Dominick Shaw

Contact

• workRoom B21 CSB
  Nottingham City Hospital
  Hucknall Road
  Nottingham
  NG5 1PB
  UK
• work0115 82 31709
• dominic.shaw@nottingham.ac.uk

Teaching Summary

Asthma, airways disease and respiratory emergencies, including provison of the respiratory taught course

Research Summary

Currently I have 3 areas of interest, all under the umbrella of asthma research. Firstly I am interested in the airway and airway epithelium. I have two projects; one examining the role of macrolide… read more

Selected Publications

• HALDAR, P., PAVORD, I.D., SHAW, D.E., BERRY, M.A., THOMAS, M., BRIGHTLING, C.E., WARDLAW, A.J. and GREEN, R.H., 2008. Cluster analysis and clinical asthma phenotypes American journal of respiratory and critical care medicine. 178(3), 218-224
• THOMAS, M., MCKINLEY, R.K., MELLOR, S., WATKIN, G., HOLLOWAY, E., SCULLION, J., SHAW, D.E., WARDLAW, A., PRICE, D. and PAVORD, I., 2009. Breathing exercises for asthma: a randomised controlled trial Thorax. 64(1), 55-61
• PATEL, MITESH, PILCHER, JANINE, TRAVERS, JUSTIN, PERRIN, KYLE, SHAW, DOMINICK, BLACK, PETER, WEATHERALL, MARK and BEASLEY, RICHARD, 2013. Use of Metered-Dose Inhaler Electronic Monitoring in a Real-World Asthma Randomized Controlled Trial: Journal of Allergy and Clinical Immunology: In Practice Journal of Allergy and Clinical Immunology: In Practice. 1(1), 83-91
• SHAW, D., GREEN, R., BERRY, M., MELLOR, S., HARGADON, B., SHELLEY, M., MCKENNA, S., THOMAS, M. and PAVORD, I., 2012. A cross-sectional study of patterns of airway dysfunction, symptoms and morbidity in primary care asthma: Prim Care Respir J Prim Care Respir J. 21(3), 283-7

• View all publications

Current Research

Currently I have 3 areas of interest, all under the umbrella of asthma research. Firstly I am interested in the airway and airway epithelium. I have two projects; one examining the role of macrolide antibiotics on the airway epithelium, using epithelial cells cultured from well phenotyped asthma patients and a second looking at distal airway inflammation using a small bronchial brush technique.

Continuing research from my thesis, I am evaluating the role of exhaled nitric oxide in treatment decisions in asthma care and have a funded study in this area.

Lastly I am investigating the role of the small airways in asthma using hyperpolarized xenon MRI imaging in animal models.

Future Research

I am interested in developing the non-invasive assessment of airways disease.

