Recent Publications
2012
Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research.
Stewart CE, Torr EE, Mohd Jamili NH, Bosquillon C, Sayers I.
J Allergy (Cairo). 2012;2012:943982. Epub 2012 Jan 11. PubMed
Characterization of protocadherin-1 expression in primary bronchial epithelial cells: association with epithelial cell differentiation.
Koning H, Sayers I, Stewart CE, de Jong D, Ten Hacken NH, Postma DS, van Oosterhout AJ, Nawijn MC, Koppelman GH.
FASEB J. 2012 Jan;26(1):439-48. PubMed
2011
The role of ALOX5AP, LTA4H and LTB4R polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers.
Tulah AS, Parker SG, Moffatt MF, Wardlaw AJ, Connolly MJ, Sayers I.
BMC Med Genet. 2011 Dec 29;12:173. PubMed
uPAR regulates bronchial epithelial repair in vitro and is elevated in asthmatic epithelium.
Stewart CE, Nijmeh HS, Brightling CE, Sayers I.
Thorax. 2011 Dec 3. PubMed
Novel cyclic AMP Signalling Paradigms: Therapeutic Implications for Airway Disease.
Billington CK, Hall IP.
Br J Pharmacol. 2011 Oct 20. PubMed
Real time analysis of β(2)-adrenoceptor-mediated signaling kinetics in human primary airway smooth muscle cells reveals both ligand and dose dependent differences.
Billington CK, Hall IP.
Respir Res. 2011 Jul 2;12:89. PubMed
Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function.
Soler Artigas M, Wain LV, Repapi E, Obeidat M, Sayers I, Burton PR, Johnson T, Zhao JH, Albrecht E, Dominiczak AF, Kerr SM, Smith BH, Cadby G, Hui J, Palmer LJ, Hingorani AD, Wannamethee SG, Whincup PH, Ebrahim S, Smith GD, Barroso I, Loos RJ, Wareham NJ, Cooper C, Dennison E, Shaheen SO, Liu JZ, Marchini J; Medical Research Council National Survey of Health and Development (NSHD) Respiratory Study Team, Dahgam S, Naluai AT, Olin AC, Karrasch S, Heinrich J, Schulz H, McKeever TM, Pavord ID, Heliövaara M, Ripatti S, Surakka I, Blakey JD, Kähönen M, Britton JR, Nyberg F, Holloway JW, Lawlor DA, Morris RW, James AL, Jackson CM, Hall IP, Tobin MD; SpiroMeta Consortium.
Am J Respir Crit Care Med. 2011 Oct 1;184(7):786-95. PubMed
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.
Soler Artigas M, Loth DW, Wain LV, Gharib SA, Obeidat M, Tang W, Zhai G, Zhao JH, Smith AV, Huffman JE, Albrecht E, Jackson CM, Evans DM, Cadby G, Fornage M, Manichaikul A, Lopez LM, Johnson T, Aldrich MC, Aspelund T, Barroso I, Campbell H, Cassano PA, Couper DJ, Eiriksdottir G, Franceschini N, Garcia M, Gieger C, Gislason GK, Grkovic I, Hammond CJ, Hancock DB, Harris TB, Ramasamy A, Heckbert SR, Heliövaara M, Homuth G, Hysi PG, James AL, Jankovic S, Joubert BR, Karrasch S, Klopp N, Koch B, Kritchevsky SB, Launer LJ, Liu Y, Loehr LR, Lohman K, Loos RJ, Lumley T, Al Balushi KA, Ang WQ, Barr RG, Beilby J, Blakey JD, Boban M, Boraska V, Brisman J, Britton JR, Brusselle GG, Cooper C, Curjuric I, Dahgam S, Deary IJ, Ebrahim S, Eijgelsheim M, Francks C, Gaysina D, Granell R, Gu X, Hankinson JL, Hardy R, Harris SE, Henderson J, Henry A, Hingorani AD, Hofman A, Holt PG, Hui J, Hunter ML, Imboden M, Jameson KA, Kerr SM, Kolcic I, Kronenberg F, Liu JZ, Marchini J, McKeever T, Morris AD, Olin AC, Porteous DJ, Postma DS, Rich SS, Ring SM, Rivadeneira F, Rochat T, Sayer AA, Sayers I, Sly PD, Smith GD, Sood A, Starr JM, Uitterlinden AG, Vonk JM, Wannamethee SG, Whincup PH, Wijmenga C, Williams OD, Wong A, Mangino M, Marciante KD, McArdle WL, Meibohm B, Morrison AC, North KE, Omenaas E, Palmer LJ, Pietiläinen KH, Pin I, Pola Sbreve Ek O, Pouta A, Psaty BM, Hartikainen AL, Rantanen T, Ripatti S, Rotter JI, Rudan I, Rudnicka AR, Schulz H, Shin SY, Spector TD, Surakka I, Vitart V, Völzke H, Wareham NJ, Warrington NM, Wichmann HE, Wild SH, Wilk JB, Wjst M, Wright AF, Zgaga L, Zemunik T, Pennell CE, Nyberg F, Kuh D, Holloway JW, Boezen HM, Lawlor DA, Morris RW, Probst-Hensch N; International Lung Cancer Consortium; GIANT consortium, Kaprio J, Wilson JF, Hayward C, Kähönen M, Heinrich J, Musk AW, Jarvis DL, Gläser S, Järvelin MR, Ch Stricker BH, Elliott P, O'Connor GT, Strachan DP, London SJ, Hall IP, Gudnason V, Tobin MD.
