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Research Fellow, Faculty of Medicine & Health Sciences
I have over 10 years experience in the field of cell signalling, with technical expertise in a variety of biochemical and pharmacological techniques including radioligand binding, western blotting and second messenger signalling assays. I also have extensive microscopy experience, including confocal, FRET and epifluorescence (e.g. Ca2+ signalling) microscopy. I have worked with a variety of primary and secondary cell culture systems and have experience of basic molecular biology techniques.
My research background is in the field of G protein-coupled receptor pharmacology and in particular the signalling pathways that are activated downstream of receptor stimulation. I have particular expertise in the adenylate cyclase/cyclic AMP/protein kinase A signalling pathway and have also worked extensively on the phospholipase C/Ca2+/protein kinase C signalling cascades. I have worked on these and other signalling pathways in a number of primary cell systems, including hippocampal neurons and vascular smooth muscle cells.
I am currently working with Prof Ian Hall and Dr Ian Sayers on a project investigating the functional role in lung of genes identified in genome-wide association studies (GWAS) as being associated… read more
I am currently working with Prof Ian Hall and Dr Ian Sayers on a project investigating the functional role in lung of genes identified in genome-wide association studies (GWAS) as being associated with lung function. We are following up a number of genes previously identified by our group in GWAS meta-analysis as being associated with key indicators of lung function (FEV1 and FEV1/FVC). The overall aim is to establish whether functional variants in these genes are determinants of lung function in the general population and in patients suffering with Chronic Obstructive Pulmonary Disease (COPD).
University of NottinghamMedical School
Nottingham, NG7 2UH
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