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Drug Discovery
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Drug discovery and medicinal chemistry in the areas of oncology, cardiovascular disease, infection & immunity, respiratory disease, inflammation, neurodegenerative disease
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Medicinal Chemistry and Structural Biology
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Peter Fischer
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Medicinal Chemistry
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Drug discovery and medicinal chemistry in the areas of oncology, cardiovascular disease, infection & immunity, respiratory disease, inflammation, neurodegenerative disease
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Medicinal Chemistry and Structural Biology
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Peter Fischer
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High throughput compound screening
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High throughput compound screening: fully automated state-of-the-art facility for a managed compound collection (initially >100k diverse drug-like small molecules) currently being established
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Medicinal Chemistry and Structural Biology
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Peter Fischer
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Computational Methods
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High performance computational methods for molecular modelling, nanomedicine and drug design
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Medicinal Chemistry and Structural Biology
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Charles Laughton
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High performance computing
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Computational methods for molecular modelling, nanomedicine and drug design
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Medicinal Chemistry and Structural Biology
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Charles Laughton
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Molecular modelling
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Computational methods for molecular modelling, nanomedicine and drug design
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Medicinal Chemistry and Structural Biology
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Charles Laughton
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Structure-based ligand design
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Active Site Pressurisation (ASP): a new structure-based ligand design that takes into account target protein
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Medicinal Chemistry and Structural Biology
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Charles Laughton
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Drug design
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Computational methods for molecular modelling, nanomedicine and drug design
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Medicinal Chemistry and Structural Biology
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Charles Laughton
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Protein-protein interactions
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Characterisation of protein-protein and protein-ligand interactions. LXXLL and related motifs.
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Medicinal Chemistry and Structural Biology
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Lodewijk Dekker , Stephanie Allen , David Heery
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Protein-ligand interactions
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Characterisation of protein-protein and protein-ligand interactions. LXXLL and related motifs.
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Medicinal Chemistry and Structural Biology
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Lodewijk Dekker , Stephanie Allen , David Heery
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Enzymes
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Mechanism of enzymatic reactions, using X-ray crystallographyMechanism of enzymatic reactions, using X-ray crystallography
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Medicinal Chemistry and Structural Biology
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Jonas Emsley
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Fluorescent ligand design
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Fluorescent ligand design
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Medicinal Chemistry and Structural Biology
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Barrie Kellam
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Peptides
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Chemistry of peptides and peptidomimetics
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Medicinal Chemistry and Structural Biology
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Weng Chan
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Peptidomimetics
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Chemistry of peptides and peptidomimetics
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Medicinal Chemistry and Structural Biology
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Weng Chan
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Protein Structure
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Protein structure determination by X-ray crystallography
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Medicinal Chemistry and Structural Biology
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Jonas Emsley
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X-ray crystallography
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Protein structure determination by X-ray crystallography
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Medicinal Chemistry and Structural Biology
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Jonas Emsley
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High throughput crystallisation robotics
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High throughput crystallisation robotics for X-ray diffraction studies
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Medicinal Chemistry and Structural Biology
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Jonas Emsley
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Fluorescent assay technology
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Fluorescent assay technology
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Medicinal Chemistry and Structural Biology
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Barrie Kellam
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NMR spectroscopy
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NMR spectroscopy
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Medicinal Chemistry and Structural Biology
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Lee Hibbett
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Mass spectrometry (including LC-MS-MS)
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Mass spectrometry (including LC-MS-MS)
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Medicinal Chemistry and Structural Biology
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Lee Hibbett
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High pressure liquid chromatography
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High pressure liquid chromatography
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Medicinal Chemistry and Structural Biology
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Lee Hibbett
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Biomedical materials
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Biomaterials and biosurfaces for biomedical applications
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Biophysics and Surface Analysis
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Morgan Alexander
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Surface chemical characterisation
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Surface chemical characterisation
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Biophysics and Surface Analysis
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Morgan Alexander
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Surface chemical modification
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Surface chemical characterisation
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Biophysics and Surface Analysis
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Morgan Alexander
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Nanoscale characterisation
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Nanoscale characterisation and imaging
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Biophysics and Surface Analysis
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Clive Roberts
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Nanoscale imaging
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Nanoscale characterisation and imaging
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Biophysics and Surface Analysis
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Clive Roberts
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Crystallisation
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Crystallisation
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Biophysics and Surface Analysis
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Martyn Davies
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Protein folding & unfolding
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Protein folding & unfolding
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Biophysics and Surface Analysis
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Phil Williams
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Polymorphs
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Polymorph screening and materials characterisation
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Biophysics and Surface Analysis
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Jonathan Burley
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Fluorescence sensing
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Fluorescence sensing
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Biophysics and Surface Analysis
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Jonathan Aylott
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Chemical sensors and biosensors
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Chemical sensors and biosensors
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Biophysics and Surface Analysis
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Jonathan Aylott
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Atomic force microscopy
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Atomic force microscopy (including environmental control options)
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Biophysics and Surface Analysis
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Clive Roberts
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Scanning thermal microscopy
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Scanning thermal microscopy. Differential scanning calorimetry and nanothermal analysis.
