Helen Budge

Contact

• workRoom Academic Child Health University Hospital
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 823 1090
• helen.budge@nottingham.ac.uk

Biography

Helen is Professor of Neonatal Medicine at the University and Honorary Consultant Neonatologist for Nottingham University Hospitals NHS Trust.

She graduated in Physiological Sciences and in Medicine from the University of Oxford Medical School and trained in Paediatrics & Neonatology in Oxford and Nottingham. She was awarded her PhD from the University of Nottingham in 2003.

She was appointed as Director of the Academic Unit of Population and Lifespan Sciences in 2021 and is also Director of Nottingham's Clinical Academic Training Programme. She has previously served as Head of the former Division of Child Health, Obstetrics & Gynaecology, as Director of Infrastructure & Personnel and as Deputy Head of School.

Research Summary

Current Research Profile includes:

• The role of brown adipose tissue in energy expenditure
• Long-term sequelae of perinatal influences
• Maternal and neonatal influences on health and disease
• Control of growth and development
• Fetal and Neonatal Nutrition
• Neonatology

Recent Publications

• LAW, JAMES M, MORRIS, DAVID E, ROBINSON, LINDSAY, RANDELL, TABITHA, DENVIR, LOUISE, SYMONDS, MICHAEL E and BUDGE, HELEN, 2020. Reduced Brown Adipose Tissue‐Associated Skin Temperature Following Cold Stimulation in Children and Adolescents with Type 1 Diabetes Pediatric Diabetes.
• ALDISS P, SYMONDS ME, LEWIS JE, BOOCOCK DJ, MILES AK, BLOOR I, EBLING FJP and BUDGE H, 2019. Interscapular and Perivascular Brown Adipose Tissue Respond Differently to a Short-Term High-Fat Diet. Nutrients. 11(5), pii: E1065.
• RETZLER, JENNY, JOHNSON, SAMANTHA, GROOM, MADELEINE, HOLLIS, CHRIS, BUDGE, HELEN and CRAGG, LUCY, 2019. Cognitive predictors of parent-rated inattention in very preterm children: The role of working memory and processing speed CHILD NEUROPSYCHOLOGY. 25(5), 617-635
• VELICKOVIC, KSENIJA, WAYNE, DECLAN, LEIJA, HILDA ANAID LUGO, BLOOR, IAN, MORRIS, DAVID E, LAW, JAMES, BUDGE, HELEN, SACKS, HAROLD, SYMONDS, MICHAEL E and SOTTILE, VIRGINIE, 2019. Caffeine exposure induces browning features in adipose tissue in vitro and in vivo Scientific Reports. 9(1), 9104

