Research Projects
Most of our research focuses on atopic eczema because the disease is so common, its prevalence is rising, it causes a lot of suffering, and we understand little about its causes, treatment and prevention. Our other diseases of interest include non-melanoma skin cancer, vitiligo, cellulitis, rare skin disorders and other conditions.
Studies by themes
Eczema
Acronymn
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Project Title
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Funded by
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Status
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CEBD Investigator(s)
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BEEP
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Barrier Enhancement for Eczema Prevention: The BEEP feasibility study (www.beepstudy.org)
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NIHR Programme Grant
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Ongoing
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Joanne Chalmers, Kim Thomas, Hywel Williams
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Eczema Treatment Review
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Systematic review of treatments for atopic eczema - "An update of the 2000 Eczema Treatments Review"
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NIHR Programme Grant
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Ongoing
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Finola Delamere, Helen Nankervis, Kim Thomas, Hywel Williams
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Eczema Prioritisation Partnership
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Working in collaboration with the James Lind Alliance to establish treatment uncertainties that should be prioritised for further research (www.homeforeczema.org.uk)
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NIHR Programme Grant
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Completed
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Jonathan Batchelor, Tessa Clarke, Margaret McPhee, Jane Ravenscroft, Kim Thomas
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HOME initiative
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Harmonizing Outcome Measures for Eczema (www.homeforeczema.org.uk)
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NIHR Programme Grant
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Ongoing
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Joanne Chalmers, Helen Nankervis, Kim Thomas, Hywel Williams
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Eczema prevention umbrella review
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The prevention of eczema in infants and children: An overview of Cochrane and non-Cochrane reviews
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NIHR Programme Grant
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Completed
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Joanne Chalmers, Hywel Williams
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SWET
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Softened Water Eczema Trial (http://www.swet-trial.co.uk/)
[See Press Release]
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NIHR Health Technology Assessment
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Completed
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Karin Koller, Kim Thomas, Hywel Williams
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|
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A prospective observational study of environmental factors affecting atopic eczema in children
Further papers:
-- http://www.ncbi.nlm.nih.gov/pubmed/16634905;
-- http://www.ncbi.nlm.nih.gov/pubmed/16911274
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BUPA Foundation & Bastow Research grant from the Special Trustees for Nottingham University Hospitals
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Completed
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Sinéad Langan, Hywel Williams
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Scratch meters as an outcome measure for eczema research
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Queen's Medical Centre University Hospital NHS Trust
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Completed
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Karin Koller, Kim Thomas
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Feasibility study for a randomised controlled trial of water softeners in the treatment of atopic eczema
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Kinetico UK Ltd
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Completed
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Kim Thomas, Hywel Williams
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Randomised controlled trial of short bursts of a potent topical corticosteroid versus prolonged use of a mild preparation for children with mild or moderate atopic eczema
Published:
http://www.ncbi.nlm.nih.gov/pubmed/11923161
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NHS Research and Development Programme (Trent)
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Completed
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Kim Thomas, Hywel Williams
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A randomised controlled trial of nurse follow-up clinics: do they help patients and do they free up consultants' time?