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Biophysics and Surface Analysis
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Clive Roberts
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Differential scanning calorimetry
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Scanning thermal microscopy. Differential scanning calorimetry and nanothermal analysis.
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Biophysics and Surface Analysis
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Clive Roberts
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Nanothermal analysis
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Scanning thermal microscopy. Differential scanning calorimetry and nanothermal analysis.
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Biophysics and Surface Analysis
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Clive Roberts
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Optical tweezers
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Optical tweezers
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Biophysics and Surface Analysis
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Clive Roberts
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Surface plasmon resonance
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Surface plasmon resonance
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Biophysics and Surface Analysis
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Clive Roberts
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X-ray powder diffraction
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X-ray powder diffraction
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Biophysics and Surface Analysis
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Clive Roberts
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Confocal Raman spectroscopy
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Confocal Raman spectroscopy, including variable temperature and spatial mapping
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Biophysics and Surface Analysis
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Phil Williams , Jonathan Burley
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Biopharmaceuticals
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Biopharmaceuticals design, characterisation and formulation
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Biophysics and Surface Analysis
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Stephanie Allen
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UV/Vis spectroscopy
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UV/vis and IR spectroscopy, including PM IRRAS and ATR.
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Biophysics and Surface Analysis
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Morgan Alexander
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IR spectroscopy
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UV/vis and IR spectroscopy, including PM IRRAS and ATR.
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Biophysics and Surface Analysis
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Jonathan Burley
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Array printing
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Array printing using pin and piezo instruments
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Biophysics and Surface Analysis
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Morgan Alexander
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ToF-SIMS
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ToF-SIMS, including spatial mapping & depth profiling. X-ray photoelectron spectroscopy.
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Biophysics and Surface Analysis
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Morgan Alexander
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X-ray photoelectron spectroscopy
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ToF-SIMS, including spatial mapping & depth profiling. X-ray photoelectron spectroscopy.
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Biophysics and Surface Analysis
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Morgan Alexander
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Scanning Electron Microscope/Cryo-SEM
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Comprehensive Scanning Electron Microscope (SEM) facility/service. There is also Cryo-SEM available for freeze fracturing wet samples.
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Drug Delivery and Tissue Engineering
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Christine Grainger-Boultby
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Microparticle synthesis
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Micro & Nanoparticle synthesis and particle size analysis - including dynamic light scattering, laser particle sizing, zetapotential, disc centrifuge, Nanosight
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Drug Delivery and tissue engineering
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Snow Stolnik , Clive Roberts
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Microparticle sizing and characterisation
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Micro & Nanoparticle synthesis and particle size analysis - including dynamic light scattering, laser particle sizing, zetapotential, disc centrifuge, Nanosight
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Drug Delivery and tissue engineering
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Snow Stolnik , Clive Roberts
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Nanoparticle synthesis
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Micro & Nanoparticle synthesis and particle size analysis - including dynamic light scattering, laser particle sizing, zetapotential, disc centrifuge, Nanosight
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Drug Delivery and tissue engineering
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Snow Stolnik , Clive Roberts
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Nanoparticle sizing and characterisation
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Micro & Nanoparticle synthesis and particle size analysis - including dynamic light scattering, laser particle sizing, zetapotential, disc centrifuge, Nanosight
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Drug Delivery and tissue engineering
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Snow Stolnik , Clive Roberts
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Nanoscale drug delivery systems
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Nanoscale and colloidal drug delivery systems
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Drug Delivery and tissue engineering
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Martin Garnett
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Colloidal delivery systems
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Nanoscale and colloidal drug delivery systems
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Drug Delivery and tissue engineering
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Cynthia Bosquillon
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Protein formulation
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Small molecule, protein and nucleic acid formulation including controlled release and extended half-life
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Drug Delivery and tissue engineering
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Martin Garnett
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Nucleic acid formulation
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Small molecule, protein and nucleic acid formulation including controlled release and extended half-life
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Drug Delivery and tissue engineering
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Martin Garnett
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Controlled release formulations
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Small molecule, protein and nucleic acid formulation including controlled release and extended half-life
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Drug Delivery and tissue engineering
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Colin Melia
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Oral drug delivery
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Oral, mucosal and pulmonary drug delivery
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Drug Delivery and tissue engineering
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Colin Melia
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Mucosal Drug Delivery
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Oral, mucosal and pulmonary drug delivery
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Drug Delivery and tissue engineering
