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Susanti Susanti

PhD student (Cancer and Stem Cells), Faculty of Medicine & Health Sciences

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Biography

A Pharmacist professional degree fortified by M Phil in Medical research offered a thorough understanding of translational medicine and its potential to revolutionize the way diseases are treated. Previous medical research experience at Australian National University (ANU) and current PhD studentship in University of Nottingham (UoN) channelize my future research in cancer, vascular biology and immunology. A stint as a junior lecturer, member of various teams and an entrepreneur pharmacist polished my interpersonal and communication skills.

AWARDS:

  • Australian Development Scholarship 2009 for M.Phil degree.
  • Trans-Youth Travel Fund by Federation of European Biochemical Societies (FEBS) 2012 to attend FEBS Workshop on Moleculer and Celluler Mechanism in Angiogenesis, 14-17 October 2012, Capri, Italy.
  • Travel Fellowship by Federation of Asian and Ocenian Biochemists and Molecular Biologists (FAOBMB) to attend The 2013 Special FAOBMB Symposium, 16-17 December 2013, Nasional University Singapore (NUS), Singapore
  • Islamic Development Bank (IDB) Merit Scholarship for PhD Programme, 2014

Research Summary

Investigating the interactions between tumour cells and the non-tumour cellular community in colorectal cancer

Colorectal cancer (CRC) or sometimes also called bowel cancer is one of the leading causes of cancer-related mortality. According to Cancer Research UK, CRC is the fourth most common cancer and accounts for approximately 12 % of all new cases. CRC is also a heterogeneous disease and the most recent classification has identified 4 tumour groups which has been called "Consensus Molecular Subtypes (CSM)". CSM 1 is comprised of tumours which have microsatellite instability (MSI) and which develop along a well described genetic pathway. CMS 2- 4 are microsatellite stable (MSS) and are distinguished from each other by a variety of molecular features. As well as molecular differences in the epithelium, there are also differences in the stroma between the CMS groups. The best known is the difference in the lymphocytic infiltrate between MSI and MSS tumours. The role and profile of other cellular populations (such as cells of the innate immune system) and the activated signalling pathways in these groups is uncertain.

This project will investigate the hypothesis that (i) the cellular community in CRCs in non-random and is dictated by signals from the epithelium and (ii) that reciprocally, the cellular community (in particular the cells related to adaptive immunity) can influence tumour kinetics. We will focus on the mapping of cellular community in microenvironment of the different CMS types of colorectal tumours and will aim to look for association with the genetic/ molecular profiles. In addition, we will investigate the importance of the plasticity of macrophages as the primary player of innate immunity, in CRC biology.

School of Medicine

University of Nottingham
Medical School
Nottingham, NG7 2UH

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