Published:
http://www.ncbi.nlm.nih.gov/pubmed/12207593
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Crookes Healthcare
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Completed
|
Kim Thomas
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International Study of Asthma and Allergies in Childhood (ISAAC) (http://isaac.auckland.ac.nz)
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Completed
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Hywel Williams
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Non-melanoma skin cancer
Acronym
|
Project Title
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Funded by
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Status
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CEBD Investigator(s)
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SINS
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Surgery vs imiquimod for nodular and superficial basal cell carcinoma
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Cancer Research UK (imiquimod kindly provided by 3M)
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Ongoing
|
Fiona Bath-Hextall, Mara Ozolins, Hywel Williams
|
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LIMIT-1
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Effect of topical imiquimod on lentigo maligna (Phase II RCT) (www.ukdctn.org/ongoing/limit/)
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NIHR Research for Patient Benefit
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Completed
|
Nazia Boota
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Raman imaging
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Raman spectral imaging for automated Mohs micrographic surgery of high-risk basal cell carcinoma
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NIHR i4i
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Ongoing
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Hywel Williams
|
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Squamous Cell Carcinoma (SCC) audit
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Feasibility work to inform the development and design of an RCT for improving outcomes for the treatment of SCC
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NIHR Programme Grant
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Ongoing
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Fiona Bath-Hextall, Louise Lansbury
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Treatments for Squamous Cell Carcinoma (SCC)
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Interventions for non-metastatic squamous cell carcinoma of the skin (www.thecochranelibrary.org)
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NIHR Programme Grant
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Completed
|
Fiona Bath-Hextall, Louise Lansbury
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Review of observational studies for the treatment of SCC
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A systematic review of observational studies of interventions for primary, non-metastatic SCC of the skin
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NIHR Programme Grant
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Ongoing
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Fiona Bath-Hextall, Louise Lansbury
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|
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Pilot study to examine patterns in incidence, risk factors and treatments in primary care using the THIN database
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University of Nottingham and NHS R&D Support Funding
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Completed
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Fiona Bath-Hextall
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Vitiligo
Acronym
|
Project Title
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Funded by
|
Status
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CEBD Investigator(s)
|
|
HI-Light for vitiligo
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Pilot RCT of hand-held NB-UVB for the treatment of focal and early vitiligo at home (www.vitiligostudy.org.uk)
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NIHR Programme Grant
|
Recruiting
|
Jonathan Batchelor, Viktoria Eleftheriadou, Kim Thomas, Hywel Williams
|
|
Vitiligo Prioritisation Partnership
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Working in collaboration with the James Lind Alliance to establish treatment uncertainties that should be prioritised for further research
Vitiligo PSP results
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NIHR Programme Grant
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Completed
|
Jonathan Batchelor, Viktoria Eleftheriadou, Kim Thomas, Hywel Williams
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Cellulitis
Acronym
|
Project Title
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Funded by
|
Status
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CEBD Investigator(s)
|
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PATCH I
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Randomised controlled trial to investigate whether prophylactic antibiotics can prevent further episodes of cellulitis of the leg (www.patchtrial.co.uk)
|
Action Medical Research
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Completed
|
Joanne Chalmers, Katharine Foster, Kim Thomas, Hywel Williams
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PATCH II
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Randomised controlled trial to investigate whether prophylactic antibiotics can prevent further episodes of cellulitis of the leg
Published: http://www.ncbi.nlm.nih.gov/pubmed/2190701
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BUPA Foundation
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Completed
|
Joanne Chalmers, Katharine Foster, Kim Thomas, Hywel Williams
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Rare skin conditions
Acronym
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Project Title
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Funded by
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Status
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CEBD Investigator(s)
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STOP GAP
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A randomised controlled trial comparing the use of prednisolone and ciclosporin for the treatment of pyoderma gangrenosum (www.stopgaptrial.co.uk)
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NIHR Programme Grant
|
Recruiting
|
Eleanor Mitchell, Katharine Foster, Kim Thomas, Hywel Williams
|
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BLISTER
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A randomised controlled trial to compare the safety and effectiveness of doxycycline (200mg/day) with prednisolone (0.5mg/kg/day) for initial treatment of bullous pemphigoid (www.blistertrial.co.uk)
|
NIHR Health Technology Assessment Programme
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Recruiting
|
Joanne Chalmers, Caroline Onions, Hywel Williams
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Erosive Lichen Planus case note audit
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Case note review of normal practice for the treatment of erosive lichen planus of the vulva (EVLP) in 11 UK hospitals
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Nottingham University Hospitals NHS Trust
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Ongoing
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Ruth Murphy, Rosalind Simpson
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Other studies
Acronym
|
Project Title
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Funded by
|
Status
|
CEBD Investigator(s)
|
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EVerT
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Effective Verrucae Treatment (http://www.verrucatrial.co.uk/)
Published:
|
NIHR Health Technology Assessment
|
Completed
|
Kim Thomas
|
|
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Randomised controlled multiple treatment comparison to provide a cost-effectiveness rationale for the selection of antimicrobial therapy in acne
|
NIHR Health Technology Assessment
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Completed
|
Mara Ozolins, Hywel Williams
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Should eye protection be worn during dermatological surgery: prospective observational study. [PubMed Abstract]
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Completed
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Kim Thomas
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