> Date:          Mon, 12 May 1997 10:53:07 -0700
> From:          aemich@rfhsm.ac.uk (Dr. Anthony Michael, Biochem,)
> Subject:       Ovarian Cortisol Metabolism

> 
> 	OVARIAN CORTISOL METABOLISM
> 
> For the past 5 years or so, we* have been investigating the ability of human
> granulosa-lutein cells (recovered from the follicular aspirates of women
> hyperstimulated for IVF) to metabolize the adrenal steroid cortisol...............

Is there any evidence for corticoteroid synthesis in the ovary, 
or is the 11ssHSD acting on exogenous cortisol alone? Are the 
enzyme kinetics optimal for circulating or FF concentrations of 
cortisol?

Marin Luck