I obtained my bachelor in Veterinary Medicine and Master in laboratory diagnosis from Qassim University in Saudi Arabia. I am currently a PhD student in immunology and pharmacology at the University of Nottingham and my funding for this degree comes from King Abdulaziz City for Science & Technology (KACST). I am a member of the Biochemical Society in the United Kingdom
Supervisors: Dr Franco H. Falcone (90%), Dr Cornelia de Moor (10%)
Schistosomiasis is one of the most dangerous parasitic diseases. The main species of this disease that infect humans are Schistosoma mansoni (S. mansoni), S. haematobium and S. japonicum. IPSE/alpha-1 is a glycoprotein secreted specifically by the egg stage of S. mansoni (Schramm et al. Mol Biochem Parasitol. 2006, 147: 9-19). Recent work has indicated that IPSE/alpha-1 is a potential hepatotoxin, leading to liver damage in infected hosts (Abdulla et al. PLoS Negl Trop Dis. 2011 Oct; 5(10):e1368).
My research focusses on understanding the potential role of IPSE/alpha-1 in host cell nuclei (transcription factor?), its relationship to hepatotoxicity, and whether other parasite-derived factors have the ability to translocate to host cell nuclei (Kaur et al. Infect Immun. 2011 Apr;79(4):1779-88).
Working with this project requires expertise in various techniques including molecular biology, recombinant protein expression purification, mammalian cell culture, microscopy and biochemistry