Safety Office
   
   
  

Genetic Modification

Work involving the use or production of genetically modified organisms is regulated by the Genetically Modified Organisms (Contained Use) Regulations 2000.

The main requirements of the Regulations are that a risk assessment must be carried out for the work and that this is approved by a local Genetic Modification Safety Committee (GMSC).

Genetic modification in relation to an organism is defined as "the altering of the genetic material in that organism by a way that does not occur naturally by mating or a natural recombination or both".

University Guidance

The Safety Office has issued the following guidance documents to assist researches in compliance with the regulations:

  • Suppliers of commercially available genetically modified cell lines and those that have been immortalized by a GM technique are now requesting a signed declaration containing our GM Centre Registration Number and the name of the person within the lab/facility who is responsible for GMO supervision and safety. These declarations should be completed locally and will be sent every 5 years.
  • The University GM Center Number is GM 470.
  • The person responsible for GMO supervision and safety would be the Principal Investigator for the project
  • This has led to questions being raised about the requirement for a GM risk assessment in order to import, store and grow these cells. The GMSC has approved the use of the following generic assessment to cover the use of any such cells - it does not cover any further / subsequent modification of the cells which would need a full RA. The form should be signed by the PI to confirm control measures are in place and list the cell lines. The local BSO/Safety Officer should also countersign the form. The form should be retained alongside other approved GM risk assessments.

GM Forms

All GM forms can be found on the Safety Office Workspace.

 

Safety Office

Pharmacy Building - Lower Ground Floor
University Park
University of Nottingham
Nottingham, NG7 2RD

Telephone: +44 (0)115 951 3401
email: bb-safety-office@exmail.nottingham.ac.uk