Recent Publications
Kawabe, K., D. Lindsay, M. Braitch, A. J. Fahey, L. Showe and C. S. Constantinescu (2012). IL-12 inhibits glucocorticoid-induced T cell apoptosis by inducing GMEB1 and activating PI3K/Akt pathway. Immunobiology 217(1): 118-123.
Constantinescu, C. S., N. Farooqi, K. O'Brien and B. Gran (2011). Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS). Br J Pharmacol 164(4): 1079-1106.
Constantinescu, C. S., G. Niepel, M. Patterson, A. Judd, M. Braitch, A. J. Fahey, S. Harikrishnan, L. J. Edwards, C. R. Tench, G. W. Bennett and M. Ghatei (2011). Orexin A (hypocretin-1) levels are not reduced while cocaine/amphetamine regulated transcript levels are increased in the cerebrospinal fluid of patients with multiple sclerosis: no correlation with fatigue and sleepiness. J Neurol Sci 307(1-2): 127-131.
Downer, E. J., E. Clifford, B. Gran, H. J. Nel, P. G. Fallon and P. N. Moynagh (2011). Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 activation and IFN-beta expression: relevance to therapeutic effects in models of multiple sclerosis. J Biol Chem 286(12): 10316-10328.
Edwards, L. J., B. Sharrack, A. Ismail, H. Tumani and C. S. Constantinescu (2011). Central inflammation versus peripheral regulation in multiple sclerosis. J Neurol 258(8): 1518-1527.
Hart, B. A., B. Gran and R. Weissert (2011). EAE: imperfect but useful models of multiple sclerosis. Trends Mol Med 17(3): 119-125.
Jagessar, S. A., B. Gran, N. Heijmans, J. Bauer, J. D. Laman, B. A. t Hart and C. S. Constantinescu (2011). Discrepant Effects of Human Interferon-gamma on Clinical and Immunological Disease Parameters in a Novel Marmoset Model for Multiple Sclerosis. J Neuroimmune Pharmacol.
Mistry, N., E. C. Tallantyre, J. E. Dixon, N. Galazis, T. Jaspan, P. S. Morgan, P. Morris and N. Evangelou (2011). Focal multiple sclerosis lesions abound in 'normal appearing white matter'. Mult Scler 17(11): 1313-1323.
Nyirenda, M. H., L. Sanvito, P. J. Darlington, K. O'Brien, G. X. Zhang, C. S. Constantinescu, A. Bar-Or and B. Gran (2011). TLR2 stimulation drives human naive and effector regulatory T cells into a Th17-like phenotype with reduced suppressive function. J Immunol 187(5): 2278-2290.
Sanvito, L., C. S. Constantinescu and B. Gran (2011). Novel therapeutic approaches to autoimmune demyelinating disorders. Curr Pharm Des 17(29): 3191-3201.
Sanvito, L., A. Tomita, N. Chihara, T. Okamoto, Y. Lin, M. Ogawa, B. Gran, T. Aranami and T. Yamamura (2011). Increase of Ki-67+ natural killer cells in multiple sclerosis patients treated with interferon-beta and interferon-beta combined with low-dose oral steroids. J Neuroimmunol 236(1-2): 111-117.
Tallantyre, E. C., J. E. Dixon, I. Donaldson, T. Owens, P. S. Morgan, P. G. Morris and N. Evangelou (2011). Ultra-high-field imaging distinguishes MS lesions from asymptomatic white matter lesions. Neurology 76(6): 534-539.
Braitch, M., K. Kawabe, M. Nyirenda, L. J. Gilles, R. A. Robins, B. Gran, S. Murphy, L. Showe and C. S. Constantinescu (2010). Expression of activity-dependent neuroprotective protein in the immune system: possible functions and relevance to multiple sclerosis. Neuroimmunomodulation 17(2): 120-125.
Constantinescu, C. S. and B. Gran (2010). Multiple sclerosis: autoimmune associations in multiple sclerosis. Nat Rev Neurol 6(11): 591-592.
Farooqi, N., B. Gran and C. S. Constantinescu (2010). Are current disease-modifying therapeutics in multiple sclerosis justified on the basis of studies in experimental autoimmune encephalomyelitis? J Neurochem 115(4): 829-844.
GRAN, B. and B. BECHER (2010). Dual and Opposite Actions of Cytokines in Autoimmune Inflammatory Demyelination. The Open Autoimmunity Journal 2: 139-140.
