School of Human Development - University of Nottingham


			Division of Human Development

GRUNDY, Richard Guy

Professor of Paediatric Neuro-oncology and Cancer Biology

BSc, MB ChB, Ph.D., FRCPCH

Child Health, Queen’s Medical Centre Campus

Email:            richard.grundy@nottingham.ac.uk
Telephone:     0115 823 0717
Fax:               0115 823 0696

Address:

Children’s Brain Tumour Research Centre
D Floor, Medical School
Nottingham University Hospitals NHS Trust
Queen’s Medical Centre Campus
Nottingham.
NG7 2UH

Research Profile:

The Children’s Brain Tumour Research Centre (CBTRC)

The Centre links over 60 researchers from eight departments across the University and Nottingham and Nottingham University Hospital Trust Departments conducting clinical and scientific research directed at increasing our understanding of the biological nature of childhood brain tumours and using this knowledge to optimize the health outcomes for the child and family. In a forward looking multidisciplinary research programme linking basic science to patient centered care we are currently testing hypotheses concerned with neurodevelopment, tumour biology, health services research linked to processes of referral at diagnosis, application of novel imaging and genetic techniques aimed at comprehensive assessment of tumour biology, optimisation of drug selection and CNS targeting, clinical trials of novel therapies, classification of specific brain injury syndromes and techniques for their limitation as well as the development and application of methods for measuring health outcomes during and after treatment as experienced by children and young people.

In May 2005, the University appointed Professor Grundy as Professor of Paediatric Neuro-Oncology, the first such chair in Europe, bringing a substantial cancer genetic translational research programme linking basic science to patient care

Publications (2004-2007)

Peet, A.C Davies,, Ridley,L, Brundler,, Kombogiorgas,, Lateef,, Natarajan,, Sgouros,, Macpherson, and Grundy, R, 2007. Magnetic Resonance Spectroscopy Suggests Key Differences In The Metastatic Behaviour Of Medulloblastoma. European Journal Of Cancer, 43(6), 1037-1044

Peet, A.C., Mcconville C., Wilson M., Levine B.A., Reed M., Dyer S.A., Edwards E.C., Strachan M.C., Mcmullan D.J., Wilkes T.M. and Grundy R.G., 2007. MRS identifies specific metabolite profiles associated with MYCN-amplified and non-amplified tumour subtypes of neuroblastoma cell lines. NMR Biomed.

Ng,A., Griffith,A., Cole.T,, Davison,V., Griffiths,M., Larkin,S., Parkes,S.E., Mann,J.R. and Grundy,R.G., 2007. Congenital abnormalities and clinical features associated with Wilms' tumour: A comprehensive study from a centre serving a large population. Eur J Cancer.

Mcmanamy,C.S., Pears,J., Weston,C.L., Hazely,A., Ironside,J.W., Taylor,R.E., Grundy,R.G., Clifford,S.C. and Ellison,D.W., 2007. Nodule formation and desmoplasia in medulloblastomas-defining the nodular/desmoplastic variant and its biological behaviour. Brain Pathology, 2, 151-164

Kombogiorgas D, Sgouros S, Walsh Ar, Hockley Ad, Stevens M, Grundy R, Peet A, English M, Spooner D, 2007. Outcome of children with posterior fossa medulloblastoma: a single institution experience over the decade 1994-2003. Childs Nervous System, 23(4), 399-405

Grundy, R.G., Wilne, S.A., Weston, C., Robinson, K., Lashford, L., Ironside, J., Cox, T., Chong, W.K., Campbell, R.H.A., Bailey, C.C., Gattamaneni, R., Picton, S., Thorpe, N., Mallucci, C., English, M.W., Punt, J.A.G., Walker, D.A., Ellison, D.W. And Machin, D., 2007. Primary postoperative chemotherapy without radiotherapy for intracranial ependymoma in children: the UKCCSG/SIOP prospective study. Lancet Oncology, 8(8), 696-705

Wilne, S., Collier, J., Kennedy, C., Koller, K., Grundy, R. and Walker, D., 2007. Presentation of childhood CNS tumours: a systematic review and meta-analysis. Lancet Oncology, 8(8), 685-695.

Sharif, K., Ramani, P., Lochbuhler, H., Grundy, R. And De Ville De Goyet, J., 2006. Recurrent Mesenchymal Hamartoma Associated with 19q Translocation. A Call for More Radical Surgical Resection. European Journal of Pediatric Surgery, 16(1), 64-67.

