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Drug Discovery
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Drug discovery and medicinal chemistry in the areas of oncology, cardiovascular disease, infection & immunity, respiratory disease, inflammation, neurodegenerative disease
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Peter Fischer
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Medicinal Chemistry
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Drug discovery and medicinal chemistry in the areas of oncology, cardiovascular disease, infection & immunity, respiratory disease, inflammation, neurodegenerative disease
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Peter Fischer
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High throughput compound screening
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High throughput compound screening: fully automated state-of-the-art facility for a managed compound collection (initially >100k diverse drug-like small molecules) currently being established
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Peter Fischer
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Computational Methods
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High performance computational methods for molecular modelling, nanomedicine and drug design
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Charles Laughton
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High performance computing
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Computational methods for molecular modelling, nanomedicine and drug design
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Charles Laughton
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Molecular modelling
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Computational methods for molecular modelling, nanomedicine and drug design
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Charles Laughton
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Structure-based ligand design
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Active Site Pressurisation (ASP): a new structure-based ligand design that takes into account target protein
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Charles Laughton
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Drug design
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Computational methods for molecular modelling, nanomedicine and drug design
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Charles Laughton
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Protein-protein interactions
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Characterisation of protein-protein and protein-ligand interactions. LXXLL and related motifs.
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Lodewijk Dekker , Stephanie Allen , David Heery
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Protein-ligand interactions
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Characterisation of protein-protein and protein-ligand interactions. LXXLL and related motifs.
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Lodewijk Dekker , Stephanie Allen , David Heery
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Enzymes
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Mechanism of enzymatic reactions, using X-ray crystallographyMechanism of enzymatic reactions, using X-ray crystallography
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Jonas Emsley
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Fluorescent ligand design
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Fluorescent ligand design
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Barrie Kellam
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Peptides
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Chemistry of peptides and peptidomimetics
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Weng Chan
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Peptidomimetics
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Chemistry of peptides and peptidomimetics
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Weng Chan
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Solid-phase synthetic chemistry
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Solid-phase and medium-throughput synthetic and analytical chemistry
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Shudong Wang
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Medium-throughput synthetic chemistry
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Solid-phase and medium-throughput synthetic and analytical chemistry
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Shudong Wang
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Analytical chemistry
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Solid-phase and medium-throughput synthetic and analytical chemistry
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Shudong Wang
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Protein Structure
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Protein structure determination by X-ray crystallography
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Jonas Emsley
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X-ray crystallography
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Protein structure determination by X-ray crystallography
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Jonas Emsley
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High throughput crystallisation robotics
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High throughput crystallisation robotics for X-ray diffraction studies
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Jonas Emsley
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Fluorescent assay technology
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Fluorescent assay technology
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Barrie Kellam
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Cellular pharmacology
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Cellular pharmacology
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Shudong Wang
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Generation of stable cell lines
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Generation of stable cell lines
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Shudong Wang
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NMR spectroscopy
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NMR spectroscopy
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Lee Hibbett
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Mass spectrometry (including LC-MS-MS)
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Mass spectrometry (including LC-MS-MS)
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Lee Hibbett
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High pressure liquid chromatography
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High pressure liquid chromatography
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Lee Hibbett
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