Gran, B., S. Yu, G. X. Zhang and A. Rostami (2010). Accelerated thymocyte maturation in IL-12Rbeta2-deficient mice contributes to increased susceptibility to autoimmune inflammatory demyelination. Exp Mol Pathol 89(2): 126-134.
Jean-Gilles, L., B. Gran and C. S. Constantinescu (2010). Interaction between cytokines, cannabinoids and the nervous system. Immunobiology 215(8): 606-610.
O'Brien, K., D. Fitzgerald, A. Rostami and B. Gran (2010). The TLR7 agonist, imiquimod, increases IFN-beta production and reduces the severity of experimental autoimmune encephalomyelitis. J Neuroimmunol 221(1-2): 107-111.
O'Brien, K., B. Gran and A. Rostami (2010). T-cell based immunotherapy in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunotherapy 2(1): 99-115.
Sanvito, L., C. S. Constantinescu, B. GraN and B. A. Hart (2010). The multifaceted role of Interferon-gamma in central nervous system autoimmune demyelination. The Open Autoimmunity Journal 2: 151-159.
Sotiropoulos, S. N., L. Bai, P. S. Morgan, C. S. Constantinescu and C. R. Tench (2010). Brain tractography using Q-ball imaging and graph theory: Improved connectivities through fibre crossings via a model-based approach. Neuroimage 49(3): 2444-2456.
Sotiropoulos, S. N., L. Bai and C. R. Tench (2010). Fuzzy anatomical connectedness of the brain using single and multiple fibre orientations estimated from diffusion MRI. Comput Med Imaging Graph 34(6): 504-513.
Tallantyre, E. C., L. Bo, O. Al-Rawashdeh, T. Owens, C. H. Polman, J. S. Lowe and N. Evangelou (2010). Clinico-pathological evidence that axonal loss underlies disability in progressive multiple sclerosis. Mult Scler 16(4): 406-411.
Tallantyre, E. C., P. S. Morgan, J. E. Dixon, A. Al-Radaideh, M. J. Brookes, P. G. Morris and N. Evangelou (2010). 3 Tesla and 7 Tesla MRI of multiple sclerosis cortical lesions. J Magn Reson Imaging 32(4): 971-977.
Tench, C. R. and C. S. Constantinescu (2010). Conventional and Quantitative Magnetic Resonance Imaging and
Cognitive Impairment in Multiple Sclerosis. European Neurological Review In Press.
TOUIL, T., N. CHU, U. BOHLMANN, P. BARGSTEN, D. Fitzgerald, G. X. ZHANG, B. BECHER, A. M. ROSTAMI and B. GrAN (2010). paradoxical effect of systemic IL-23 in EAE – Limitation of autoimmune inflammatory demyelination. The Open Autoimmunity Journal 2: 141-150.
Braitch, M., S. Harikrishnan, R. A. Robins, C. Nichols, A. J. Fahey, L. Showe and C. S. Constantinescu (2009). Glucocorticoids increase CD4CD25 cell percentage and Foxp3 expression in patients with multiple sclerosis. Acta Neurol Scand 119(4): 239-245.
Braitch, M., K. Kawabe, M. Nyirenda, L. J. Gilles, R. A. Robins, B. Gran, S. Murphy, L. Showe and C. S. Constantinescu (2009). Expression of Activity-Dependent Neuroprotective Protein in the Immune System: Possible Functions and Relevance to Multiple Sclerosis. Neuroimmunomodulation 17(2): 120-125.
Dineen, R. A., J. Vilisaar, J. Hlinka, C. M. Bradshaw, P. S. Morgan, C. S. Constantinescu and D. P. Auer (2009). Disconnection as a mechanism for cognitive dysfunction in multiple sclerosis. Brain 132(Pt 1): 239-249.
Edwards, L. J. and C. S. Constantinescu (2009). Platelet activating factor/platelet activating factor receptor pathway as a potential therapeutic target in autoimmune diseases. Inflamm Allergy Drug Targets 8(3): 182-190.
Francis, S., X. Lin, S. Aboushoushah, T. P. White, M. Phillips, R. Bowtell and C. S. Constantinescu (2009). fMRI analysis of active, passive and electrically stimulated ankle dorsiflexion. Neuroimage 44(2): 469-479.
Gilmore, C. P., G. C. DeLuca, L. Bo, T. Owens, J. Lowe, M. M. Esiri and N. Evangelou (2009). Spinal cord neuronal pathology in multiple sclerosis. Brain Pathol 19(4): 642-649.