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Snow Stolnik
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Pulmonary drug delivery
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Oral, mucosal and pulmonary drug delivery
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Drug Delivery and tissue engineering
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Cynthia Bosquillon
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Lung absorption models
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In vitro drug permeability studies, models of lung epithelia
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Drug Delivery and tissue engineering
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Snow Stolnik
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In vitro drug permeability studies
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In vitro drug permeability studies, models of lung epithelia
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Drug Delivery and tissue engineering
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Snow Stolnik
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Isolated perfused rat lungs
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Isolated perfused rat lungs
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Drug Delivery and tissue engineering
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Cynthia Bosquillon
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Drug transporters in the lung
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Drug transporters in the lung
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Drug Delivery and tissue engineering
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Cynthia Bosquillon
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Cell delivery systems
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Cellular and mitochondrial delivery vectors
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Drug Delivery and tissue engineering
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Cameron Alexander
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Stimuli-responsive polymers
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Stimuli-responsive polymers
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Drug Delivery and tissue engineering
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Cameron Alexander
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Polymer synthesis
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Polymer design and biomaterials synthesis
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Drug Delivery and tissue engineering
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Cameron Alexander
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Biomaterials synthesis
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Polymer design and biomaterials synthesis
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Drug Delivery and tissue engineering
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Kevin Shakesheff
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Scaffolds for regenerative medicine
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Scaffolds for regenerative medicine
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Drug Delivery and tissue engineering
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Kevin Shakesheff
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Stem cell science
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Stem cell science including adult and embryonic stem cells
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Drug Delivery and tissue engineering
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Lee Buttery
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Fluorescence spectroscopy
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Light microscopy including epifluorescence and confocal. Fluorescence spectroscopy.
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Drug Delivery and tissue engineering
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Felicity Rose
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3D imaging of solids
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Microcomputed tomography for 3D imaging of solids and porous materials
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Drug Delivery and tissue engineering
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Kevin Shakesheff
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Microcomputed tomography
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Microcomputed tomography for 3D imaging of solids and porous materials
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Drug Delivery and tissue engineering
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Kevin Shakesheff
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Thermal properties of polymers
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Thermal and mechanical properties of polymers
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Drug Delivery and tissue engineering
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Kevin Shakesheff
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Mechanical Properties of polymers
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Thermal and mechanical properties of polymers
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Drug Delivery and tissue engineering
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Kevin Shakesheff
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Materials characterisation
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Materials characterisation (NMR, size exclusion chromatography)
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Drug Delivery and tissue engineering
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Cameron Alexander
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Supercritical fluid technologies
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Supercritical fluid technologies
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Drug Delivery and tissue engineering
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Kevin Shakesheff
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In vitro models
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In vitro models of bone, liver and other tissues
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Drug Delivery and tissue engineering
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Lee Buttery
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Stimuli-responsive polymers
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Stimuli-responsive polymers
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Drug Delivery and tissue engineering
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Cameron Alexander, Giuseppe Mantovani
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Polymer synthesis
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Polymer design and biomaterials synthesis
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Drug Delivery and tissue engineering
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Cameron Alexander, Giuseppe Mantovani
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Materials characterisation
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Materials characterisation (NMR, size exclusion chromatography)
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Drug Delivery and tissue engineering
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Cameron Alexander, Giuseppe Mantovani
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Glycomaterials synthesis
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Glycopolymers design and protein glycoconjugates synthesis
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Drug Delivery and tissue engineering
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Giuseppe Mantovani
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Protein-polymer biohybrid materials
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Site-specific protein conjugation
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Drug Delivery and tissue engineering
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Giuseppe Mantovani
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LC-MS
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We offer LC-MS analysis (qualitative or qualitative) of low (<1200) biological molecules using electrospray or APCI ionisation modes with either accurate mass/high resolution, MSn or targeted (MRM) MS detection
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Molecular and Cellular Science (MCS)
Centre of Analytical Bioscience (CAB)
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Dave Barrett
Catharine Ortori
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Transcription factors
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Transcription factors – nuclear receptors, p53, AML1, IRFs.
