Nottingham Clinical Trials Unit
The University of Nottingham
University of Nottingham
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MUSCULOSKELETAL

 

Trial Name: Nottingham Gout Treatment Phase 2: trial of a nurse-lead package of care

 Chief Investigator:  Michael Doherty, The University of Nottingham

 Trial Description:  Gout is often said to be the most painful form of arthritis. Symptoms include intensely painful, red, hot and swollen joints. Gout is most common in men and rarely affects women before the menopause. Prevalence increases with age. Of all the forms of arthritis gout is understood the best. This has led to a range of therapies to treat acute attacks and control the condition. People with gout are usually managed in primary care, but their care is not always optimal.

This trial to asses whether, for patients with untreated or under-treated gout, nurse led care is effective and cost-effective compared with usual general practitioner-led care. Estimated sample size was initially 724 participants, but this was subsequently revised to 512 participants. The primary outcome was serum uric acid within the therapeutic range (<360 µmol/L) at two years. Recruitment was from March 2013 to October 2014, in total 517 participants were recruited.

 Contact:  Lelia Duley

 Funding: Arthritis Research UK

 Status:  Follow up

 Further Information:  ctu@nottingham.ac.uk

 

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Trial Name:  Needle fasciotomy versus limited fascietomy for treatment of Dupuytren's contractures of the fingers: a feasibility study to investigate the acceptability and design of a multicentre randomised trial (HAND-1)

 Chief Investigator:  Tim Davis, Nottingham University Hospitals NHS Trust

 Trial Description: Dupuytren's contractures are fibrous cords under the skin in the palm of the hand. These contractures are painless but cause one or more fingers to gradullay and irreversibly curl into the palm, resulting in loss of hand function. Standard treatment is surgery to either remove or divide the contractures, allowing the finger to straighten again. The most common operation is to remove the contracture (limited fasciectomy): the fibrous cords preventing the finger(s) from straightening are cut out through a long skin incision in the hand, The alternative procedure is to divide the contracture with a needle (needle fasciotomy): a needle is put through the skin and sawing movements used to divide the fibrous cords. There is no clear evidence of the comparative benefirs and risks of these two quite different surgical procedures for Dupuytren's contractures.

The HAND-1 study aims to assess the feasibility and acceptability to patients and clinicans of conducting a large randomised trial assessing the comparative clinical and cost effectiveness of needle fascietomy versus limited fasciectomy for Dupuytren's contractures of fingers. Recruitment is from November 2015 to September 2016 at three sites, and the total sample size is 50 to 85 participants.

 Contact:  Ellie Harrison

 Funding:  NIHR Research to Patient Benefit

 Status: Recruiting

 Further Information:  Ellie Harrison (Trial Manager) Hand-1@nottingham.ac.uk

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Nottingham Clinical Trials Unit

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