Medical Research Council<br>Institute of Hearing ResearchMedical Research Council
Institute of Hearing Research
Nottingham | Glasgow
Medical Research Council<br>Institute of Hearing ResearchMedical Research Council
Institute of Hearing Research
Nottingham | Glasgow
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Location
MRC Institute of Hearing Research Seminar Room
Date(s)
Tuesday 25th April 2017 (13:00-14:00)
Contact

Peyman.adjamian@nottingham.ac.uk

Description

Seminar: Electrophysiological Imaging of Tinnitus from Cochlea to Brain

This seminar will be presented by Professor Larry E. Roberts (Department of Psychology, Neuroscience and Behaviour, McMaster University,  Hamilton, Ontario, Canada).

While most (arguably all) cases of chronic tinnitus are related to some form of peripheral hearing pathology, the tinnitus percept itself is generated not by increased pathological neural activity occurring in the cochlea but by neuroplastic changes that occur in central auditory structures when the brain loses its input from the ear.   Neural changes seen in primary auditory cortex appear to relate most closely to the tinnitus percept while those observed in other brain regions reflect the consequences of tinnitus-related neural activity for cognitive and emotional processing or correlated attributes of tinnitus including somatosensory modulation and hyperacusis.  Communication among and within these brain regions gives rise to oscillatory dynamics expressed in various frequency bands.  Although there is controversy, a case can be made that the trigger for these dynamics is cochlear pathology that may or may not express in the clinical audiogram.  Because neural changes at different levels occur in the same structure (the brain), they must relate to one another in some way.   I will try to make that case.  Electrophysiological imaging of the auditory midbrain combined with cochlear modeling suggests a potential window on hidden synaptic loss in the cochlea that may explain tinnitus observed with clinically normal hearing thresholds.  (Supported by NSERC of Canada)

Medical Research Council Institute of Hearing Research

Email: enquiries@ihr.nottingham.ac.uk

The MRC Institute of Hearing Research is part of The University of Nottingham, funded through a strategic partnership between the Medical Research Council and the University. The MRC/CSO Institute of Hearing Research – Scottish Section is part of The University of Nottingham, funded through a strategic partnership between the Medical Research Council, the Chief Scientist Office and the University.

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