Gilmore, C. P., I. Donaldson, L. Bo, T. Owens, J. Lowe and N. Evangelou (2009). Regional variations in the extent and pattern of grey matter demyelination in multiple sclerosis: a comparison between the cerebral cortex, cerebellar cortex, deep grey matter nuclei and the spinal cord. J Neurol Neurosurg Psychiatry 80(2): 182-187.
Gilmore, C. P., J. J. Geurts, N. Evangelou, J. C. Bot, R. A. van Schijndel, P. J. Pouwels, F. Barkhof and L. Bo (2009). Spinal cord grey matter lesions in multiple sclerosis detected by post-mortem high field MR imaging. Mult Scler 15(2): 180-188.
Gilmore, C. P., A. Jacob and N. Evangelou (2009). A case of neuromyelitis optica with gadolinium-enhancing brain lesions and Parinaud syndrome. Arch Neurol 66(1): 140; author reply 140-141.
Jean-Gilles, L., S. Feng, C. R. Tench, V. Chapman, D. A. Kendall, D. A. Barrett and C. S. Constantinescu (2009). Plasma endocannabinoid levels in multiple sclerosis. J Neurol Sci 287(1-2): 212-215.
Kubajewska, I. and C. S. Constantinescu (2009). Cannabinoids and experimental models of multiple sclerosis. Immunobiology.
Nyirenda, M. H., K. O'Brien, L. Sanvito, C. S. Constantinescu and B. Gran (2009). Modulation of regulatory T cells in health and disease: role of toll-like receptors. Inflamm Allergy Drug Targets 8(2): 124-129.
Tallantyre, E. C., L. Bo, O. Al-Rawashdeh, T. Owens, C. H. Polman, J. Lowe and N. Evangelou (2009). Greater loss of axons in primary progressive multiple sclerosis plaques compared to secondary progressive disease. Brain 132(Pt 5): 1190-1199.
Tallantyre, E. C., P. S. Morgan, J. E. Dixon, A. Al-Radaideh, M. J. Brookes, N. Evangelou and P. G. Morris (2009). A comparison of 3T and 7T in the detection of small parenchymal veins within MS lesions. Invest Radiol 44(9): 491-494.
Zellini, F., G. Niepel, C. R. Tench and C. S. Constantinescu (2009). Hypothalamic involvement assessed by T1 relaxation time in patients with relapsing-remitting multiple sclerosis. Mult Scler 15(12): 1442-1449.
Braitch, M., R. Nunan, G. Niepel, L. J. Edwards and C. S. Constantinescu (2008). Increased osteopontin levels in the cerebrospinal fluid of patients with multiple sclerosis. Arch Neurol 65(5): 633-635.
Edwards, L. J., J. C. Atherton, A. M. Zaitoun and C. S. Constantinescu (2008). A case of dysphagia with clinically isolated syndrome. Mult Scler 14(5): 716-717.
Lin, X., C. R. Tench, P. S. Morgan and C. S. Constantinescu (2008). Use of combined conventional and quantitative MRI to quantify pathology related to cognitive impairment in multiple sclerosis. J Neurol Neurosurg Psychiatry 79(4): 437-441.
O'Brien, K., D. C. Fitzgerald, K. Naiken, K. R. Alugupalli, A. M. Rostami and B. Gran (2008). Role of the innate immune system in autoimmune inflammatory demyelination. Curr Med Chem 15(11): 1105-1115.
Sotiropoulos, S. N., L. Bai, P. S. Morgan, D. P. Auer, C. S. Constantinescu and C. R. Tench (2008). A regularized two-tensor model fit to low angular resolution diffusion images using basis directions. J Magn Reson Imaging 28(1): 199-209.
Tallantyre, E., N. Evangelou and C. S. Constantinescu (2008). Spotlight on teriflunomide. Int MS J 15(2): 62-68.
Tallantyre, E. C., M. J. Brookes, J. E. Dixon, P. S. Morgan, N. Evangelou and P. G. Morris (2008). Demonstrating the perivascular distribution of MS lesions in vivo with 7-Tesla MRI. Neurology 70(22): 2076-2078.
Vilisaar, J., S. Harikrishnan, M. Suri and C. S. Constantinescu (2008). Ehlers-Danlos syndrome and multiple sclerosis: a possible association. Mult Scler 14(4): 567-570.
Bosley, T. M., C. S. Constantinescu, C. R. Tench and K. K. Abu-Amero (2007). Mitochondrial changes in leukocytes of patients with optic neuritis. Mol Vis 13: 1516-1528.