• View all publications

• LAW, JAMES M, MORRIS, DAVID E, ROBINSON, LINDSAY, RANDELL, TABITHA, DENVIR, LOUISE, SYMONDS, MICHAEL E and BUDGE, HELEN, 2020. Reduced Brown Adipose Tissue‐Associated Skin Temperature Following Cold Stimulation in Children and Adolescents with Type 1 Diabetes Pediatric Diabetes.
• ALDISS P, SYMONDS ME, LEWIS JE, BOOCOCK DJ, MILES AK, BLOOR I, EBLING FJP and BUDGE H, 2019. Interscapular and Perivascular Brown Adipose Tissue Respond Differently to a Short-Term High-Fat Diet. Nutrients. 11(5), pii: E1065.
• RETZLER, JENNY, JOHNSON, SAMANTHA, GROOM, MADELEINE, HOLLIS, CHRIS, BUDGE, HELEN and CRAGG, LUCY, 2019. Cognitive predictors of parent-rated inattention in very preterm children: The role of working memory and processing speed CHILD NEUROPSYCHOLOGY. 25(5), 617-635
• VELICKOVIC, KSENIJA, WAYNE, DECLAN, LEIJA, HILDA ANAID LUGO, BLOOR, IAN, MORRIS, DAVID E, LAW, JAMES, BUDGE, HELEN, SACKS, HAROLD, SYMONDS, MICHAEL E and SOTTILE, VIRGINIE, 2019. Caffeine exposure induces browning features in adipose tissue in vitro and in vivo Scientific Reports. 9(1), 9104
• LAW, JAMES, MORRIS, DAVID E, ROBINSON, LINDSAY;, RANDELL, TABITHA, DENVIR, LOUISE, SYMONDS, MICHAEL E and BUDGE, HELEN, 2019. Paediatric patients with type 1 diabetes mellitus exhibit reduced brown adipose tissue heat signature following cold stimulation HORMONE RESEARCH IN PAEDIATRICS. 91, 304
• LAW, JAMES M, MORRIS, DAVID E, ASTLE, VALERIE, FINN, ELLIE, MUROS, JOSÉ JOAQUÍN, ROBINSON, LINDSAY J, RANDELL, TABITHA, DENVIR, LOUISE, SYMONDS, MICHAEL E and BUDGE, HELEN, 2019. Brown adipose tissue response to cold stimulation is reduced in girls with autoimmune hypothyroidism Journal of the Endocrine Society. 3(12), 2411-2426
• ROBINSON, LJ, LAW, J, ASTLE, V, GUTIÉRREZ GARCÍA, M, OJHA, S, SYMONDS, ME, PITCHFORD, N and BUDGE, H, 2019. Sexual dimorphism of brown adipose tissue function Journal of Pediatrics. 2010, 166-172.e1
• ALDISS, P., BETTS, J., SALE, C., POPE, M., BUDGE, H. and SYMONDS, M.E., 2018. Exercise-induced ‘browning’ of adipose tissues Metabolism: Clinical and Experimental. 81, 63-70
• FAINBERG, HERNAN P., BIRTWISTLE, MARK, ALAGAL, REHAM, ALHADDAD, AHMAD, POPE, MARK, DAVIES, GRAEME, WOODS, RACHEL, CASTELLANOS, MARCOS, MAY, SEAN T., ORTORI, CATHARINE A., BARRETT, DAVID A., PERRY, VIV, WIENS, FRANK, STAHL, BERND, VAN DER BEEK, ELINE, SACKS, HAROLD, BUDGE, HELEN and SYMONDS, MICHAEL E., 2018. Transcriptional analysis of adipose tissue during development reveals depot-specific responsiveness to maternal dietary supplementation SCIENTIFIC REPORTS. 8((1)), 9328
• SYMONDS, MICHAEL E., ALDISS, PETER, DELLSCHAFT, NEELE, LAW, JAMES, FAINBERG, HERNAN P., POPE, MARK, SACKS, HAROLD and BUDGE, HELEN, 2018. Brown adipose tissue development and function and its impact on reproduction JOURNAL OF ENDOCRINOLOGY. 238(1), R53-R62
• LAW, JAMES, MORRIS, DAVID E., IZZI-ENGBEAYA, CHIOMA, SALEM, VICTORIA, COELLO, CHRISTOPHER, ROBINSON, LINDSAY, JAYASINGHE, MADUKA, SCOTT, REBECCA, GUNN, ROGER, RABINER, EUGENII, TAN, TRICIA, DHILLO, WALJIT S., BLOOM, STEPHEN, BUDGE, HELEN and SYMONDS, MICHAEL E., 2018. Thermal Imaging Is a Noninvasive Alternative to PET/CT for Measurement of Brown Adipose Tissue Activity in Humans JOURNAL OF NUCLEAR MEDICINE. 59(3), 516-522
• SAROHA, VIVEK, DELLSCHAFT, NEELE S., KEISLER, DUANE H., GARDNER, DAVID S., BUDGE, HELEN, SEBERT, SYLVAIN P. and SYMONDS, MICHAEL E., 2018. Tissue cell stress response to obesity and its interaction with late gestation diet REPRODUCTION FERTILITY AND DEVELOPMENT. 30(3), 430-441
• SCOTNEY, H., SYMONDS, M.E., LAW, J., BUDGE, H., SHARKEY, D. and MANOLOPOULOS, K.N., 2017. Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo Metabolism: Clinical and Experimental. 70, 125-132
• SYMONDS, M.E., BLOOR, I., OJHA, S. and BUDGE, H., 2017. The Placenta, Maternal Diet and Adipose Tissue Development in the Newborn Annals of Nutrition and Metabolism. 70, 232-235
• ALDISS, P., DAVIES, G., WOODS, R., BUDGE, H., SACKS, H.S. and SYMONDS, M.E., 2017. ‘Browning’ the cardiac and peri-vascular adipose tissues to modulate cardiovascular risk International Journal of Cardiology. 228, 265-274
