Ying Zhang

Contact

• workRoom B11 Biodiscovery Institute
  University Park
  Nottingham
  NG7 2RD
  UK
• work0115 7486119
• ying.zhang@nottingham.ac.uk

Research Summary

Dr Ying Zhang is a molecular microbiologist with strong interests in engineering biology. Her training in PhD and first postdoctoral experience focused on protein manipulation, characterisation and… read more

Recent Publications

• GROSSE-HONEBRINK A, LITTLE GT, BEAN Z, HELDT D, CORNOCK RH, WINZER K, MINTON NP, GREEN E AND ZHANG Y, 2021. Development of Clostridium saccharoperbutylacetonicum as a whole cell biocatalyst for production of chirally pure (R)-1,3-butanediol. Frontiers in Bioengineering and Biotechnology. 9, 659895
• RUMAH, BASHIR L., STEAD, CHRISTOPHER E., CLAXTON STEVENS, BENEDICT H., MINTON, NIGEL P., GROSSE-HONEBRINK, ALEXANDER and ZHANG, YING, 2021. Isolation and characterisation of Methylocystis spp. for poly-3-hydroxybutyrate production using waste methane feedstocks AMB EXPRESS. 11(1),
• LAU, MATTHEW S. H., SHENG, LILI, ZHANG, YING and MINTON, NIGEL P., 2021. Development of a Suite of Tools for Genome Editing in Parageobacillus thermoglucosidasius and Their Use to Identify the Potential of a Native Plasmid in the Generation of Stable Engineered Strains ACS SYNTHETIC BIOLOGY. 10(7), 1739-1749
• BASHIR, ZEENAT, SHENG, LILI, ANIL, ANNAMMA, LALI, ARVIND, MINTON, NIGEL P. and ZHANG, YING, 2019. Engineering Geobacillus thermoglucosidasius for direct utilisation of holocellulose from wheat straw BIOTECHNOLOGY FOR BIOFUELS. 12(1),

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Current Research

Dr Ying Zhang is a molecular microbiologist with strong interests in engineering biology. Her training in PhD and first postdoctoral experience focused on protein manipulation, characterisation and engineering with Prof Richard James at the University of Nottingham in the School of Molecular Medical Sciences. After moving to Clostridia Research Group (CRG), now the BBSRC/EPSRC Synthetic Biology Research Centre (SBRC), she has been working with several commercially valuable bacteria, using novel genetic engineering tools to generate novel strains with advanced properties such as enhanced products yield and selectivity. She is an early career researcher in synthetic biology, and her current research focuses on combining protein engineering and metabolic engineering, using biological engineering tools and synthetic biology approaches to design/redesign pathways, biological components and devices for production of both medically and industrially important commodities.