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Molecular and Cellular Science
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David Heery
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Transcription cofactors.
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Transcription cofactors.
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Molecular and Cellular Science
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David Heery
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Proteomics and enzymology
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Proteomics and enzymology
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Molecular and Cellular Science
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David Pritchard
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Post-translational modifications – SUMOylation.
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Post-translational modifications – SUMOylation. SUMOylation assays.
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Molecular and Cellular Science
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David Heery
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Chromatin modification
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Chromatin modification
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Molecular and Cellular Science
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David Heery
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Histone acetyltransferases
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Histone acetyltransferases. HAT assays and chemical inhibitor screens.
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Molecular and Cellular Science
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David Heery
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Immunology
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Immunology
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Molecular and Cellular Science
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David Pritchard
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Allergology
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Allergology
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Molecular and Cellular Science
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David Pritchard
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Parasites as therapy
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Parasite culture and clinical trial support
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Molecular and Cellular Science
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David Pritchard
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cDNA library construction
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Yeast two hybrid. Protein expression, purification and analysis. cDNA library construction.
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Molecular and Cellular Science
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David Pritchard
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Protein expression
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Yeast two hybrid. Protein expression, purification and analysis. cDNA library construction.
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Molecular and Cellular Science
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David Pritchard
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Protein Purification
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Yeast two hybrid. Protein expression, purification and analysis. cDNA library construction.
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Molecular and Cellular Science
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David Pritchard
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Protein Analysis
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Yeast two hybrid. Protein expression, purification and analysis. cDNA library construction.
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Molecular and Cellular Science
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David Pritchard
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Flow Cytometry
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Flow cytometry/FACS analysis
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Molecular and Cellular Science
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David Pritchard
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Stem cell transformation assays
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Haematopoietic stem cell transformation assays
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Molecular and Cellular Science
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Lee Buttery
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Immune cell culture
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Complex immune cell separation and culture (Treg, dendritic cells)
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Molecular and Cellular Science
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David Pritchard
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Immune cell separation
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Complex immune cell separation and culture (Treg, dendritic cells)
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Molecular and Cellular Science
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David Pritchard
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Allergy models
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Wound healing and allergy models
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Molecular and Cellular Science
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David Pritchard
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Wound healing models
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Wound healing and allergy models
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Molecular and Cellular Science
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David Pritchard
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Antibody assays
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Antibody & cytokine/chemokine assays
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Molecular and Cellular Science
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David Pritchard
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Cytokine/chemokine assays
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Antibody & cytokine/chemokine assays
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Molecular and Cellular Science
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David Pritchard
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Health Economics
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Health Economics
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Social Research in Medicines and Health
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Rachel Elliott
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Pharmacoepidemiology
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Pharmacoepidemiology
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Social Research in Medicines and Health
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Rachel Elliott
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E-Health
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E-Health
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Social Research in Medicines and Health
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Claire Anderson
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Role of the pharmacist
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Role of the pharmacist in improving the health of the public
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Social Research in Medicines and Health
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Claire Anderson
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Non-medical prescribing
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Non-medical prescribing
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Social Research in Medicines and Health
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Claire Anderson
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Pharmacy law and ethics
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Pharmacy law and ethics
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Social Research in Medicines and Health
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Claire Anderson
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Medicines adherence
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Medicines adherence
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Social Research in Medicines and Health
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Claire Anderson
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Pharmacy education
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Pharmacy education
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Social Research in Medicines and Health
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Claire Anderson
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Medicines use and safety
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Medicines use and safety
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Social Research in Medicines and Health
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Claire Anderson
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Qualitative Research
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Qualitative research (in-depth interviews & focus groups, observation, case studies)
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Social Research in Medicines and Health
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Claire Anderson
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Systematic literature reviews
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Systematic literature reviews
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Social Research in Medicines and Health
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Claire Anderson
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Health technology assessment
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Health technology assessment
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Social Research in Medicines and Health
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Rachel Elliott
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Health economic modelling
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Health economic modelling
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Social Research in Medicines and Health
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Rachel Elliott
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Primary care database manipulation
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Primary care database manipulation
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Social Research in Medicines and Health
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Matt Boyd
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Survey design and analysis
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Survey design and analysis
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Social Research in Medicines and Health
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Claire Anderson
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