry; World Journal of Cardiology; World Journal of Gastroenterology.

He is also a grant reviewer for the Medical Research Council and the National Centre for the Replacement, Refinement & Reduction of animals (NC3Rs).

He is currently an Editorial Board member of the BIOINFO Journal of Proteomics; Current Chemical Research; Journal of Analytical Sciences, Methods and Instrumentation; World Journal of Biological Chemistry; and Executive Editor for Europe for Journal of Chromatography and Separation Techniques; Institute of Research Engineers & Doctors (IRED): International Journal of Chemistry and International Journal of Chemistry & Pharmaceutical; Journal of Cardiology & Therapy.

Expertise Summary

Understanding the molecular mechanisms that underpin disease provides the basis for targeted therapeutics. The research in my lab is concerned with understanding protein changes and modifications that can trigger pathology. In recent years we have focussed upon hepato- and neuro- toxicological mechanisms. We employ cell and animal models and human postmortem tissue to understand pathological changes, and utilise a broad range of biological and biochemical techniques to study disease. Current projects include an examination of biological targets of environmental pesticides in brain, hepato- and neuro-pathology of alcohol abuse, and protein aggregation in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

My research expertise includes methods utilized to detect and quantify post-translational modifications, and examine tissue, cell, and protein damage and repair mechanisms;

  • 1D and 2D proteomic separation techniques; mass spectrometry; and autoradiographic imaging.
  • Immuno-detection methods. animal dosing and toxicokinetics.
  • Protein and peptide purification techniques, including FPLC and Smart system IEC, SEC, HIC, affinity-ligand, and RP-HPLC.
  • Gene cloning, recombinant protein production and purification.
  • Biophysical methods such as surface plasmon resonance.
  • Synthetic methods such as solid phase peptide and phosphopeptide synthesis.
  • Cell monolayer and suspension culturing.
  • Small animal surgery, and toxicokinetic measurements.

Teaching Summary

BSc (Hons) Medical Physiology & Therapeutics:

  • Co-module Convenor for A12 Cancer Biology, and A13 Lipid Signalling.
  • Module Contributor to A11 Infection & Defense (teaching immunology), A11 Supply & Demand I (teaching nutrition & metabolism), A11 Body Structure & Function (teaching cellular signalling), A12 Neuroscience (teaching neurodegeneration), A12 Pharmacology & Therapeutics (teaching drug use and toxicity).
  • A13 PRJ - final year research project supervisor.
  • Foundation and Qualifying year Exams Progression Adviser.

Bachelor of Medicine Bachelor of Surgery (BMBS):

  • Module Contributor to A12 Structure, Function & Defence (teaching protein structure/function & viral immunology).
  • Module Contributor to A12 Integrative (providing problem based learning (PBL) facilitation).
  • BMedSci research project supervisor.
  • Graduate Entry Medicine (GEM) interview panel member.
  • BMBS University of Nottingham Graduate Alumni administrator.

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Research Summary

Disease pathogenesis may be multifactorial, and influenced by a number of variables including age, lifestyle, genetic predisposition, and interaction with the environment. In order to understand and… read more

Current Research

Disease pathogenesis may be multifactorial, and influenced by a number of variables including age, lifestyle, genetic predisposition, and interaction with the environment. In order to understand and treat disease, there is a need to comprehend pathology at the molecular level. My research is directed toward a dissection of protein modifications and damage, and protein repair mechanisms.

In recent years we have focussed upon hepato- and neuro- toxicological mechanisms. We employ cell and animal models and human postmortem tissue to understand pathological changes, and utilise a broad range of biological and biochemical techniques to study disease. Current projects include an examination of biological targets of environmental pesticides in brain, hepato- and neuro-pathology of alcohol abuse, and protein aggregation in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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