School of Pharmacy
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Martin Garnett

Associate Professor, Faculty of Science

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Biography

I obtained my BSc in biochemistry at University College of Swansea (University of Wales) in 1974 and my Ph.D, based on studies on oxygen toxicity in 1981 at University College London. I then spent 10 years developing antibody drug conjugates in Cancer Research at Nottingham before joining the School of Pharmacy in 1991. I became Associate Professor in 2004.

My research interests include a wide range of drug delivery technologies based on polymers and nanotechnology involving both drug and nucleic acid delivery and including aspects of targeting. My research incorporates many aspects of drug delivery including assembly and characterisation of delivery systems, both the physicochemical and biological aspects. The chemical side includes polymer development and characterisation, and drug polymer interactions. The biological characterisation includes the interaction of the delivery systems with cells and tissues, the transport of nanoparticulates into and across cells and penetration in 3-dimensional cell models. Successful research projects have included

  • The development of a monoclonal antibody-HSA-Methotrexate conjugate with high in vitro potency and selectivity.
  • Development of self-assembling and self-crosslinking DNA and RNA delivery systems using a three component (polyamidoamine, polyamidoamine-PEG and nucleic acid) mixture. This system was successfully applied to a water tracing application.
  • Development of a new enzymically synthesised and enzymically degradable polymer with a pendant functional group (poly(glycerol-adipate) which can be functionalised with a range of moieties which has applications in many areas of drug delivery.

Expertise Summary

  1. Development of Antibody and polymer drug conjugates. I have expertise in chemical conjugation of drugs to polymers and immunoglobulins and also polymer-antibody conjugation and conjugate characterisation.

2. Assembly and characterisation of polyelectrolyte systems for nucleic acid (DNA/RNA) delivery systems based on positively charged polyamidoamine polymers. Also application of polyelectrolyte sysstems for other drug delivery applications.

3. Small molecule delivery and targeting. Incorporation of drugs into nanoparticles and microparticles for a range of delivery systems. The main area of work has involved incorporation of anticancer drugs into nanoparticles, particularly for application to brain tumour research.

4. Development and characterisation of a new biodegradable polymer, poly(glycerol adipate), with further functionalisation has been developed to incorporate a wider range of drugs more effectively. Also study of interactions between polymers and drugs, so that we can design and develop polymer based drug delivery systems more effectively.

5. Collaboration with Cell biologists in the development of 3-D culture systems for analysis of cytotoxicity, uptake and penetration of drug delivery systems into tissues.

Research Summary

Research interests are in drug delivery, mainly using polymer based delivery systems for site specific delivery, e.g. nanoparticles micelles and soluble polymer systems. This encompasses delivery… read more

Recent Publications

Current Research

Research interests are in drug delivery, mainly using polymer based delivery systems for site specific delivery, e.g. nanoparticles micelles and soluble polymer systems. This encompasses delivery systems for proteins, oligonucleotides and DNA in addition to more conventional drug molecules, and the use of biological effectors e.g.ligands and antibodies.

School of Pharmacy

University of Nottingham
University Park
Nottingham, NG7 2RD

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