School of Medicine
  • Print
   
   

School staff listing

People listings by divisions

 

Image of Alan Knox

Alan Knox

Professor of Respiratory Medicine, Faculty of Medicine & Health Sciences

Contact

Biography

I am Professor of Respiratory Medicine at Nottingham University based on the City Hospital Campus and Director of the Nottingham Respiratory Biomedical Research Unit, Nottingham MRC Molecular Pathology Node and the Respiratory theme in the NIHR Nottingham Biomedical Research Centre. I am currently on the editorial advisory boards of Thorax and AJP (Lung), having previously been executive editor of Thorax and on the editorial board of Clinical Science. My main research interests are in the molecular pathophysiology of lung diseases (asthma, COPD, pulmonary hypertension, idiopathic pulmonary fibrosis, cystic fibrosis) and translational research in these areas. I have published over 190 articles in scientific journals. I have previously served or am currently serving on a number of committees including the Wellcome Trust Physiological Sciences funding Committee, BLF Grants Committee, MRC Panel of experts, MRC Medical Advisory Board, Asthma UK grants committee, BTS Scientific Programme Committee, BTS Research Committee.

Expertise Summary

Structural cell (airway smooth muscle, fibroblast, epithelial cell) function in asthma, COPD, and IPF, particularly with regard to remodelling and synthetic functions. Mechanisms of transcriptional regulation particularly epigenetic control, protein kinase C isoforms, PPARs, angiogenic factors, chemokines, lipid mediators, human cell models of lung disease. Translational studies of asthma, COPD and cystic fibrosis particularly development of epigenetic modifiers in asthma and COPD, quorum sensing molecules as a biomarker and therapeutic target in CF, biomarkers in COPD.

Research Summary

My main research interests are in the molecular pathophysiology of lung diseases (asthma, COPD, pulmonary hypertension, idiopathic pulmonary fibrosis, cystic fibrosis) and translational research in… read more

Selected Publications

Current Research

My main research interests are in the molecular pathophysiology of lung diseases (asthma, COPD, pulmonary hypertension, idiopathic pulmonary fibrosis, cystic fibrosis) and translational research in these areas. Translational research themes include drug discovery, experimental medicine and biomarker research. Our work is funded by a number of sources including MRC, BBSRC, Wellcome Trust, Lung charities and industry. The work is closely integrated with work in the Respiratory Biomedical Research Unit.

CURRENT GRANTS

1. NIHR Nottingham Biomedical Research Centre £24M 2017-2022 Respiratory Theme PI (£4.5M)

2. Nottingham MRC Molecular Pathology Node 2015-2019 £4.5M Director of Node

3. Wellcome Trust Doctoral Training Programme in Antimicrobials and Antimicrobial Resistance 2016-2020 (joint Nottingham/Birmingham). ​£5M

4. MRC Nottingham CIC Award 2016-2018 £850K

5. MRC MR/K003259/1 Myofibroblast differentiation in idiopathic pulmonary fibrosis: epigenetic mechanisms and therapeutic targeting by cAMP £561K 2012-2017.

6. MRF/Asthma UK 2015-298 Airway smooth muscle DNA methylation: a novel target for asthma therapy 2016-2019 £300K

7. Asthma UK AUK-PHD-2013-234 Exploring Histone Arginine Methylation as a therapeutic target in asthma: regulation of CXCL-8 secretion 2014-2018 £90K

8. Henry Smith Charity. 2016-2017 DNA methylation in asthma £49K.

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

Contacts: Please see our 'contact us' page for further details