Mat Daniel combines his clinical career in Ear, Nose, and Throat (ENT) surgery with research into Otitis Media with Effusion (OME).
Following undergraduate study at The University of Birmingham, Mat trained in ENT in the East Midlands, and completed a fellowship in Paediatric Otorhinolaryngology in Sydney. He is a Fellow of the Royal Colleges of Surgeons of England and Edinburgh, holds postgraduate qualifications in Management and Medical Education, and is a Fellow of the Higher Education Academy. He has completed a PhD at The University of Nottingham, entitled "Otitis media with effusion: Current treatment, new understanding of its aetiopathogenesis and a novel therapeutic approach".
In addition to peer-reviewed publications and presentations, his research has won multiple prizes, including those awarded by the Royal Society of Medicine, Otorhinolaryngologic Research Society, British Association for Paediatric Otorhinolaryngology, and American Society of Pediatric Otolaryngology.
He works for the NIHR Nottingham Hearing Biomedical Research Unit, Nottingham University Hospitals, and Sherwood Forest Hospitals.
Mat's main research interests have focused on the role of bacteria and biofilms in OME, and the treatment of biofilms with antibiotics. Biofilms are groups of bacteria living together surrounded by slime and attached to a surface. They are present in the middle ear of children with OME, and they are known to be difficult to kill with antibiotics. His current work is therefore investigating novel approaches to eradicate biofilms, by using antibiotic pellets that would release antibiotics over a period of several weeks t the site of infection, and then disintegrate of their own accord once they are no longer needed. This research is an interdisciplinary collaboration between the NIHR Nottingham Hearing BRU, Nottingham University's Otology and Hearing Research group (with Professor Birchall), Biomaterials-Related Infection Group (Dr Bayston), and the School of Pharmacy (Professor Shakesheff). Mat has also studied outcomes of grommet surgery and adenoidectomy as part of the TARGET ('Trial of Alternative Regimens in Glue Ear Treatment') trial for OME, investigated the effect that NICE guidelines on OME management have had on clinical practice, and collaborated with the Study of Environment on Aboriginal Resilience and Childhood Health.
Mat uses his clinical knowledge, combined with research experience, to undertake both basic science and clinical research, with the primary aims of translating laboratory work into direct patient benefit.
DANIEL M, KAMANI T, EL-SHUNNAR S, JABEROO M, HARRISON A, YALAMANCHILI S, HARRISON L, CHO W, FERGIE N, BAYSTON R and BIRCHALL JP, 2013. National Institute for Clinical Excellence guidelines on the surgical management of otitis media with effusion: are they being followed and have they changed practice? International journal of pediatric otorhinolaryngology. 77(1), 54-8 VENETTACCI O, NETTLEFOLD C, CHAN L, DANIEL M and CUROTTA J, 2013. Sub-labial packing: A novel method of stopping epistaxis from Little's area. International journal of pediatric otorhinolaryngology. 77(8), 1370-1 DANIEL M, CHESSMAN R, AL-ZAHID S, RICHARDS B, RAHMAN C, ASHRAF W, MCLAREN J, COX H, QUTACHI O, FORTNUM H, FERGIE N, SHAKESHEFF K, BIRCHALL JP and BAYSTON RR, 2012. Biofilm eradication with biodegradable modified-release antibiotic pellets: a potential treatment for glue ear. Archives of otolaryngology--head & neck surgery. 138(10), 942-9
DANIEL M, MCARDLE B, OSLAND K and CHENG ATL, 2012. Vocal cord reconstruction to treat aspiration caused by a post-intubation posterior glottic furrow. International journal of pediatric otorhinolaryngology. 76(11), 1688-90