Edwards, L. J., C. R. Tench, C. P. Gilmore, N. Evangelou and C. S. Constantinescu (2007). Multiple sclerosis findings in the spinal cord. Expert Rev Neurother 7(9): 1203-1211.
Fahey, A. J., R. Adrian Robins and C. S. Constantinescu (2007). Curcumin modulation of IFN-beta and IL-12 signalling and cytokine induction in human T cells. J Cell Mol Med 11(5): 1129-1137.
Fahey, A. J., R. A. Robins and C. S. Constantinescu (2007). Reciprocal effects of IFN-beta and IL-12 on STAT4 activation and cytokine induction in T cells. J Leukoc Biol 81(6): 1562-1567.
Mann, R. S., C. S. Constantinescu and C. R. Tench (2007). Upper cervical spinal cord cross-sectional area in relapsing remitting multiple sclerosis: application of a new technique for measuring cross-sectional area on magnetic resonance images. J Magn Reson Imaging 26(1): 61-65.
Constantinescu, C. S., M. Thomas and A. G. Zaman (2006). Atopic optic neuritis. Ocul Immunol Inflamm 14(2): 125-127.
Fahey, A. J., R. A. Robins, K. B. Kindle, D. M. Heery and C. S. Constantinescu (2006). Effects of glucocorticoids on STAT4 activation in human T cells are stimulus-dependent. J Leukoc Biol 80(1): 133-144.
Niepel, G., R. Tench Ch, P. S. Morgan, N. Evangelou, D. P. Auer and C. S. Constantinescu (2006). Deep gray matter and fatigue in MS: a T1 relaxation time study. J Neurol 253(7): 896-902.
Vilisaar, J. and C. S. Constantinescu (2006). SUNCT in multiple sclerosis. Cephalalgia 26(7): 891-893.
Lin, X., C. R. Tench, P. S. Morgan, G. Niepel and C. S. Constantinescu (2005). 'Importance sampling' in MS: use of diffusion tensor tractography to quantify pathology related to specific impairment. J Neurol Sci 237(1-2): 13-19.
Tench, C. R., P. S. Morgan and C. S. Constantinescu (2005). Measurement of cervical spinal cord cross-sectional area by MRI using edge detection and partial volume correction. J Magn Reson Imaging 21(3): 197-203.
Tench, C. R., P. S. Morgan, T. Jaspan, D. P. Auer and C. S. Constantinescu (2005). Spinal cord imaging in multiple sclerosis. J Neuroimaging 15(4 Suppl): 94S-102S.
Vilisaar, J., M. Wilson, G. Niepel, L. D. Blumhardt and C. S. Constantinescu (2005). A comparative audit of anticardiolipin antibodies in oligoclonal band negative and positive multiple sclerosis. Mult Scler 11(4): 378-380.
Edwards, L. J. and C. S. Constantinescu (2004). A prospective study of conditions associated with multiple sclerosis in a cohort of 658 consecutive outpatients attending a multiple sclerosis clinic. Mult Scler 10(5): 575-581.
Lin, X., C. R. Tench, N. Evangelou, T. Jaspan and C. S. Constantinescu (2004). Measurement of spinal cord atrophy in multiple sclerosis. J Neuroimaging 14(3 Suppl): 20S-26S.
Lin, X., L. D. Blumhardt and C. S. Constantinescu (2003). The relationship of brain and cervical cord volume to disability in clinical subtypes of multiple sclerosis: a three-dimensional MRI study. Acta Neurol Scand 108(6): 401-406.
Lin, X., C. R. Tench, B. Turner, L. D. Blumhardt and C. S. Constantinescu (2003). Spinal cord atrophy and disability in multiple sclerosis over four years: application of a reproducible automated technique in monitoring disease progression in a cohort of the interferon beta-1a (Rebif) treatment trial. J Neurol Neurosurg Psychiatry 74(8): 1090-1094.
Vaithianathar, L., C. R. Tench, P. S. Morgan and C. S. Constantinescu (2003). Magnetic resonance imaging of the cervical spinal cord in multiple sclerosis--a quantitative T1 relaxation time mapping approach. J Neurol 250(3): 307-315.
Tench, C. R., P. S. Morgan, L. D. Blumhardt and C. Constantinescu (2002). Improved white matter fiber tracking using stochastic labeling. Magn Reson Med 48(4): 677-683.
Tench, C. R., P. S. Morgan, M. Wilson and L. D. Blumhardt (2002). White matter mapping using diffusion tensor MRI. Magn Reson Med 47(5): 967-972.