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Beate Kehrel

Honorary Professor, Faculty of Medicine & Health Sciences

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Expertise Summary

I am an entrepreneurial scientist with special training in cell biology and medicine and lead a dedicated clinical and translational research group that works on the contribution of blood platelets to health and diseases. My interdisciplinary team, which includes biochemists, biologists specialized in cell biology, chemists, veterinarians, pharmacists, medical students, students in molecular biomedicine or biotechnology and clinicians, are especially interested in the role of platelets in thrombosis, all phases ( early to late) of arteriosclerosis, haemostasis and infection. We do our best not to work in an ivory tower, but to interact tightly with patients, clinicians and industry, to contribute one the one hand to deeper understanding of the research area and on the other hand to translate the findings into new diagnostic tools and identification of new therapeutic targets.

Research Summary

My main interest is in cellular and molecular studies of the contribution of blood platelets to haemostasis, thrombosis, arteriosclerosis and body defence.

Current projects include: • Role of protein disulfide isomerase in platelet adhesion, aggregation and procoagulant activity • Role of cell surface chaperones in platelet function • The platelet, an innate immune defence cell. Association between platelets and microorganisms. Platelet microbicidal proteins and microorganism immobilising nets. • Platelets in tumor metastasis • Posttranslational protein modifications and their role in platelet function • Regulation of alpha IIb beta III (Gp IIb/IIIa) integrin activity • Markers, which can identify that an individual is at a high cardiovascular risk • Additional modes of action of currently used anti platelet drugs • Platelet, leukocyte and endothelium endoplasmic reticulum stress in cardiovascular disease and sepsis

