Clinical Associate Professor, Faculty of Medicine & Health Sciences
I went to medical school in Italy, where I also trained as a clinical neurologist in Florence.
I obtained my PhD in neuroscience in Florence and trained as a postdoctoral fellow at the National Institutes of Health and at the University of Pennsylvania in the USA. I was then Assistant Professor of Neurology at Thomas Jefferson University in Philadelphia, before moving to the University of Nottingham as Clinical Associate Professor.
My current research focuses on the role of viral and bacterial infections in the susceptibility to MS and on disease activity and progression, with particular interest in the cellular and molecular mechanisms underlying these effects.
The expertise of our research group is in the immunology of the nervous system, with a special focus on neuroimmunology of MS. We use cellular and molecular immunology techniques, tissue culture, molecular biology, experimental models, and clinical studies to address scientific questions in MS, with an emphasis on the mechanisms of nervous tissue damage and repair by cells of the immune system.
An overview of some key areas of our research in neuroimmunology can be found in review articles, including:
- Podda et al, 2013. Innate Immune Responses in the CNS: Role of Toll-Like Receptors, Mechanisms, and Therapeutic Opportunities in Multiple Sclerosis. J Neuroimmune Pharmacol (in press - PMID: 23812895)
- O'Brien et al. 2010. T-cell based immunotherapy in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunotherapy 2:99-115
- Nyirenda et al., 2009. Modulation of regulatory T cells in health and disease: role of toll-like receptors. Inflammation & Allergy Drug Targets 8, 124-9
As a clinician, I am Honorary consultant neurologist at Nottingham University Hospitals (NUH) and run general neurology and multiple sclerosis clinics. I am lead clinician for Neurology morbidity and mortality and member of the Medicines Management Committee of NUH. I am involved in numerous MS clinical trials as either principal investigator or co-investigator.
Multiple sclerosis, diseases of the spinal cord, neuroimmunology, general neurology.
See also: https://www.nuh.nhs.uk/our-services/services/neurology/dr-bruno-gran/
We study the interaction of the innate and adaptive immune system in multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS). Current research in our laboratory focuses on… read more
We study the interaction of the innate and adaptive immune system in multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS). Current research in our laboratory focuses on how Toll-like receptors (TLRs) modulate the function of human regulatory T cells (Tregs). Such cells inhibit the function of effector T cells, which are involved in initiating and maintaining inflammatory responses that cause damage to the central nervous system in MS. We have found that certain TLRs can reduce the function of Tregs, thus facilitating increased inflammatory activity in MS.
Another line of research focuses on how endosomal TLRs regulate the function of dendritic cells and B cells by interacting with the indoleamine 2,3-dioxigenase system in experimental models of MS.
Our larger research theme is on how infections influence people's susceptibility to develop MS, how they can reactivate disease in clinical relapses, and influence the development of disability (progression).
Previous (and ongoing) research focused on the recognition of myelin antigens by human T cell receptors and on the role of heterodimeric cytokines (IL-12, IL-23, and IL-27) in the pathogenesis of autoimmune inflammatory demyelination.
We are interested in research collaborations that can facilitate the application of basic neuroimmunology work to the treatment of patients with MS.
The Clinical Trial section of our website contains more details on completed and current trials involving patients with MS.