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Y. pseudotuberculosis is a human enteropathogen with a biphasic lifestyle alternating between the food/water environment and the mammalian gastrointestinal tract. Infections usually arise via the faecal-oral route with enterocolitis presenting as fever, diarrhoea and abdominal pain lasting from 1-3 weeks. The virulence determinants of Y. pseudotuberculosis are known to be regulated by temperature and include invasins, adhesins and mechanisms for the evasion of host cell defences through the production of several Yop delivery and effector proteins. In Y. pseudotuberculosis we have shown that swimming motility and biofilm formation are regulated by temperature dependent quorum sensing systems consisting of at least two loci, ypsR/I and ytbR/I which synthesise and transduce at least 8 AHL signal molecules at biologically relevent concentrations.
Our current research is focussed on determining how the quorum sensing systems in all three pathogenic species of Yersinia are integrated into the temperature dependent regulation of motility, biofilm formation and type three secretion.
If you require more detailed information please go to QS in Y. pseudotuberculosis.
