Dementia with Lewy Bodies: Clinical, Pathological and Treatment Issues

Robert Perry

Ian McKeith

Elaine Perry

This book contains chapters from participants at the International Workshop on Dementia with Lewy Bodies held in Newcastle upon Tyne, 4-7 October 1995.

Contents

Introduction

Part 1: Clinical issues

• The clinical diagnosis and misdiagnosis of Lewy body dementia
• The nosological status of Lewy body dementia
• Putative clinical and genetic antecedents of dementia associated with Parkinson's disease
• Clinical features of patients with Alzheimer's disease and Lewy bodies
• The nature of the cognitive decline in Lewy body dementia
• Non-cognitive symptoms in Lewy body dementia
• Hallucinations, cortical Lewy body pathology, cognitive function and neuroleptic use in dementia
• Neuropsychological aspects of Lewy body dementia
• The neuroanatmical basis of cognitive decline in Lewy body dementia
• The clinical and functional imaging characteristics of Parkinsonism dementia
• Positron emission tomography findings in Parkinson's disease and Lewy body dementia
• Clinical features of diffuse Lewy body disease in the elderly and analysis of 12 cases
• Senile dementia of Lewy body type - clinical features and prevalence in neuropathological post-mortems
• Lewy body dementia in clinical practice
• Resume of workshop sessions

Part 2: Pathological issues

• Pathological significance of Lewy bodies in dementia
• Tautological tangles in neuropatholoc criteria for dementia associated with Lewy bodies
• What is the neuropathological basis of dementia associated with Lewy bodies
• Cytoskeletal and Alzheimer-type pathology in Lewy body disease
• Diffuse Lewy body disease within the spectrum of Lewy body disease
• Temporal lobe immunohistochemical pathology for tangle, plaques and Lewy bodies in diffuse Lewy body disease, Parkinson's disease and senile dementia of Alzheimer type.
• Pathological and clinical features of Parkinson's disease with and without dementia
• Dementia with Lewy bodies: relationship to Parkinson's disease and Alzheimer's disease
• What do Lewy bodies tell us about dementia and Parkinsonism
• Pathogenesis of the Lewy body
• Altered Tau processing: its role in development of dementia in Alzheimer's disease ande Lewy body disease.
• Cytoskeletal pathology in Alzheimer's disease and Lewy body dementia - an epiphenomenon?
• Genetic correlations in Lewy body disease
• Resume of pathological workshop sessions

Part 3: Treatment issues

• Psychopharmacology of cognitive impairment in Parkinson's disease
• Management of the non-cognitive symptoms of Lewy body dementia
• Altered consciousness and transmitter signalling in Lewy body dementia
• Cholinergic therapy and Lewy body dementia
• Clinical heterogeneity in dementia: responders to cholinergic therapy
• Tacrine and symptomatic treatment in Lewy body dementia
• Neurochemical correlates of pathological and iatrogenic extrapyramidal symptoms
• Neurotrophins and the cholinergic system in dementias
• Relevance of Lewy bodies to alterations in oxidative stress in Lewy body dementia and Parkinson's disease
• Resume of workshop sessions

Appendix