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Nottingham Digestive Diseases Centre

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Robin Spiller

Professor of Gastroenterology, Faculty of Medicine & Health Sciences

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Biography

Educated at Cambridge University and University College Hospital London

SHO posts at Hammersmith, London Chest and Queens Square and West Middlesex. 1975-78 Registrar at Charing Cross,West and Central Middlesex 1978-1984.

MRC Travelling Fellowship to Mayo Clinic 1984-5

Senior Registrar Central Middlesex 1985-1988 Appointed Consultant Physician University Hospital Nottingham

!998 Reader and Honorary Consultant Physician University of Nottingham

2000 onwards Professor of Gastroenterology

2010 -2014 Lead Director of the Nottingham Digestive Diseases Centre Biomedical Research Unit

2010 Elected Senior NIHR Investigator

Editor of Gut an international journal of Gastroenterology and Hepatology from 2003 -2009.

Expertise Summary

My main interest is in the pathophysiology of functional GI diseases, particularly focusing on the role of infection and inflammation and alterations in serotonin metabolism in the irritable bowel syndrome. I have twice edited the British Society of Gastroenterology ( BSG )Guidelines for the management of IBS and am a member of the Board of the Rome Foundation, an international group which produced the Rome III criteria for the classification of the functional GI diseases.

I was the founding Chairman of the Neurogastroenterology and Motility Section of the British Society of Gastroenterology (BSG)

I was a member of MRC EME Board 2010-2014 and National Institute for Health Research Senior Investigator. I am the author/co-author of more than 335 scientific reviews and original publications.

Research Summary

Busy GI practice with special interest in functional GI diseases, motility disorders.Research interests include pathology of post-infectious irritable bowel syndrome, neuropathology following gut… read more

Selected Publications

Current Research

Busy GI practice with special interest in functional GI diseases, motility disorders.Research interests include pathology of post-infectious irritable bowel syndrome, neuropathology following gut inflammation .I also have an interest in the application of MRI to study GI pathophysiology

Techniques

  • Inflammation and irritable bowel syndrome and genetic basis of IBS
  • Clinical trials and functional bowel disease projects
  • Intestinal motility assessment using MRI
  • Functional brain imaging (fMRI) and assessments of visceral hypersensitivity
  • Assessments of visceral hypersensitivity

Projects

  • Inflammation in irritable bowel syndrome
  • Genetic basis of Irritable Bowel Syndrome
  • Abnormalities of serotonin metabolism in GI disease
  • Effects of inflammation on mucosal nerves and sensitivity
  • Functional magnetic resonance imaging of brain responses to oral fat
  • Effect of novel food substances on gastric motility
  • Effects of infection on visceral hypersensitivity

Past Research

Pathophysiology of functional GI diseases

Original description of postinfectious irritable bowel syndrome, particularly focusing on the role of inflammation and alterations in serotonin metabolism in the irritable bowel syndrome.

Development of MRI for studying gastric processing of complex meals

Future Research

Pathology of post-infectious Irritable bowel syndrome Functional brain imaging to explore pain pathways Neuropathology of post-inflammatory bowel disease Role of physical form of food in altering gastric and intestinal function, satiety. MRI assessment of colonic function and changes in gut microbiota following an infection and associated with clostridium difficile infection.

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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