Recent Publications

  • HORN M, BERTLING A, BRODDE MF, MÜLLER A, ROTH J, VAN AKEN H, JURK K, HEILMANN C, PETERS G and KEHREL BE, 2012. Human neutrophil alpha-defensins induce formation of fibrinogen and thrombospondin-1 amyloid-like structures and activate platelets via glycoprotein IIb/IIIa. Journal of thrombosis and haemostasis : JTH. 10(4), 647-61
  • BERTLING A, NIEMANN S, HUSSAIN M, HOLBROOK L, STANLEY RG, BRODDE MF, POHL S, SCHIFFERDECKER T, ROTH J, JURK K, MÜLLER A, LAHAV J, PETERS G, HEILMANN C, GIBBINS JM and KEHREL BE, 2012. Staphylococcal extracellular adherence protein induces platelet activation by stimulation of thiol isomerases. Arteriosclerosis, thrombosis, and vascular biology. 32(8), 1979-90
  • JURK K, LAHAV J, VAN AKEN H, BRODDE MF, NOFER J and KEHREL BE, 2011. Extracellular protein disulfide isomerase regulates feedback activation of platelet thrombin generation via modulation of coagulation factor binding. Journal of thrombosis and haemostasis : JTH. 9(11), 2278-90
  • BRODDE MF, KORPORAAL SJA, HERMINGHAUS G, FOBKER M, VAN BERKEL TJC, TIETGE UJF, ROBENEK H, VAN ECK M, KEHREL BE and NOFER J, 2011. Native high-density lipoproteins inhibit platelet activation via scavenger receptor BI: role of negatively charged phospholipids. Atherosclerosis. 215(2), 374-82
  • KEHREL B, 2011. [Hemostasis management based on ROTEM(®): contra]. Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS. 46(5), 318-22
  • GUNAY-AYGUN M, FALIK-ZACCAI TC, VILBOUX T, ZIVONY-ELBOUM Y, GUMRUK F, CETIN M, KHAYAT M, BOERKOEL CF, KFIR N, HUANG Y, MAYNARD D, DORWARD H, BERGER K, KLETA R, ANIKSTER Y, ARAT M, FREIBERG AS, KEHREL BE, JURK K, CRUZ P, MULLIKIN JC, WHITE JG, HUIZING M and GAHL WA, 2011. NBEAL2 is mutated in gray platelet syndrome and is required for biogenesis of platelet α-granules. Nature genetics. 43(8), 732-4
  • BRODDE, MARTIN F and KEHREL, BEATE E, 2010. Markers of Blood Cell Activation and Complement Activation in Factor VIII and von Willebrand Factor Concentrates. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie. 37(4), 175-184
  • JURK, KERSTIN, SCHULZ, ANSGAR S, KEHREL, BEATE E, RÄPPLE, DANIEL, SCHULZE, HARALD, MÖBEST, DIETER, FRIEDRICH, WILHELM W, OMRAN, HEYMUT, DEAK, ERIKA, HENSCHLER, REINHARD and SCHEELE, JÜRGEN, 2010. Novel integrin-dependent platelet malfunction in siblings with leukocyte adhesion deficiency-III (LAD-III) caused by a point mutation in FERMT3. Thrombosis and haemostasis. 103(5), 1053-64
  • BERTLING, ANNE, NIEMANN, SILKE, UEKÖTTER, ANDREAS, FEGELER, WOLFGANG, LASS-FLÖRL, CORNELIA, VON EIFF, CHRISTOF and KEHREL, BEATE E, 2010. Candida albicans and its metabolite gliotoxin inhibit platelet function via interaction with thiols. Thrombosis and haemostasis. 104(2), 270-8
  • JURK, KERSTIN, RITTER, MARTIN A, SCHRIEK, CARSTEN, VAN AKEN, HUGO, DROSTE, DIRK W, RINGELSTEIN, E BERND and KEHREL, BEATE E, 2010. Activated monocytes capture platelets for heterotypic association in patients with severe carotid artery stenosis. Thrombosis and haemostasis. 103(6), 1193-202
  • JURK, K and KEHREL, B E, 2010. [Pathophysiology and biochemistry of platelets] Der Internist. 51(9), 1086, 1088-92, 1094
  • ESCH, JAN SCHULTE AM, JURK, KERSTIN, KNOEFEL, WOLFRAM T, ROEDER, GESINE, VOSS, HOLGER, TUSTAS, ROY Y, SCHMELZLE, M, KRIEG, ANDREAS, EISENBERGER, CLAUS F, TOPP, STEFAN, ROGIERS, XAVIER, FISCHER, LUTZ and , 2010. Platelet activation and increased tissue factor expression on monocytes in reperfusion injury following orthotopic liver transplantation. Platelets. 21(5), 348-59
  • NOFER, JERZY-ROCH, BRODDE, MARTIN F and KEHREL, BEATE E, 2010. High-density lipoproteins, platelets and the pathogenesis of atherosclerosis. Clinical and experimental pharmacology & physiology. 37(7), 726-35
  • GUNAY-AYGUN M, ZIVONY-ELBOUM Y, GUMRUK F, GEIGER D, CETIN M, KHAYAT M, KLETA R, KFIR N, ANIKSTER Y, CHEZAR J, ARCOS-BURGOS M, SHALATA A, STANESCU H, MANASTER J, ARAT M, EDWARDS H, FREIBERG AS, HART PS, RINEY LC, PATZEL K, TANPAIBOON P, MARKELLO T, HUIZING M, MARIC I, HORNE M, KEHREL BE, JURK K, HANSEN NF, CHERUKURI PF, JONES M, CRUZ P, MULLIKIN JC, NURDEN A, WHITE JG, GAHL WA and FALIK-ZACCAI T, 2010. Gray platelet syndrome: natural history of a large patient cohort and locus assignment to chromosome 3p. Blood. 116(23), 4990-5001
  • NIEMANN, SILKE, KEHREL, BEATE E, HEILMANN, CHRISTINE, RENNEMEIER, CLAUDIA, PETERS, GEORG and HAMMERSCHMIDT, SVEN, 2009. Pneumococcal association to platelets is mediated by soluble fibrin and supported by thrombospondin-1. Thrombosis and haemostasis. 102(4), 735-42
  • RITTER, MARTIN A, JURK, KERSTIN, SCHRIEK, CARSTEN, NABAVI, DARIUS G, DROSTE, DIRK W, KEHREL, BEATE E and BERND RINGELSTEIN, E, 2009. Microembolic signals on transcranial Doppler ultrasound are correlated with platelet activation markers, but not with platelet-leukocyte associates: a study in patients with acute stroke and in patients with asymptomatic carotid stenosis. Neurological research. 31(1), 11-6
  • THALER, MARKUS, BUHL, ALEXANDER, WELTER, HARALD, SCHREIEGG, ANITA, KEHREL, MARCUS, ALBER, BETTINA, METZGER, JOCHEN and LUPPA, PETER B, 2009. Biosensor analyses of serum autoantibodies: application to antiphospholipid syndrome and systemic lupus erythematosus. Analytical and bioanalytical chemistry. 393(5), 1417-29
  • PERKHOFER, SUSANNE, KAINZNER, BARBARA, KEHREL, BEATE E, DIERICH, MANFRED P, NUSSBAUMER, WALTER and LASS-FLÖRL, CORNELIA, 2009. Potential antifungal effects of human platelets against zygomycetes in vitro. The Journal of infectious diseases. 200(7), 1176-9
  • SCHROEDER, KATRIN, JULARIC, MARIO, HORSBURGH, SAMANTHA M, HIRSCHHAUSEN, NINA, NEUMANN, CLAUDIA, BERTLING, ANNE, SCHULTE, ANJA, FOSTER, SIMON, KEHREL, BEATE E, PETERS, GEORG and HEILMANN, CHRISTINE, 2009. Molecular characterization of a novel Staphylococcus aureus surface protein (SasC) involved in cell aggregation and biofilm accumulation. PloS one. 4(10), e7567
  • KEHREL, B E, 2008. [Platelets: biochemistry and physiology] Hämostaseologie. 28(5), 289-98

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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