Organic and biological chemistry research at Nottingham is very broadly based, and spans the whole spectrum of activity from medicinal chemistry, target organic synthesis, catalysis and development of new synthetic methodology through to mechanistic enzymology, chemical genetics, protein biochemistry, protein engineering and structural biology. Organic chemistry is especially strong in the areas of target synthesis, natural product chemistry, and asymmetric synthesis. Complex natural products and their analogues continue to present a fascinating challenge to the synthetic chemist. Research groups at Nottingham are probing new strategies and developing new methodologies for the synthesis of such molecules, with emphasis on compounds with significant biological activity. In particular, we are interested in novel compounds with antibacterial, anticancer and antimalarial properties. In biological chemistry, we address problems at the interface of chemistry and biology, to define the molecular interactions that determine the specificity and control of biological processes. The department is well supported through UK Research Council and EU funding, and has strong links to the pharmaceutical industry. Key themes include:
Synthesis and Natural Products
The design and application of novel synthetic methodologies for the synthesis of naturally occurring target molecules, including antibiotics, alkaloids, terpenes and marine natural products.
Asymmetric Synthesis and Catalysis
The design of new reagents and catalysts to effect diastereoselective and enantioselective reactions, involving alkylations, C-H oxidation, reduction, and rearrangement processes.
Biological and Medicinal Chemistry
Studies of the fundamental properties of biomolecules, for example the folding of proteins and the binding of antibiotics to DNA; synthesis of enzyme inhibitors, antisense DNA, and hapten design for generation of catalytic antibodies. Novel compounds with antibiotic, anticancer and antimalarial properties.
The usual minimum requirement for PhD/MPhil entry is an upper 2nd class or first class honours degree (or International equivalent) in an MSci or MChem degree in chemistry.
The usual minimum requirement for MRes entry is a lower 2nd class honours degree (or International equivalent) in chemistry.
International research students need to achieve an IELTS score of 6.0 with no less than 5.5 in each element.
The University runs a number of preparatory English programmes each summer and, for extra support during your degree, you can attend its free language classes. For more information, visit our Centre for English Language Education (CELE).