logo

Largest mass extinction linked to 21st century lung cancer epidemic

   
   
20 Nov 2009 10:57:00.000

The geologic conditions that very nearly annihilated life 250 million years ago are still killing people today.

Parts of Xuan Wei County in Yunnan Province in China have the world"€™s highest known death rates from lung cancer in non-smoking women. For thirty years the region, which uses locally mined coal for domestic cooking and heating, has been the focus of intense scientific research to establish a cause.

Now a team of experts led by The University of Nottingham have discovered that high concentrations of fine grained silica found in the coal which is produced from the uppermost Permian coal seam, correlate directly with lung cancer mortality rates. The results of their two year study, funded by UK Office of Science and Innovation through the Royal Society, have been published in the journal Environmental Science & Technology.

Click here for full story

Dr David Large from the Department of Chemical and Environmental Engineering said: “Our work is a major break-through that points to a new research direction and a new way of addressing the problem. Our discovery does not, in itself, solve the problem — that is for future work. However we hope that the interest generated by these results will open doors to new research opportunities. Successful future work depends on being able to build an appropriate interdisciplinary team with fuel scientists, geologists, medics and epidemiologists.”

 

In Xuan Wei coal is used for domestic cooking and heating filling the air within the home with ash and volatiles. Over the past two decades excellent measures have been taken to improve living standards in Xuan Wei and provide better ventilation in dwellings. However, the lung cancer mortality rate shows no sign of diminishing. In turn, this is hampering development in a region that, like most of China, is dependent on coal as the primary energy resource.

 

The exceptional lung cancer mortality rate has, for many years, been attributed to high concentrations of Polycyclic Aromatic Hydrocarbons (PAHs) — produced when domestic coal is burnt. But the association between PAH levels in the smoke and cancer mortality is very weak and the team led by The University of Nottingham began the search for other causes.

 

Dr Large said: “Future work should investigate the interaction of organic compounds and dust particles a topic that is of global significance. For example fine grained silica was recently declared a carcinogen. This was highly controversial as many believe that silica cannot cause cancer. Others believe that silica causes cancer when other compounds like aromatic hydrocarbons are involved. Xuan Wei provides an ideal opportunity to understand such an interaction.  Another line of research is to use our approach to quantify the risk posed by coals worldwide.

 

“To reduce the risk to the people in China they need to reduce their exposure to the ash, so any practical way that addresses this would help. The first step would be awareness that the ash is hazardous, then in conjunction with the population consider practical ways of reducing ash exposure.”

 

The research was carried out in collaboration with the Division of Epidemiology and Public Health, at The University of Nottingham, the Department of Mineralogy at the Natural History Museum in London, the School of Public Health, Chinese University of Hong Kong, the State Key Laboratory of Coal Resources and Safe Mining, China University of Mining and Technology, Beijing, The University of Texas at Dallas and the Yunnan Institute of Coal Geology Prospection, China.

 

— Ends —

 

Notes to editors: The University of Nottingham is ranked in the UK's Top 10 and the World's Top 100 universities by the Shanghai Jiao Tong (SJTU) and Times Higher (THE) World University Rankings.

 

More than 90 per cent of research at The University of Nottingham is of international quality, according to RAE 2008, with almost 60 per cent of all research defined as ‘world-leading’ or ‘internationally excellent’. Research Fortnight analysis of RAE 2008 ranks the University 7th in the UK by research power. In 27 subject areas, the University features in the UK Top Ten, with 14 of those in the Top Five.

 

The University provides innovative and top quality teaching, undertakes world-changing research, and attracts talented staff and students from 150 nations. Described by The Times as Britain's “only truly global university”, it has invested continuously in award-winning campuses in the United Kingdom, China and Malaysia. Twice since 2003 its research and teaching academics have won Nobel Prizes. The University has won the Queen's Award for Enterprise in both 2006 (International Trade) and 2007 (Innovation — School of Pharmacy), and was named ‘Entrepreneurial University of the Year’ at the Times Higher Education Awards 2008.

 

Nottingham was designated as a Science City in 2005 in recognition of its rich scientific heritage, industrial base and role as a leading research centre. Nottingham has since embarked on a wide range of business, property, knowledge transfer and educational initiatives (www.science-city.co.uk) in order to build on its growing reputation as an international centre of scientific excellence. The University of Nottingham is a partner in Nottingham: the Science City.

 

Story credits

More information is available from Dr David Large on +44 (0)115 951 4114 david.large@nottingham.ac.uk

Lindsay Brooke

Lindsay Brooke - Media Relations Manager

Email: lindsay.brooke@nottingham.ac.uk Phone: +44 (0)115 951 5751 Location: University Park

Additional resources

No additional resources for this article

Related articles

Launch for joint UK-China research lab on biomimetics

Published Date
Thursday 22nd January 2009

Protecting humans and animals from diseases in wildlife

Published Date
Thursday 1st October 2009

Shanghai visiting professorship for pharmacy researcher

Published Date
Monday 24th August 2009

Experts put Chinese medicine in the spotlight

Published Date
Tuesday 18th August 2009

Revolutionising the diagnosis of serious disease

Published Date
Tuesday 2nd June 2009

Creating 'green manufacturing' partnerships at Shanghai Expo

Published Date
Wednesday 23rd June 2010

The University of Nottingham counts down to Shanghai Expo

Published Date
Tuesday 16th March 2010

News and Media - Marketing, Communications and Recruitment

The University of Nottingham
C Floor, Pope Building (Room C4)
University Park
Nottingham, NG7 2RD

telephone: +44 (0) 115 951 5765
email: communications@nottingham.ac.uk