Molecular genetics, Immunohistochemistry, Microarrays and data analysis.
I have recently started a new role researching the pathogeneisis of Lymphangioleiomyomatosis (LAM) in Professor Simon Johnson's group. This is supported by the NIHR Rare Diseases Translational… read more
SOLER ARTIGAS M, WAIN LV, MILLER S, KHEIRALLAH AK, HUFFMAN JE, NTALLA I, SHRINE N, OBEIDAT M, TROCHET H, MCARDLE WL, ALVES AC, HUI J, ZHAO JH, JOSHI PK, TEUMER A, ALBRECHT E, IMBODEN M, RAWAL R, LOPEZ LM, MARTEN J, ENROTH S, SURAKKA I, POLASEK O, LYYTIKÄINEN LP, GRANELL R, HYSI PG, FLEXEDER C, MAHAJAN A, BEILBY J, BOSSÉ Y, BRANDSMA CA, CAMPBELL H, GIEGER C, GLÄSER S, GONZÁLEZ JR, GRALLERT H, HAMMOND CJ, HARRIS SE, HARTIKAINEN AL, HELIÖVAARA M, HENDERSON J, HOCKING L, HORIKOSHI M, HUTRI-KÄHÖNEN N, INGELSSON E, JOHANSSON Å, KEMP JP, KOLCIC I, KUMAR A, LIND L, MELÉN E, MUSK AW, NAVARRO P, NICKLE DC, PADMANABHAN S, RAITAKARI OT, RIED JS, RIPATTI S, SCHULZ H, SCOTT RA, SIN DD, STARR JM, , VIÑUELA A, VÖLZKE H, WILD SH, WRIGHT AF, ZEMUNIK T, JARVIS DL, SPECTOR TD, EVANS DM, LEHTIMÄKI T, VITART V, KÄHÖNEN M, GYLLENSTEN U, RUDAN I, DEARY IJ, KARRASCH S, PROBST-HENSCH NM, HEINRICH J, STUBBE B, WILSON JF, WAREHAM NJ, JAMES AL, MORRIS AP, JARVELIN MR, HAYWARD C, SAYERS I, STRACHAN DP, HALL IP and TOBIN MD, 2015. Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature communications. 6, 8658
MILLER, S., PROBERT, K., KHEIRALLAH A.K. and HALL, I. P., 2015. Developmental genetics of the COPD lung COPD Research and Practice. 1(10),
I have recently started a new role researching the pathogeneisis of Lymphangioleiomyomatosis (LAM) in Professor Simon Johnson's group. This is supported by the NIHR Rare Diseases Translational Research Collaboration.
LAM is a rare lung and lymphatic disease which leads to cystic lesions in the lungs. LAM affects women and is caused by a defect in one of the two proteins associated with Tuberous Sclerosis, Tuberin and Hamartin. Utilising data collected from the current study we want to identify diagnostic and prognostic biomarkers in LAM and better understand why some women with LAM have stable disease for many years whilst others progress in a relatively short period of time.
Molecular and genetic mechanisms underlying Chronic Obstructive Pulmonary Disease (COPD), specifically the involvement of Advanced Glycosylation End Product-Specific Receptor (RAGE, 6p21).
COPD is a chronic disorder of the lungs which causes airway obstruction. This disease is a major cause of morbidity and mortality worldwide. It is estimated that 3 million people in the UK have COPD, which causes 30,000 deaths in the UK each year. Genome-wide association studies have shown an association with RAGE and lung function (Repapi et al., 2010. Nature Genetics 42, 36-44). By characterising the membrane and soluble forms of RAGE, we hope to idenitify RAGE's involvement in COPD in the hope of developing novel therapies for this debilitating and progressive disease.