Nat Genet. 2011 Sep 25;43(11):1082-90. PubMed
Interstitial lung disease following certolizumab pegol.
Pearce F, Johnson SR, Courtney P.
Rheumatology (Oxford). 2011 Nov 23. PubMed
Use of variability in national and regional data to estimate the prevalence of lymphangioleiomyomatosis.
Harknett EC, Chang WY, Byrnes S, Johnson J, Lazor R, Cohen MM, Gray B, Geiling S, Telford H, Tattersfield AE, Hubbard RB, Johnson SR.
QJM. 2011 Nov;104(11):971-9. PubMed
Matrix metalloproteinase-12 (MMP-12) SNP affects MMP activity, lung macrophage infiltration and protects against emphysema in COPD.
Haq I, Lowrey GE, Kalsheker N, Johnson SR.
Thorax. 2011 Nov;66(11):970-6. PubMed
Evidence of a genetic contribution to lung function decline in asthma.
Koppelman GH, Sayers I.
J Allergy Clin Immunol. 2011 Sep;128(3):479-84. PubMed
A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample (2011) Obeidat M, Wain LV, Shrine N, Kalsheker N, Artigas MS, Repapi E, Burton PR, Johnson T, Ramasamy A, Zhao JH, Zhai G, Huffman JE, Vitart V, Albrecht E, Igl W, Hartikainen AL, Pouta A, Cadby G, Hui J, Palmer LJ, Hadley D, McArdle WL, Rudnicka AR, Barroso I, Loos RJ, Wareham NJ, Mangino M, Soranzo N, Spector TD, Gläser S, Homuth G, Völzke H, Deloukas P, Granell R, Henderson J, Grkovic I, Jankovic S, Zgaga L, Polašek O, Rudan I, Wright AF, Campbell H, Wild SH, Wilson JF, Heinrich J, Imboden M, Probst-Hensch NM, Gyllensten U, Johansson A, Zaboli G, Mustelin L, Rantanen T, Surakka I, Kaprio J, Jarvelin MR, Hayward C, Evans DM, Koch B, Musk AW, Elliott P, Strachan DP, Tobin MD, Sayers I, Hall IP, Consortium S. PLoS One. 6(5):e19382.PubMed
Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report (2011) Silverman EK, Vestbo J, Agusti A, Anderson W, Bakke PS, Barnes KC, Barr RG, Bleecker ER, Boezen HM, Burkart KM, Celli BR, Cho MH, Cookson WO, Croxton T, Daley D, DeMeo DL, Gan W, Garcia-Aymerich J, Hall IP, Hansel NN, Hersh CP, Kalsheker N, Kiley JP, Kim WJ, Lambrechts D, Lee SD, Litonjua AA, Lomas DA, London SJ, Nishimura M, Nørdestgaard BG, O'Donnell CJ, Postma DS, Puhan MA, Tesfaigzi Y, Tobin MD, Vogelmeier C, Wilk JB, Wouters E, Young RP, Ziegler-Heitbrock L, MacNee W, Crapo JD. COPD. 8(2):121-35. PubMed
A Genome-Wide Association Study to Identify Genetic Determinants of Atopy in U.K. Subjects (2011) Wan YI, Strachan DP, Evans DM, Henderson J, McKeever T, Holloway JW, Hall IP & Sayers I. JACI 127(1):223-231. PubMed
Current Progress in Pharmacogenetics (2011) Blakey JD, Hall IP. Br J Clin Pharmacol. (6):824-31. PubMed
Genetics of complex respiratory diseases: implications for pathophysiology and pharmacology studies (2011)Obeidat M, Hall IP. Br J Pharmacol. 163(1):96-105. PubMed
Impaired Uptake of Serotonin by Platelets from Patients with Irritable Bowel Syndrome Correlates with Duodenal Immune Activation (2011) Foley S, Garsed K, Singh G, Duroudier NP, Swan C, Hall IP, Zaitoun A, Bennett A, Marsden C, Holmes G, Walls A, Spiller RC. Gastroenterology. PubMed
The genetics of obstructive lung disease: big is beautiful.