• HENRY, B.A., POPE, M., BIRTWISTLE, M., LOUGHNAN, R., ALAGAL, R., FULLER-JACKSON, J.-P., PERRY, V., BUDGE, H., CLARKE, I.J. and SYMONDS, M.E., 2017. Ontogeny and thermogenic role for sternal fat in female sheep Endocrinology. 158(7), 2212-2225
• OJHA, S., SAND, L., RATNAVEL, N., KEMPLEY, S.T., SINHA, A.K., MOHINUDDIN, S., BUDGE, H. and LESLIE, A., 2017. Newborn infants with bilious vomiting: A national audit of neonatal transport services Archives of Disease in Childhood: Fetal and Neonatal Edition. 102(6), F515-F518
• ALDISS, P., DELLSCHAFT, N., SACKS, H., BUDGE, H. and SYMONDS, M.E., 2017. Beyond obesity - thermogenic adipocytes and cardiometabolic health Hormone Molecular Biology and Clinical Investigation. 31(2),
• ROBINSON, L.J., LAW, J.M., SYMONDS, M.E. and BUDGE, H., 2016. Brown adipose tissue activation as measured by infrared thermography by mild anticipatory psychological stress in lean healthy females Experimental Physiology. 101(4), 549-557
• MARTINO, J., SEBERT, S., SEGURA, M.T., GARCIA-VALDÉS, L., FLORIDO, J., PADILLA, M.C., MARCOS, A., RUEDA, R., MCARDLE, H.J., BUDGE, H., SYMONDS, M.E. and CAMPOY, C., 2016. Maternal body weight and gestational diabetes differentially influence placental and pregnancy outcomes Journal of Clinical Endocrinology and Metabolism. 101(1), 59-68
• SALEM, V., IZZI-ENGBEAYA, C., COELLO, C., THOMAS, D.B., CHAMBERS, E.S., COMNINOS, A.N., BUCKLEY, A., WIN, Z., AL-NAHHAS, A., RABINER, E.A., GUNN, R.N., BUDGE, H., SYMONDS, M.E., BLOOM, S.R., TAN, T.M. and DHILLO, W.S., 2016. Glucagon increases energy expenditure independently of brown adipose tissue activation in humans Diabetes, Obesity and Metabolism. 18(1), 72-81
• SHALINI OJHA, HERNAN P FAINBERG, VICTORIA WILSON, GUISEPPE PELELLA, MARCUS CASTELLANOS, SEAN T MAY, ATTILIO A LOTTO, HAROLD SACKS, MICHAEL E SYMONDS and HELEN BUDGE, 2016. Gene pathway development in human epicardial adipose tissue during early life JCI Insight. 1(13), e87460
• ALDISS, P., BUDGE, H. and SYMONDS, M.E., 2016. Is a reduction in brown adipose thermogenesis responsible for the change in core body temperature at menopause? Cardiovascular Endocrinology. 5(4), 155-156
• SYMONDS, M.E., DELLSCHAFT, N., POPE, M., BIRTWISTLE, M., ALAGAL, R., KEISLER, D. and BUDGE, H., 2016. Developmental programming, adiposity, and reproduction in ruminants Theriogenology. 86(1), 120-129
• SHALINI OJHA, MICHAEL E SYMONDS and HELEN BUDGE, 2015. Suboptimal maternal nutrition during early-to-mid gestation in the sheep enhances pericardial adiposity in the near term fetus Reproduction, Fertility and Development. 27, 1205-1212
• SYMONDS, M.E., POPE, M. and BUDGE, H., 2015. The Ontogeny of Brown Adipose Tissue Annual Review of Nutrition. 35(1), 295-320
• OJHA, S., FAINBERG, H.P., SEBERT, S., BUDGE, H. and SYMONDS, M.E., 2015. Maternal health and eating habits: Metabolic consequences and impact on child health Trends in Molecular Medicine. 21(2), 126-133
• DELLSCHAFT, N.S., ALEXANDRE-GOUABAU, M.-C., GARDNER, D.S., ANTIGNAC, J.-P., KEISLER, D.H., BUDGE, H., SYMONDS, M.E. and SEBERT, S.P., 2015. Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring Journal of Endocrinology. 224(2), 171-182
• OJHA, S., SYMONDS, M.E. and BUDGE, H., 2015. Suboptimal maternal nutrition during early-to-mid gestation in the sheep enhances pericardial adiposity in the near-term fetus Reproduction, Fertility and Development. 27(8), 1205-1212
• POPE, M., BUDGE, H. and SYMONDS, M.E., 2014. The developmental transition of ovine adipose tissue through early life Acta Physiologica. 210(1), 20-30
• ROBINSON, L., OJHA, S., SYMONDS, M.E. and BUDGE, H., 2014. Body mass index as a determinant of brown adipose tissue function in healthy children Journal of Pediatrics. 164(2), 318-322.e1
• LAW, J., BLOOR, I., BUDGE, H. and SYMONDS, M.E., 2014. The influence of sex steroids on adipose tissue growth and function Hormone Molecular Biology and Clinical Investigation. 19(1), 13-24
