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Bruno Gran

Clinical Associate Professor, Faculty of Medicine & Health Sciences


  • workRoom C Floor, South Block (Room 2710) Nottingham University Hospitals, QMC
    Queen's Medical Centre
    NG7 2UH
  • work0115 823 1442
  • fax0115 970 9738


I went to medical school in Italy, where I also trained as a clinical neurologist in Florence.

I obtained my PhD in neuroscience in Florence and trained as a postdoctoral fellow at the National Institutes of Health and at the University of Pennsylvania in the USA. I was then Assistant Professor of Neurology at Thomas Jefferson University in Philadelphia, before moving to the University of Nottingham as Clinical Associate Professor.

My current research focuses on the role of viral and bacterial infections in the susceptibility to MS and on disease activity and progression, with a particular interest in the cellular and molecular mechanisms underlying these effects.

Expertise Summary

The expertise of our research group is in the immunology of the nervous system, with a special focus on neuroimmunology of MS. We use cellular and molecular immunology techniques, tissue culture, molecular biology, experimental models, and clinical studies to address scientific questions in MS, with an emphasis on the mechanisms of nervous tissue damage and repair by cells of the immune system.

An overview of some key areas of our research in neuroimmunology can be found in the following publications:

  • Podda et al, 2013. Innate Immune Responses in the CNS: Role of Toll-Like Receptors, Mechanisms, and Therapeutic Opportunities in Multiple Sclerosis. J Neuroimmune Pharmacol 8:791-806.
  • Nyirenda M, Crooks J, and Gran B, 2013. The Role of Toll-Like Receptors in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. In: Multiple sclerosis immunology - a foundation for current and future treatments. T. Yamamura and B. Gran, Eds. Springer, New York, (; Chapter 8, pp. 149-176.

  • Constantinescu and Gran, 2014. The essential role of T cells in multiple sclerosis: A reappraisal. Biomed J 37:34-40.

As a clinician, I am Honorary consultant neurologist at Nottingham University Hospitals (NUH) NHS Trust, where I am also the clinical lead for governance at the department of neurology. I run general neurology and MS clinics and I am the principal investigator or co-investigator in numerous clinical trials for MS.

Teaching Summary

I am the clinical academic lead for skills assessment for the University of Nottingham at Lincoln County Hospitals and the other Lincolnshire teaching sites.

I teach multiple sclerosis, diseases of the spinal cord, neuroimmunology, and general neurology - typically to medical students, junior doctors, neurology registrars, and MSc / PhD students in the fields of neuroscience and immunology.

See also:

Research Summary

We study the interaction of the innate and adaptive immune system in multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS). Current research in our laboratory focuses on… read more

Selected Publications

Current Research

We study the interaction of the innate and adaptive immune system in multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS). Current research in our laboratory focuses on how Toll-like receptors (TLRs) modulate the function of human regulatory T cells (Tregs). Such cells inhibit the function of effector T cells, which are involved in initiating and maintaining inflammatory responses that cause damage to the CNS in MS. We have found that certain TLRs can reduce the function of Tregs, thus facilitating increased inflammatory activity in MS.

Another line of research focuses on how endosomal TLRs regulate the function of dendritic cells and B cells by interacting with the indoleamine 2,3-dioxigenase system in experimental models of MS.

Our larger research theme is how infections influence people's susceptibility to developing MS, how they can reactivate disease in clinical relapses, and influence the development of irreversible disability (progression).

Past Research

Previous (and ongoing) research focused on the recognition of myelin antigens by human T cell receptors and on the role of heterodimeric cytokines (IL-12, IL-23, and IL-27) in the pathogenesis of autoimmune inflammatory demyelination.

Future Research

We are interested in research collaborations that can facilitate the application of basic neuroimmunology work to the treatment of patients with MS.

The Clinical Trial section of our website contains more details on completed and current trials involving patients with MS.

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

Contacts: Please see our 'contact us' page for further details