• GROSSE-HONEBRINK A, LITTLE GT, BEAN Z, HELDT D, CORNOCK RH, WINZER K, MINTON NP, GREEN E AND ZHANG Y, 2021. Development of Clostridium saccharoperbutylacetonicum as a whole cell biocatalyst for production of chirally pure (R)-1,3-butanediol. Frontiers in Bioengineering and Biotechnology. 9, 659895
• RUMAH, BASHIR L., STEAD, CHRISTOPHER E., CLAXTON STEVENS, BENEDICT H., MINTON, NIGEL P., GROSSE-HONEBRINK, ALEXANDER and ZHANG, YING, 2021. Isolation and characterisation of Methylocystis spp. for poly-3-hydroxybutyrate production using waste methane feedstocks AMB EXPRESS. 11(1),
• LAU, MATTHEW S. H., SHENG, LILI, ZHANG, YING and MINTON, NIGEL P., 2021. Development of a Suite of Tools for Genome Editing in Parageobacillus thermoglucosidasius and Their Use to Identify the Potential of a Native Plasmid in the Generation of Stable Engineered Strains ACS SYNTHETIC BIOLOGY. 10(7), 1739-1749
• BASHIR, ZEENAT, SHENG, LILI, ANIL, ANNAMMA, LALI, ARVIND, MINTON, NIGEL P. and ZHANG, YING, 2019. Engineering Geobacillus thermoglucosidasius for direct utilisation of holocellulose from wheat straw BIOTECHNOLOGY FOR BIOFUELS. 12(1),
• SCHWARZ KM, GROSSE-HONEBRINK A, DERECKA K, ROTTA C, ZHANG Y and MINTON NP, 2017. Towards improved butanol production through targeted genetic modification of Clostridium pasteurianum. Metabolic engineering. 40, 124-137
• SHENG L, KOVÁCS K, WINZER K, ZHANG Y and MINTON NP, 2017. Development and implementation of rapid metabolic engineering tools for chemical and fuel production in Geobacillus thermoglucosidasius NCIMB 11955. Biotechnology for Biofuels. 10, 5
• GROSSE-HONEBRINK A, SCHWARZ KM, WANG H, MINTON NP and ZHANG Y, 2017. Improving gene transfer in Clostridium pasteurianum through the isolation of rare hypertransformable variants. Anaerobe. (In Press.)
• MINTON NP, EHSAAN M, HUMPHREYS CM, LITTLE GT, BAKER J, HENSTRA AM, LIEW F, KELLY ML, SHENG L and SCHWARZ K, 2016. A roadmap for gene system development in Clostridium. Anaerobe. 41, 104-112.
• LI Q, CHEN J, MINTON NP, ZHANG Y, WEN Z, LIU J, YANG H, ZENG Z, REN X, YANG J, GU Y, JIANG W, JIANG Y and YANG S, 2016. CRISPR-based genome editing and expression control systems in Clostridium acetobutylicum and Clostridium beijerinckii. Biotechnology Journal. 11(7), 961-72
• ZHANG Y, XU S, CHAI C, YANG S, JIANG W, MINTON NP and GU Y, 2016. Development of an inducible transposon system for efficient random mutagenesis in Clostridium acetobutylicum. FEMS microbiology letters. 363(8),
• EHSAAN M, KUIT W, ZHANG Y, CARTMAN ST, HEAP JT, WINZER K and MINTON NP, 2016. Mutant generation by allelic exchange and genome resequencing of the biobutanol organism Clostridium acetobutylicum ATCC 824. Biotechnology for Biofuels. 9, 4
• SHENG L, ZHANG Y and MINTON NP, 2016. Complete Genome Sequence of Geobacillus thermoglucosidasius NCIMB 11955, the Progenitor of a Bioethanol Production Strain. Genome announcements. 4(5),
• WEN Z, MINTON NP, ZHANG Y, LI Q, LIU J, JIANG Y and YANG S, 2016. Enhanced solvent production by metabolic engineering of a twin-clostridial consortium. Metabolic engineering. 39, 38-48
• ZHANG Y, GROSSE-HONEBRINK A and MINTON NP, 2015. A universal mariner transposon system for forward genetic studies in the genus Clostridium. PloS one. 10(4), e0122411
• POEHLEIN A, GROSSE-HONEBRINK A, ZHANG Y, MINTON NP and DANIEL R, 2015. Complete Genome Sequence of the Nitrogen-Fixing and Solvent-Producing Clostridium pasteurianum DSM 525. Genome announcements. 3(1),
• LI, C., ZHANG, Y., VANKEMMELBEKE, M., HECHT, O., ALEANIZY, F.S., MACDONALD, C., MOORE, G.R., JAMES, R. and PENFOLD, C.N., 2012. Structural evidence that colicin A protein binds to a novel binding site of TolA protein in Escherichia coli periplasm Journal of Biological Chemistry. 287(23), 19048-19057
• COOKSLEY, C.M., ZHANG, Y., WANG, H., REDL, S., WINZER, K. and MINTON, N.P., 2012. Targeted mutagenesis of the Clostridium acetobutylicum acetone-butanol-ethanol fermentation pathway Metabolic Engineering. 14(6), 630-641
• PENFOLD, C.N., LI, C., ZHANG, Y., VANKEMMELBEKE, M. and JAMES, R., 2012. Colicin A binds to a novel binding site of TolA in the Escherichia coli periplasm Biochemical Society Transactions. 40(6), 1469-1474
• ZHANG, YING, LI, CHAN, VANKEMMELBEKE, MIREILLE N., BARDELANG, PHILIP, PAOLI, MAX, PENFOLD, CHRISTOPHER N. and JAMES, RICHARD, 2010. The crystal structure of the TolB box of colicin A in complex with TolB reveals important differences in the recruitment of the common TolB translocation portal used by group A colicins MOLECULAR MICROBIOLOGY. 75(3), 623-636
• HECHT, OLIVER, ZHANG, YING, LI, CHAN, PENFOLD, CHRISTOPHER N., JAMES, RICHARD and MOORE, GEOFFREY R., 2010. Characterisation of the interaction of colicin A with its co-receptor TolA FEBS LETTERS. 584(11), 2249-2252
• BARDELANG, PHILIP, VANKEMMELBEKE, MIREILLE, ZHANG, YING, JARVIS, HANNAH, ANTONIADOU, ELENI, ROCHETTE, SOPHIE, THOMAS, NEIL R., PENFOLD, CHRISTOPHER N. and JAMES, RICHARD, 2009. Design of a polypeptide FRET substrate that facilitates study of the antimicrobial protease lysostaphin BIOCHEMICAL JOURNAL. 418, 615-624
• VANKEMMELBEKE, MIREILLE, ZHANG, YING, MOORE, GEOFFREY R., KLEANTHOUS, COLIN, PENFOLD, CHRISTOPHER N. and JAMES, RICHARD, 2009. Energy-dependent Immunity Protein Release during tol-dependent Nuclease Colicin Translocation JOURNAL OF BIOLOGICAL CHEMISTRY. 284(28), 18932-18941
• ZHANG, YING, VANKEMMELBEKE, MIREILLE N., HOLLAND, LISA E., WALKER, DAVID C., JAMES, RICHARD and PENFOLD, CHRISTOPHER N., 2008. Investigating early events in receptor binding and translocation of colicin E9 using synchronized cell killing and proteolytic cleavage JOURNAL OF BACTERIOLOGY. 190(12), 4342-4350