• MODI, N., CLARK, H., WOLFE, I., COSTELLO, A. and BUDGE, H., 2013. A healthy nation: strengthening child health research in the UK Lancet. 381(9860), 73-87
• OJHA S, SAROHA V, SYMONDS ME and BUDGE H, 2013. Excess nutrient supply in early life and its later metabolic consequences. Clinical and Experimental Pharmacology & Physiology. 40(11), 817
• SHALINI OJHA, MARK BIRTWISTLE, HELEN BUDGE and MICHAEL E SYMONDS, 2013. Brown adipose tissue: a new human organ? Expert Reviews of Endocrinology and Metabolism. 8(2), 123-125
• SACKS HS, FAIN JN, BAHOUTH SW, OJHA S, FRONTINI A, BUDGE H, CINTI S and SYMONDS ME, 2013. Adult epicardial fat exhibits beige features. The Journal of clinical endocrinology and metabolism. 98(9), E1448-55
• BLOOR, I.D., SÉBERT, S.P., SAROHA, V., GARDNER, D.S., KEILSER, D.H., BUDGE, H., SYMONDS, M.E. and MAHAJAN, R.P., 2013. Sex differences in metabolic and adipose tissue responses to juvenile onset obesity in sheep Endocrinology. 154(10), 3622-3631
• OJHA S, ROBINSON L, YAZDANI M, SYMONDS ME and BUDGE H, 2013. Brown adipose tissue genes in pericardial adipose tissue of newborn sheep are downregulated by maternal nutrient restriction in late gestation. Pediatric research. 74(3), 246-51
• REGNAULT TRH, NIJLAND MJ, BUDGE H and MORRISON JL, 2013. Basic experimental and clinical advances in the mechanisms underlying abnormal pregnancy outcomes. Journal of pregnancy. 2013, 327638
• SYMONDS, M.E., POPE, M., SHARKEY, D. and BUDGE, H., 2012. Adipose tissue and fetal programming Diabetologia. 55(6), 1597-1606
• SYMONDS, M.E., HENDERSON, K., ELVIDGE, L., BOSMAN, C., SHARKEY, D., PERKINS, A.C. and BUDGE, H., 2012. Thermal imaging to assess age-related changes of skin temperature within the supraclavicular region co-locating with brown adipose tissue in healthy children Journal of Pediatrics. 161(5), 892-898
• MICHAEL E SYMONDS, MARK POPE and HELEN BUDGE, 2012. Session 1: Early nutrition programming, life performance and cognitive function Adipose tissue development during early life: novel insights into energy balance from small and large mammals: Metabolic flexibility in animal and human nutrition In: Oskar Kellner Symposium 2011. 1-7
• MICHAEL E SYMONDS and HELEN BUDGE, 2012. How promising is thermal imaging in the quest to combat obesity Imaging Med. 4(6), 589-591
• SEBERT, S.P., DELLSCHAFT, N.S., CHAN, L.L.Y., STREET, H., HENRY, M., FRANCOIS, C., SHARMA, V., FAINBERG, H.P., PATEL, N., RODA, J., KEISLER, D., BUDGE, H. and SYMONDS, M.E., 2011. Maternal nutrient restriction during late gestation and early postnatal growth in sheep differentially reset the control of energy metabolism in the gastric mucosa Endocrinology. 152(7), 2816-2826
• SYMONDS, MICHAEL E, BUDGE, HELEN, PERKINS, ALAN C and LOMAX, MICHAEL A, 2011. Adipose tissue development - Impact of the early life environment. Progress in Biophysics and Molecular Biology. 106(1), 300-6
• SEBERT, S., SHARKEY, D, BUDGE, H and SYMONDS, M.E., 2011. The early programming of metabolic health: is epigenetic setting the missing link? American Journal of Clinical Nutrition. 94(6), 1953S-1958S
• ATKINSON, M and BUDGE, H, 2011. Review Of The Nice Guidance On Neonatal Jaundice Archives Of Disease In Childhood-Education And Practice Edition. 96(4), 136-140
• FAINBERG HP, BUDGE H and SYMONDS ME, 2011. Proceedings of the Nutrition Society The conflicting effects of maternal nutrient restriction and early-life obesity on renal health. 70(2), 268-275
• HYATT, MA, GARDNER, DS, SEBERT, S, WILSON, V, DAVIDSON, N, NIGMATULLINA, Y, CHAN, LLY, BUDGE, H and SYMONDS, ME, 2011. Suboptimal Maternal Nutrition, During Early Fetal Liver Development, Promotes Lipid Accumulation In The Liver Of Obese Offspring Reproduction. 141(1), 119-126
• SYMONDS, MICHAEL E, SEBERT, SYLVAIN and BUDGE, HELEN, 2011. The obesity epidemic: from the environment to epigenetics - not simply a response to dietary manipulation in a thermoneutral environment: The obesity epidemic: more than increased fat intake Frontiers in Genetics: Epigenomics. 2(Article 24), 1-10