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Nottingham Digestive Diseases Centre

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Jane Grove

Assistant Professor, Faculty of Medicine & Health Sciences

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Biography

ORCiD:0000-0002-9950-7201

I am an Assistant Professor in the Hepatology Group in the NIHR Nottingham Biomedical Research Centre and the MRC-funded Nottingham Molecular Pathology Node (http://www.nmpn.info/). My research includes translational research projects in the following areas:

  • Drug-induced liver injury (assessment, genetic and environmental factors that affect drug metabolism and hepatotoxicity).
  • Non-alcoholic fatty liver disease and alcoholic liver disease (mechanisms and biomarkers of liver injury).
  • Genetic determinants of liver disease.
  • Development and validation of markers of oxidative stress in the evaluation of acute liver injury and chronic liver diseases.
  • Non-invasive assessment of liver fibrosis.
  • Clinical application of liver biomarkers.
  • Experimental diagnostics of chronic liver injury.

I am Divisional Safety Officer and Human Tissue Authority Person Designate for the Nottingham Digestive Diseases Centre.

I am a member of the UK Stratified Medicine and Pharmacogenetics Committee and am involved in developing Biobank networks.

Research Experience:

Analysis of genetic determinants of the development of alcoholic liver disease. (Newcastle University)

Improvement of E. coli nitroreductase by mutagenesis: a route to optimization of virus- directed enzyme-prodrug cancer therapy. (Cobra Therapeutics)

DNA double-strand break repair in E. coli. (Nottingham University)

Role of novel Type IV secretion systems in Helicobacter pylori virulence. (Nottingham University)

Degree: Molecular Biology and Biochemistry (Durham University)

PhD: Escherichia coli genes essential for formate-dependent nitrite reduction, cytochrome c biosynthesis and periplasmic nitrate reduction. (Birmingham University)

Expertise Summary

Quantification of circulating biomarkers including Luminex multiplex analysis on Bioplex 200

Characterisation and phenotyping of patient cohorts and analysis of clinical data

Expression analyses including assessment of liver tissue markers

Molecular genetics including detection of polymorphisms, cloning, PCR and sequencing

Biochemistry (including protein expression, purification and analysis)

Biobanking: setting up a Research Tissue Bank, clinical sample collection, storage and cataloging/databases

Microbiology: specialist in E.coli and H.pylori manipulation and phenotyping

Research Summary

I am a postdoctoral research scientist in the Hepatology Group in the NIHR Nottingham Digestive Diseases Biomedical Research Unit and Nottingham Molecular Pathology Node. I am involved in… read more

Selected Publications

Current Research

I am a postdoctoral research scientist in the Hepatology Group in the NIHR Nottingham Digestive Diseases Biomedical Research Unit and Nottingham Molecular Pathology Node. I am involved in translational research in the following areas: Drug-induced liver injury (assessment, genetic and environmental factors that affect drug metabolism and hepatotoxicity). Non-alcoholic fatty liver disease (mechanisms and biomarkers of liver injury). Hepatobiliary imaging (assessment of degree of liver injury). Development and validation of markers of oxidative stress in the evaluation of acute liver injury and chronic liver diseases. Non-invasive assessment of liver fibrosis. Experimental diagnostics of chronic liver injury. Clinical application of liver biomarkers.

Current projects:

Identification of serum biomarkers of non-alcoholic fatty liver disease (NAFLD)

Investigation of the role of genetic polymorphisms in contributing to NAFLD development and progression.

Association of HLA types with drug-induced liver injury and assessment of injury phenotypes.

Investigation of serum biomarkers in alcoholic liver disease.

I am the coordinator of a European Biorepository for drug-induced liver injury (Pro-Euro DILI).

I also completed a NUH pump-priming award to investigate telomerase activity as a measure of cumulative burden of oxidative stress in non-alcoholic fatty liver disease.

Past Research

Role of novel Type IV secretion systems in Helicobacter pylori virulence. (PI Rob Delahay)

DNA double-strand break repair in E. coli. (PI Bob Lloyd)

Future Research

The Nottingham Molecular Pathology Node for Integrated Multi-platform Biomarker Research and Knowledge Transfer -bringing together informatics, computational modelling and molecular pathology to find new biomarkers for a range of diseases, particularly those affecting the digestive and respiratory systems and the liver.

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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