• MARTIN, M. and SHAW, D., 2013. Effect of inhaled corticosteroids on the microbiology of the respiratory tract: Respirology Respirology. 18(2), 201-2
• PATEL, MITESH, PILCHER, JANINE, TRAVERS, JUSTIN, PERRIN, KYLE, SHAW, DOMINICK, BLACK, PETER, WEATHERALL, MARK and BEASLEY, RICHARD, 2013. Use of Metered-Dose Inhaler Electronic Monitoring in a Real-World Asthma Randomized Controlled Trial: Journal of Allergy and Clinical Immunology: In Practice Journal of Allergy and Clinical Immunology: In Practice. 1(1), 83-91
• MITESH PATEL, JANINE PILCHER, ALISON PRITCHARD, KYLE PERRIN, JUSTIN TRAVERS, DOMINICK SHAW, SHAUN HOLT, MATIRE HARWOOD, PETER BLACK and MARK WEATHERALL, 2013. Efficacy and safety of maintenance and reliever combination budesonide—formoterol inhaler in patients with asthma at risk of severe exacerbations: a randomised controlled trial Lancet Respiratory. 1(1), 32-42
• BLAKEY, J.D., GUY, D., SIMPSON, C., FEARN, A., CANNABY, S., WILSON, P. and SHAW, D., 2012. Multimodal observational assessment of quality and productivity benefits from the implementation of wireless technology for out of hours working BMJ Open. 2(2), e000701
• SHAW, D., GREEN, R., BERRY, M., MELLOR, S., HARGADON, B., SHELLEY, M., MCKENNA, S., THOMAS, M. and PAVORD, I., 2012. A cross-sectional study of patterns of airway dysfunction, symptoms and morbidity in primary care asthma: Prim Care Respir J Prim Care Respir J. 21(3), 283-7
• SHAW, D.E., WILSON, E. and PAVORD, I.D, 2010. Exhaled nitric oxide in asthma: European Respiratory Monograph European Respiratory Monograph. 32-44
• SHAW, D., 2009. Exhaled nitric oxide: time to employ or make redundant?: Chron.Respir.Dis. Chron.Respir.Dis.. 6(1), 3-4
• THOMAS, M., MCKINLEY, R.K., MELLOR, S., WATKIN, G., HOLLOWAY, E., SCULLION, J., SHAW, D.E., WARDLAW, A., PRICE, D. and PAVORD, I., 2009. Breathing exercises for asthma: a randomised controlled trial Thorax. 64(1), 55-61
• HALDAR, P., PAVORD, I.D., SHAW, D.E., BERRY, M.A., THOMAS, M., BRIGHTLING, C.E., WARDLAW, A.J. and GREEN, R.H., 2008. Cluster analysis and clinical asthma phenotypes American journal of respiratory and critical care medicine. 178(3), 218-224
• PAVORD, I. D. and SHAW, D., 2008. The use of exhaled nitric oxide in the management of asthma: J Asthma J Asthma. 45(7), 523-531
• PAVORD, I. D., SHAW, D. E., GIBSON, P. G. and TAYLOR, D. R., 2008. Inflammometry to assess airway diseases: Lancet Lancet. 372(9643), 1017-1019
• BERRY, M., MORGAN, A., SHAW, D. E., PARKER, D., GREEN, R., BRIGHTLING, C., BRADDING, P., WARDLAW, A. J. and PAVORD, I. D., 2007. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma: Thorax Thorax. 62(12), 1043-9
• SHAW, D. E., BERRY, M. A., HARGADON, B., MCKENNA, S., SHELLEY, M. J., GREEN, R. H., BRIGHTLING, C. E., WARDLAW, A. J. and PAVORD, I. D., 2007. Association between neutrophilic airway inflammation and airflow limitation in adults with asthma: Chest Chest. 132(6), 1871-5
• SHAW, D. E., BERRY, M. A., THOMAS, M., GREEN, R. H., BRIGHTLING, C. E., WARDLAW, A. J. and PAVORD, I. D., 2007. The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial: Am.J Respir.Crit Care Med Am.J Respir.Crit Care Med. 176(3), 231-237
• BERRY, M. A., HARGADON, B., SHELLEY, M., PARKER, D., SHAW, D. E., GREEN, R. H., BRADDING, P., BRIGHTLING, C. E., WARDLAW, A. J. and PAVORD, I. D., 2006. Evidence of a role of tumor necrosis factor alpha in refractory asthma: N.Engl.J.Med. N.Engl.J.Med.. 354(7), 697-708
• BERRY, M., HARGADON, B., MORGAN, A., SHELLEY, M., RICHTER, J., SHAW, D., GREEN, R. H., BRIGHTLING, C., WARDLAW, A. J. and PAVORD, I. D., 2005. Alveolar nitric oxide in adults with asthma: evidence of distal lung inflammation in refractory asthma: Eur.Respir.J Eur.Respir.J. 25(6), 986-991
• BERRY, M. A., HARGADON, B., MCKENNA, S., SHAW, D., GREEN, R. H., BRIGHTLING, C. E., WARDLAW, A. J. and PAVORD, I. D., 2005. Observational study of the natural history of eosinophilic bronchitis: Clin Exp Allergy Clin Exp Allergy. 35(5), 598-601
• BERRY, M. A., SHAW, D. E., GREEN, R. H., BRIGHTLING, C. E., WARDLAW, A. J. and PAVORD, I. D., 2005. The use of exhaled nitric oxide concentration to identify eosinophilic airway inflammation: an observational study in adults with asthma: Clin Exp Allergy Clin Exp Allergy. 35(9), 1175-1179
• SHAW, D. E., GREEN, R. H. and BRADDING, P., 2005. Asthma exacerbations: prevention is better than cure: Ther.Clin.Risk Manag. Ther.Clin.Risk Manag.. 1(4), 273-277
• SHAW, D., PRIESTMAN, W. and MCINTYRE, C. W., 2002. Benign intracranial hypertension in a patient with chronic renal failure, precipitated by hemodialysis: Clin Nephrol. Clin Nephrol.. 58(6), 458-460