Allergy and Infectious Diseases
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AbdulazizAlouffi

Abdulaziz Alouffi

 

E-mail: paxaa17@nottingham.ac.uk

Background

I obtained my bachelor in Veterinary Medicine and Master in laboratory diagnosis from Qassim University in Saudi Arabia. I am currently a PhD student in immunology and pharmacology at the University of Nottingham and my funding for this degree comes from King Abdulaziz City for Science & Technology (KACST). I am a member of the Biochemical Society in the United Kingdom

Current Project

Supervisors: Dr Franco H. Falcone (90%), Dr Cornelia de Moor (10%)

Schistosomiasis is one of the most dangerous parasitic diseases. The main species of this disease that infect humans are Schistosoma mansoni (S. mansoni), S. haematobium and S. japonicum. IPSE/alpha-1 is a glycoprotein secreted specifically by the egg stage of S. mansoni (Schramm et al. Mol Biochem Parasitol. 2006, 147: 9-19). Recent work has indicated that IPSE/alpha-1 is a potential hepatotoxin, leading to liver damage in infected hosts (Abdulla et al. PLoS Negl Trop Dis. 2011 Oct; 5(10):e1368).

My research focusses on understanding the potential role of IPSE/alpha-1 in host cell nuclei (transcription factor?), its relationship to hepatotoxicity, and whether other parasite-derived factors have the ability to translocate to host cell nuclei (Kaur et al. Infect Immun. 2011 Apr;79(4):1779-88).

Working with this project requires expertise in various techniques including molecular biology, recombinant protein expression purification, mammalian cell culture, microscopy and biochemistry

 

Allergy and Infectious Diseases

The University of Nottingham
University Park
Nottingham, NG7 2RD


telephone:+44(0) 115 84 66073
email:franco.falcone@nottingham.ac.uk