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Nottingham Digestive Diseases Centre

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Image of Guru Aithal

Guru Aithal

Head of Division, Faculty of Medicine & Health Sciences

Contact

  • workRoom W/E 1418 E Floor, West Block
    Queen's Medical Centre
    Nottingham
    NG7 2UH
    UK
  • work0115 823 1149 (PA)
  • fax0115 970 9012

Biography

Professor Aithal has been a Consultant Hepatobiliary Physician at Nottingham University Hospitals NHS trust since 2001. He is the Lead Director of the NIHR Nottingham Digestive Diseases Biomedical Research Unit, and the Head of Division for the Nottingham Digestive Diseases Centre, University of Nottingham. He is also a Professor of Hepatology at The University of Nottingham.

Professor Aithal's interests centre around translational research in the following areas:

  • Drug-induced liver injury (causality assessment, outcome, genetic and environmental factors that effect drug metabolism and hepatotoxicity).
  • Non-alcoholic fatty liver disease (mechanisms, biomarkers, lifestyle and pharmacological interventions).
  • Epidemiology of liver and biliary disease (cause and consequences)
  • Hepatobiliary imaging (quantitative magnetic resonance imaging to evaluate chronic liver disease, novel techniques to assess the degree of liver injury and impairment of function).

His future research plans include the following:

  • Quantitative and dynamic MRI techniques in chronic liver disease
  • Dietary, life style and genetic factors associated with the non-alcoholic fatty liver disease (NAFLD)
  • Mechanisms and efficacy evaluation of interventions in NASH
  • Identification, development and validation of markers of liver injury

Expertise Summary

  • Pharmacogenetics
  • Non-alcoholic fatty liver disease (mechanisms, biomarkers of liver injury and effective lifestyle and pharmacological interventions)
  • epidemiology of liver and biliary disease (cause and consequences)
  • Hepatobiliary imaging (assessment of degree of liver injury and endoscopic imaging techniques).
  • Drug-induced liver injury ((DILI) causality assessment, outcome, genetic and environmental factors that effect drug metabolism and hepatoxicity)

Teaching Summary

Having worked in University hospitals in the United Kingdom and abroad, Guru has gained experience in a variety of teaching environments and modalities. He has been a Member of the Specialty… read more

Research Summary

Current Research

Drug-induced liver injury (DILI): Genetic and environmental factors associated with drug-induced liver injury, non-invasive markers to detect and monitor hepatotoxicity.

Non-alcoholic fatty liver disease (NAFLD): Interaction of dietary and genetic factors in the pathogenesis, non-invasive detection and stratification of NAFLD, effective interventions

Non-invasive evaluation of chronic liver disease: Application of Quantitative Magnetic Resonance Imaging methods to detect and estimate degree of liver injury in chronic liver diseases.

Hepato-pancreatico-biliary imaging: Optimising endoscopic evaluation of hepato-pancreatico-biliary neoplacia; tools and techniques

Recent Publications

Having worked in University hospitals in the United Kingdom and abroad, Guru has gained experience in a variety of teaching environments and modalities. He has been a Member of the Specialty Certificate Examination (SCE) Examining Board in Gastroenterology since inception in 2007.

Past Research

  • Drug-induced liver injury (causality assessment, outcome, genetic and environmental factors that effect drug metabolism and hepatotoxicity).
  • Non-alcoholic fatty liver disease (mechanisms and biomarkers of liver injury and effective interventions).
  • Epidemiology of liver and biliary disease (cause and consequences)
  • Endoscopic hepato-pancreatico-biliary imaging (tools and techniques)

Future Research

Quantitative and dynamic MRI techniques in chronic liver disease: In collaboration with Prof Penny Gowland and Dr Susan Francis (Sir Peter Mansfield MRI Centre), we have validated simple, non-contrast MRI methods to quantify fat, inflammation, iron and fibrosis within the liver. We will use quantitative and dynamic MRI techniques to investigate the pathophysiology of non-alcoholic fatty liver disease and portal hypertension. We will evaluate the relationship between splanchnic perfusion, bowel transit and bacterial translocation. We will use MR spectrospcopic methods to evaluate the effects of dietary and life style interventions in chronic liver diseases

Dietary, life style and genetic factors associated with the non-alcoholic fatty liver disease (NAFLD): Considering its prevalence, any intervention that is proposed in the prevention and therapy of NAFLD, essentially has to be applicable to a substantial proportion of the population. Currently, I am collaborating with Prof Macdonald, Prof Andy Salter and Dr Andrew Bennett to investigate intense dietary interventions in bariatric surgery patients. I have also established collaboration with Institute of Population Health and Science, Trevandrum and Centre for Cellular and Molecular Biology, Hyderabad, India; in a well characterized population based cohort we will investigate the interaction between dietary and environmental factors related to the development of NAFLD.

Identification, development and validation of markers of liver injury: As a co-chair of International DILI Consortium (iDILIC), I have collected a large cohort of deeply phenotyped patients with DILI for pharmacogenetics studies. We will perform large scale case-control association studies using 'whole genome genotyping/ exon sequencing' methods to identify novel genetic factors underlying DILI pathogenesis.

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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