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Nottingham Digestive Diseases Centre

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Rob Delahay

Assistant Professor, Faculty of Medicine & Health Sciences

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Research Summary

Numerous bacterial pathogens employ specialized secretion systems to interact with and modify the host cellular environment. Our research is focused on the functional characterisation of two such… read more

Recent Publications

Current Research

Numerous bacterial pathogens employ specialized secretion systems to interact with and modify the host cellular environment. Our research is focused on the functional characterisation of two such secretion systems; the type III secretion system (T3SS) of the pediatric diarrheal pathogen enteropathogenic Escherichia coli (EPEC), and two functionally disparate type IV secretion systems (T4SS) of the gastric pathogen Helicobacter pylori. Working within the Centre for Biomolecular Sciences (CBS) building (http://www.nottingham.ac.uk/cbs/index.aspx), we use an extensive array of molecular and protein biochemical techniques, together with in vitro models of infection, epifluorescence microscopy and comprehensive bioinformatics analyses. Our main projects aim to dissect key stages in the host-pathogen interaction by characterisation of major bacterial virulence determinants which promote successful host colonisation and predispose towards disease.

Projects presently include:

  • Characterisation of protein components of the surface filament structure of the cag pathogenicity island encoded-T4SS of H. pylori
  • Functional characterisation of a novel T4SS associated with the most severe disease outcomes of H. pylori infection (gastric cancer and duodenal ulcer)
  • Development of novel protein transfection technology for the study of bacterial effector protein function.

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Grant funding

  • MRC
  • University of Nottingham.

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Group members

  • Dr Jane Grove
  • Nicola Croxall
  • Amin Jalili
  • Maher Alandiyjany
  • Amberley Stephens.

Informal enquiries from overseas students regarding self-funded postgraduate (PhD) study within the group are welcome at any time.

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

Contacts: Please see our 'contact us' page for further details