Langdon, J.A., Lamont, J.M., Scott, D.K., Dyer, S., Prebble, E., Bown, N., Grundy, R.G., Ellison, D.W. And Clifford, S.C., 2006. Combined genome-wide allelotyping and copy number analysis identify frequent genetic losses without copy number reduction in medulloblastoma. Genes, Chromosomes and Cancer, 45(1), 47-60

Mitchell, C., Pritchard-Jones, K., Shannon, R., Hutton, C., Stevens, S., Machin, D., Imeson, J., Kelsey, A., Vujanic, G.M., Gornall, P., Walker, J., Taylor, R., Sartori, P., Hale, J., Levitt, G., Messahel, B., Middleton, H., Grundy, R. And Pritchard, J., 2006. Immediate nephrectomy versus preoperative chemotherapy in the management of non-metastatic Wilms' tumour : results of a randomised trial (UKW3) by the UK Children's Cancer Study Group. European Journal of Cancer, 42(15), 2554-2562.

Ng, Antony, Nishikawa, Hiroshi, Lander, Anthony and Grundy, Richard, 2005. Chemosensitivity in pediatric dermatofibrosarcoma protuberans. Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology, 27(2), 100-2.

Peet, A. C., Leach, M. O., Pinkerton, C. R., Price, P., Williams, S. R. And Grundy, R. G., 2005. Proceedings of the Engineering and Physical Sciences Research Council Workshop-The Development of Functional Imaging in the Diagnosis, Management and Understanding of Childhood Brain Tumours.
PEDIATRIC BLOOD AND CANCER, 44(2), 103-113.

Seale, C., Kirk, D., Tobin, M., Burton, P., Grundy, R., Pritchard-Jones, K. and Dixon-Woods, M., 2005. Effect of media portrayals of removal of children's tissue on UK tumour bank. BMJ, 331(7513), 401-403.

Astuti,D., Latif,F., Wagner,K., Gentle,D., Cooper,W.N., Catchpole,D., Grundy,R.G., Ferguson-Smith,A.C. and Maher,E.R., 2005. Epigenetic alteration at the DLK1-GTL2 imprinted domain in human neoplasia provides evidence for trans interation between DLK1 and GLT2 oncogene. Oncogene.

Astuti, D., Latif, F., Wagner, K., Gentle, D., Cooper, W. N., Catchpoole, D., Grundy, R., Ferguson-Smith, A. C. and Maher, E. R., 2005. Epigenetic alteration at the DLK1-GTL2 imprinted domain in human neoplasia: analysis of neuroblastoma, phaeochromocytoma and Wilms' tumour. British Journal of Cancer, 92(8), 1574-1580.

Cooper, Wendy N, Luharia, Anita, Evans, Gail A, Raza, Hussain, Haire, Antonita C, Grundy, Richard, Bowdin, Sarah C, Riccio, Andrea, Sebastio, Gianfranco, Bliek, Jet, Schofield, Paul N, Reik, Wolf, Macdonald, Fiona and Maher, Eamonn R, 2005. Molecular subtypes and phenotypic expression of Beckwith-Wiedemann syndrome. European Journal of Human Genetics, 13(9), 1025-32.

Wilne, S., Collier, J., Walker, D., Grundy, R., Kennedy, C. and Punt, J., 2005. The presentation of childhood brain tumors: a meta-analysis. Neuro-oncology, 7(3), 335

Chantada,G., Doz,F., Antoneli,C.B., Grundy,R.G., Clarestannard,F.F., Dunkel,I.J., Grabowski,E., Lealleal,C., Rodriguez-Galindo,C., Schvartzman,E., Popovic,M.B., Kremens,B., Meadows,A.T. and Zucker,J.M, 2005. A proposal for an international retinoblastoma staging system. Paediatric Blood and Cancer, 47(6), 801-805.

Grundy, R. G., Hutton, C., Middleton, H., Imeson, J., Pritchard, J., Kelsey, A., Marsden, H. B., Vujanic, G. M., Taylor, R. E. and Ukccsg, 2004. Outcome of Patients With Stage III or Inoperable WT Treated on the Second United Kingdom WT Protocol (UKWT2); A United Kingdom Children's Cancer Study Group (UKCCSG) Study. PEDIATRIC BLOOD AND CANCER, 42(4), 311-319.

Veal, G. J., English, M. W., Grundy, R. G., Shakespeare, C., Glaser, A., Waters, F., Holden, V., O Meara, A., Michalski, A. and Howe, K., 2004. Pharmacokinetically guided dosing of carboplatin in paediatric cancer patients with bilateral nephrectomy. Cancer chemotherapy and pharmacology, 54(4), 295-