GI and Liver Diseases Medical and Surgical Research
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Tanya Monaghan

Clinical Associate Professor, Anne McLaren Fellow and Honorary Consultant in Gastroenterology, Faculty of Medicine & Health Sciences

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Biography

I came to Nottingham in 2006 and took up the position as the first NIHR Academic Clinical Fellow in Gastroenterology. Alongside clinical training, I worked in the laboratory of Professor Yash Mahida. I was subsequently awarded a Wellcome Trust Clinical Training Fellowship in 2009 to study the host immune response to C. difficile toxins A and B, the principal virulence factors involved in disease pathogenesis, and was awarded my PhD in 2013.

In 2013, I commenced an NIHR Academic Clinical Lectureship in Gastroenterology in the Nottingham Digestive Diseases Biomedical Research Unit. I was awarded an Academy of Medical Sciences Starter Grant for Clinical Lecturers to study novel antimicrobial treatments for C. difficile infection (CDI), utilising a human in vitro gut model of CDI developed by Professor Mark Wilcox, University of Leeds. In collaboration with the Immunology Department at UoN and with the help of a subsequent Hermes Fellowship, I have also adapted a protein microarray platform to investigate antigen-specific antibody responses in the circulation of patients with CDI. This assay is also being used a prediction tool and has recently received a UK patent.

I have established collaborations with Dr Nick Hannan, University of Nottingham to determine the utility of a human stem-cell derived intestinal organoid culture model in modelling Crohn's disease and studying C. difficile pathogenesis. We hope to use this model to develop and test new therapies for CDI and inflammatory bowel disease. I am also working closely with Dr Dina Kao at the University of Alberta to study immune mechanisms of action of faecal microbiota transplantation therapy for CDI.

In 2017, I was awarded an Anne McLaren Fellowship to study Clostridium difficile infection in urbanised and tribal communities in Central India. I plan to undertake molecular epidemiological and ethnopharmacological studies with the assistance of the Central India Institutes of Medical Sciences, Mahatma Gandhi Tribal Hospital, C. difficile Ribotyping Network and School of Pharmacy, University of Nottingham. I will also work closely with Bioinformatics experts and statisticians within the Advanced Data Analysis (ADAC).

Expertise Summary

C. difficile infection - adaptive immune responses to C. difficile toxins A and B in varied patient groups

  • Developmental ELISA and ELISPOT assays
  • Protein microarray assays
  • Antigen-specific flow cytometry
  • In vitro gut models of C. difficile infection

Medical Education publishing:

  • Oxford Handbook of Clinical Examination and Practical Skills. Thomas J, Monaghan T. Pub: Oxford University Press, Oxford. June 2007.
  • 2 ed. published July 2014.
  • "Highly commended" at BMA Medical Book Awards 2015
  • Oxford Handbooks Clinical Tutor Study Cards: Medicine. Monaghan T, Thomas J. Pub: Oxford University Press, Oxford. September 2011
  • Oxford Handbooks Clinical Study Cards: Surgery. Monaghan T, Thomas J, Humes D. Pub: Oxford University Press, Oxford. September 2011
  • Oxford Handbooks Clinical Study Cards: Practical Procedures. Thomas J, Monaghan T, Thompson A. Pub: Oxford University Press, Oxford. September 2011.

Research Summary

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Recent Publications

Current Research

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Studying the effects of alternative antimicrobial agents using an in vitro gut model which simulates C. difficile infection

Studying carriage of C. difficile and toxigenic C. difficile in different IBD populations

Development of a microarray assay to study antibody responses to C. difficile toxins

Future Research

Development of an human stem-cell derived intestinal organoid platform to study C. difficile pathogenesis

Nottingham Digestive Diseases Centre

The University of Nottingham
E Floor, West Block, Queen's Medical Centre
Nottingham, NG7 2UH


telephone: +44 (0) 115 82 31090
email:nddcbru@nottingham.ac.uk