Research
Research areas
The Division of Stroke is involved in research into the following areas:
Acute management
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Efficacy of Nitric Oxide in Stroke trial (ENOS)
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Blood pressure in Acute Stroke Collaboration (BASC)
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Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS)
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A randomised controlled trial of Tranexamic acid in Intracerebral Haemorrhage (TICH)
Systematic reviews - Cochrane Collaboration
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Acute interventions
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Secondary prevention
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Recovery and rehabilitation
Prevention
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Prevention of post-stroke cognitive decline and dementia (PODCAST)
Translational stroke studies
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Blood-brain barrier (BBB) and cerebrovascular disease: brain oedema
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Hyperglycaemia and the BBB pathophysiology: protein kinase C signalling pathway
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Ischaemic injury and the BBB integrity: small GTP-binding protein RhoA, ROCK, MLC
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Matrix metalloproteases (MMP-2, MMP-9) and plasminogen-plasmin system components(uPA, uPAR, tPA, PA-1)
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Neuropinflammation:cytokines, chemokines
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Hypothermia: tight junction proteins (occuludin, ZO-1, claudin-5 etc)
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Oxidative stress: NOSs, SODs, catalase, GPx, ROS, NO
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Clinical biomarkers
Research expertise
The Division of Stroke has research expertise in the following areas:
Clinical pharmacology / therapeutics
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Phase I trials in volunteers
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Phase II and phase III trials in acute stroke, stroke recovery and stroke prevention
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Meta-analysis using both summary and individual patient data
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Data (safety) monitoring committees
Experimental methodologies
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In vitro models of human BBB
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Measurements of transendothelial electrical resistance and paracellular flux
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Molecular biological methodologies including in-cell Western analyses, cell imaging, RT-PCR, siRNA transfection
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Biochemical analyses including enzyme activity measurements
PhD Scholarships for international students - please see link below
http://www.nottingham.ac.uk/scs/study/postgraduate-research-degrees/phd-projects-self-funded.aspx