Professor Arthur Rowe
Profile
Professor Arthur Rowe
Profile
Professor Arthur Rowe, the Director of the NCMH Business Centre, worked for many years in the School of Biological Sciences at the University of Leicester, where he was Director of both the NCMH Leicester Laboratory and the Biological Sciences Electron Microscope Laboratory. In conjunction with both areas, he built up a steady level of interaction with industrial companies, in addition to contributing to his special fields of interest. He founded the MSc (Biomolecular Technology) at Leicester, a Course given jointly with both the University of Nottingham and with a wide range of participating industrial enterprises.
Starting with degrees in Biochemistry and in Colloid Science, Arthur has spent much of research career in studies on the proteins involved in cell motility, especially myosin and ciliary dynein (the latter jointly described and named by Gibbons & Rowe, 1965, during a period as a Fellow in Biology at Harvard University). In his solution studies on proteins, the analytical ultracentrifuge has been a major technique used, and he has contributed via many practical and theoretical papers in this field, and as a contributor to and co-editor of a major modern work compendium ("The Analytical Ultracentrifuge in Biochemistry and Polymer Science", eds Harding, Rowe & Horton, RSC, 1992). In latter years, Arthur's fields of interest have broadened to include properties of cytoskeletal and membrane-interacting (bacterial toxin) proteins.
Arthur was, many years ago, the first scientist to observe IgG antibodies 'in action' on a macromolecular system, and was jointly responsible for seeing and naming the 'hinge' region of IgG (Feinstein & Rowe, Nature, 1965). He still retains an interest in electron microscopy and visiting status in Leicester's EM Laboratory (now in the Faculty of Medicine & Biological Sciences).
A few of Arthur's recent papers are listed below:
Peter J Morgan, Stefan C Hyman, Arthur J Rowe, Timothy J Mitchell, Peter
W Andrew & Helen R Saibil (1995) Subunit organisation and symmetry
of pore-forming, oligomeric pneumolysin FEBS Letters 371 77-80
G Flood, E Kahana, A P Gilmore, A J Rowe, W B Gratzer & D R Critchley
(1995) "Association of Structural Repeats in the a-actinin Domain. Alignment
of Inter-Subunit Interactions." J Molec Biol 252 227-234
O Byron & A J Rowe (1995) "Macromolecular solution conformation from
hydrodynamic bead modelling studies" Protein Science 4(supp 1): p.52.
Stephen E Harding & Arthur J Rowe (1996) "Active Enzyme Centrifugation"
in Enzymology LabFax (Eds B D Hames & D Rickwood) pp 66-70 bios Scientific
Publishers
M D Brownleader, O Byron, A J Rowe, M Trevan, K Welham & P M Deys (1996)
"Investigations into the molecular size and shape of tomato extensin" Biochem
J 320 577-583
A C Clewlow, N Errington & A J Rowe (1997) "Analysis of data captured
by an on-line image capture system from an analytical ultracentrifuge using
schlieren optics" Eur Biophys J 25 311-318
G Flood, A J Rowe, D R Critchley & W B Gratzer (1997) "Further analysis
of the role of spectrin repeat motifs in a-actinin dimer formation" Eur
Biophys J 25 431-436
H Silkowski, S J Davis, A N Barclay, A J Rowe, S E Harding & O Byron
(1997) "Characterisation of the low affinity interaction between rat cell
adhesion molecules CD2 and CD48 by analytical ultracentrifugation" Eur
Biophys J 25 455-462
Peter J Morgan, Gayle Harrison, Primrose P E Freestone, Dennis Crane, Arthur
J Rowe, Timothy J Mitchell, Peter W Andrew & Robert J C Gilbert (1997)
"Structural and functional Characterisation of two proteolytic fragments
of the bacterial protein toxin, pneumolysin" FEBS Letters 412 563-567
H Tharia, O.D. Byron, A J Rowe & C Wells (1997) "Physical characterisation
and ATPase activity of 14S dynein fractions from Tetrahymena thermophylus"
J Musc Res Cell Motil 18 697-709
Georges M Pavlov, Arthur J Rowe & Stephen E Harding (1997) "Conformation
zoning of large molecules using the analytical ultracentrifuge" Trends
in Analytical Chemistry, 16 401-405
O W D Ertegruhl, N Errington, S Raza, M J Sutcliffe, A J Rowe & N S
Scrutton (1998) "Probing the stabilizing role of C-terminal residues in
trimethylamine dehydrogenase" Protein Engineering 11 447-455
J Rossjohn, R J C Gilbert, D Crane, P J Morgan, T J Mitchell, A J Rowe,
P W Andrew, R K Tweten & M W Parker (1998) "The molecular mechanism
of pneumolysin, a virulence factor from Streptococcus pneumoiae
J Mol Biol 284 449-461
Robert J. C. Gilbert, Jamie Rossjohn, Michael W. Parker, Rodney K. Tweten,
Peter J. Morgan, Timothy J. Mitchell, Neil Errington, Arthur J. Rowe, Peter
W. Andrew and Olwyn Byron (1998) "Self-interaction of Pneumolysin, the
Pore-forming Protein Toxin of Streptococcus pneumoniae" J. Mol. Biol. (1998)
284 1223-1237