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Linhua Pang

Professor of Molecular Medicine, Faculty of Medicine & Health Sciences

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Expertise Summary

Synthetic functions of airway structural cells (airway smooth muscle cells, fibroblasts, epithelial cells), particularly the expression and production of inflammatory cytokines, chemokines, growth factors, angiogenic factors, inflammatory enzymes and lipid mediators, and their role in the pathophysiology of asthma, idiopathic pulmonary fibrosis, COPD and cyctic fibrosis.

  • Molecular mechanisms of transcriptional regulation of key genes in human airway structural cells, particularly epigenetic mechanisms, including transcription factor activation and promoter binding, histone modifications, promoter DNA methylation, epigenetic modifying enzyme activation and recruitment, and interactions between different epigenetic pathways.
  • Molecular mechanism of action of drugs that target key gene expression and their therapeutic potential in in vitro cell model of respiratory diseases, providing the basis for further translational studies.

Teaching Summary

Airway inflammation and remodelling in chronic respiratory diseases.

Anti-inflammatory drug effect and molecular mechanisms.

Gene expression and regulation in respiratory structural cells.

Research Summary

I am a Professor of Molecular Medicine at the University of Nottingham based at Nottingham City Hospital. My main research interests are the role of airway structural cells in airway inflammation,… read more

Selected Publications

Current Research

I am a Professor of Molecular Medicine at the University of Nottingham based at Nottingham City Hospital. My main research interests are the role of airway structural cells in airway inflammation, repair, and structural remodelling in the context of chronic airway diseases such as asthma, idiopathic pulmonary fibrosis, COPD and cyctic fibrosis. I am particularly interested in the expression and molecular mechanisms of regulation of genes that are important in the pathophysiology of the lung diseases. I am also interested in the effects, mechanisms of action and therapeutic potential of drugs that target these genes. I have published over 35 articles in scientific journals and am currently on the editorial board of the American Journal of Respiratory Cell and Molecular Biology. Our work is supported by research grants from a number of sources including Medical Research Council, the Wellcome Trust, Btitish Lung Foundation and Asthma UK.

Past Research

Future Research

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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