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Ana Valdes

Associate Professor and Reader, Faculty of Medicine & Health Sciences


  • workRoom A25, Academic Rheumatology Clinical Sciences Building
    Nottingham City Hospital
    Hucknall Road
    NG5 1PB
  • work0115 823 1954
  • fax0115 823 1757


Ana M. Valdes received her M.A. and Ph.D. from the University of California at Berkeley, USA, where she specialized in Genetic Epidemiology. She is a reader and associated professor at the University of Nottingham. Her research is focused on deciphering the molecular mechanisms related to ageing and in particular age related diseases such as osteoarthritis

Research Summary

My current research interests encompass three separate fields:

  1. Genetics and molecular basis of osteoarthritis (OA): I have established extensive collaborations in this field with groups throughout Europe, Australia and the US, putting together one of the largest collections of DNA samples to study the genetics of this disease. I carried out the first GWAS on knee OA, am part of several OA GWAS consortia, and have co-authored over 44 peer reviewed articles in this field. I am the scientific lead for the TREAT-OA EU consortium ( and have recently been awarded funding to study the genetic basis of pain in OA by the European League Against Rheumatism.
  1. Genetics of Type 1 Diabetes (T1D). I have collaborated for a number of years with US groups in the unraveling of the genetic and in particular, the major histocompatibility component of susceptibility to T1D, resulting in over 30 publications. I am currently a co-investigator of an NIH grant to investigate the role of HLA in T1D in ethnic minorities in the US
  1. Molecular basis of aging. I have co-authored 18 papers in this area including my work on the role of mitochondrial heteroplasmy on ageing and of telomeres as markers of biological aging as well as being a coapplicant in a Wellcome Trust programme grant to study the genetic basis of aging in female twins. I am also the principal investigator of a translational award from the Guy's and St Thomas' Trust Charity to assess the role of somatic mitochondrial mutations on atherosclerosis and obesity. The focus of my research on ageing is now moving into epigenetics, and we have been awareded an EU grant - EurHEALTHAgeing -- to study the role of epigenetic and metabolomic changes on early developmental factors (i.e. birthweight) on health outcomes related to ageing.

Selected Publications

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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