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Prestigious award to support regenerative medicine research

   
   
Professor Kevin Shakesheff in the laboratory
08 Feb 2013 00:01:00.000
PA 37/13

A Nottingham professor has received a prestigious award from the Royal Society that will support his research into the development of a new generation of regenerative medicines.

Kevin Shakesheff, Head of The University of Nottingham’s School of Pharmacy and Professor of Drug Delivery and Tissue Engineering, is one of 25 new Royal Society Wolfson Research Merit Award holders.

Jointly funded by the Wolfson Foundation and the Department for Business, Innovation and Skills (BIS), the scheme aims to provide universities with additional support to help them attract science talent from overseas and retain respected UK scientists who have demonstrated outstanding achievement and potential.
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Professor Shakesheff said: “This award is a major boost at a time when we are very excited about the potential of stem cells as future medicines.”

Reversing tissue damage

The award recognises Professor Shakesheff’s expertise in developing new types of medicine that cause damaged or diseased tissues to regenerate. For many diseases, including heart attacks, spinal cord damage and loss of blood vessels in long term diabetes, there are no current treatments that reverse the loss of tissues. As a result the patient has to live with poor function in key tissues and the symptoms of the diseases are treated but not cured.

Professor Shakesheff is part of a worldwide effort to find new types of medicines that do reverse tissue damage. The scientific foundation of his work is the fact that all human tissues spontaneously self-assemble during the development of the embryo and foetus. Therefore, within the cells of the body there is a silenced ability to form tissues.

Professor Shakesheff added: “New therapies using stem cells as ‘living drugs’ are beginning to make a clinical impact in treatment and trials for the repair of cartilage, bone, heart, nerve and other tissues. However, there is a huge gap between the ability of an embryo to form a tissue and the efficacy of the best stem cell therapies in regenerative medicine. My research group is aiming to learn from the process of human tissue development and apply findings to the design of stem cell medicines.”

Promising results

For example, within the embryo tissue patterning to form early stage organs is driven by protein molecules that are released in precise locations at precise times. Using advanced materials it is possible to replicate this type of control but outside of an embryo. This can be used to accelerate the formation of blood vessels and complex human tissues.

Professor Shakesheff’s groups are translating these advanced materials into products for the stem cell industry and for new therapies. Promising, but early, results in animal models have been published on stroke recovery, reformation of blood vessels, accelerating heart cell formation and constructing new bone.

The new award is focussed on learning more from the embryo with the aim of informing the design of stem cell therapies that may transform many aspects of medicine over the next 50 years.

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Notes to editors: The University of Nottinghamhas 42,000 students at award-winning campuses in the United Kingdom, China and Malaysia. It was ‘one of the first to embrace a truly international approach to higher education’, according to the Sunday Times University Guide 2013. It is also one of the most popular universities among graduate employers, one of the world’s greenest universities, and winner of the Times Higher Education Award for ‘Outstanding Contribution to Sustainable Development’. It is ranked in the UK's Top 10 and the World's Top 75 universities by the Shanghai Jiao Tong and the QS World Rankings.

More than 90 per cent of research at The University of Nottingham is of international quality, according to the most recent Research Assessment Exercise. The University aims to be recognised around the world for its signature contributions, especially in global food security, energy & sustainability, and health. The University won a Queen’s Anniversary Prize for Higher and Further Education for its research into global food security.

Impact: The Nottingham Campaign, its biggest ever fundraising campaign, will deliver the University’s vision to change lives, tackle global issues and shape the future. More news…

 

Story credits

More information is available from Professor Kevin Shakesheff on +44 (0)115 951 5101, kevin.shakesheff@nottingham.ac.uk
Emma Thorne

Emma Thorne - Media Relations Manager

Email: emma.thorne@nottingham.ac.uk Phone: +44 (0)115 951 5793 Location: University Park

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