Hall IP, Lomas DA.
Thorax. 2010 Sep;65(9):760-1. PubMed
2010
A large-scale, consortium-based genomewide association study of asthma.
Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, von Mutius E, Farrall M, Lathrop M, Cookson WO; GABRIEL Consortium.
N Engl J Med. 2010 Sep 23;363(13):1211-21. PubMed
A sequence variant on 17q21 is associated with age at onset and severity of asthma.
Halapi E, Gudbjartsson DF, Jonsdottir GM, Bjornsdottir US, Thorleifsson G, Helgadottir H, Williams C, Koppelman GH, Heinzmann A, Boezen HM, Jonasdottir A, Blondal T, Gudjonsson SA, Jonasdottir A, Thorlacius T, Henry AP, Altmueller J, Krueger M, Shin HD, Uh ST, Cheong HS, Jonsdottir B, Ludviksson BR, Ludviksdottir D, Gislason D, Park CS, Deichmann K, Thompson PJ, Wjst M, Hall IP, Postma DS, Gislason T, Kong A, Jonsdottir I, Thorsteinsdottir U, Stefansson K.
Eur J Hum Genet. 2010 Aug;18(8):902-8. PubMed
Reverse mode Na+/Ca2+ exchange mediated by STIM1 contributes to Ca2+ influx in airway smooth muscle following agonist stimulation (2011) Liu B, Peel SE, Fox J, Hall IP. Respir Res. 2010 Dec 2;11:168. PubMed
The ERS guidelines for LAM: trying a rationale approach to a rare disease (2010) Johnson SR. Respir Med. 104 Suppl 1:S33-41. PubMed
European Respiratory Society guidelines for the diagnosis and management of lymphangioleiomyomatosis (2010) Johnson SR, Cordier JF, Lazor R, Cottin V, Costabel U, Harari S, Reynaud-Gaubert M, Boehler A, Brauner M, Popper H, Bonetti F, Kingswood C; Review Panel of the ERS LAM Task Force. Eur Respir J. 35(1):14-26. PubMed
The International LAM Registry: a component of an innovative web-based clinician, researcher, and patient-driven rare disease research platform (2010) Nurok M, Eslick I, Carvalho CR, Costabel U, D'Armiento J, Glanville AR, Harari S, Henske EP, Inoue Y, Johnson SR, Lacronique J, Lazor R, Moss J, Ruoss SJ, Ryu JH, Seyama K, Watz H, Xu KF, Hohmann EL, Moss F. Lymphat Res Biol. 8(1):81-7. PubMed
Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production (2010) Roberts ME, Magowan L, Hall IP & Johnson SR. Eur Resp J. Sep 30. [Epub ahead of print]. PubMed
Role of the CXCR4/CXCL12 axis in lymphangioleiomyomatosis and angiomyolipoma (2010) Clements D, Markwick LJ, Puri N & Johnson SR. J. Immunol 1;185(3):1812-21. PubMed
Effect of doxycycline on proliferation, MMP production, and adhesion in LAM-related cells (2010) Chang WY, Clements D, Johnson SR. Am J Physiol Lung Cell Mol Physiol. 299(3):L393-400. PubMed
Atopy susceptibility and chromosome 19q13 (2010) Holloway JW, Barton SJ, & Sayers I. Allergy 65(6):802-4. PubMed
A GABRIEL consortium Large-Scale Genome-Wide Association Study of Asthma (2010) Gabriel consortium. New England Journal of Medicine 363(13):1211-21. PubMed
Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease (2010) Beghé B, Hall IP, Parker SG, Moffatt MF, Wardlaw A, Connolly MJ, Fabbri LM, Ruse C & Sayers I. Allergy 65(4):474-81. PubMed
Can lineage specific markers be identified to characterize mesenchyme-derived cell populations in the human airways? (2010) Singh S, Billington CK, Sayers I & Hall IP. Am J Physiol Lung Cell Mol Physiol. 299(2):L169-83. PubMed
Association of MMP-12 polymorphisms with severe and very severe COPD: A case control study of MMPs -1, 9 and 12 in a European population (2010) Imran Haq, Sally Chappell, Simon R Johnson, Juzer Lotya, Leslie Daly, Kevin Morgan, Tamar Guetta-Baranes, Josep Roca, Roberto Rabinovich, Ann Millar, Seamas C Donnelly, Vera Keatings, William MacNee, Jan Stolk, Pieter S Hiemstra, Massimo Miniati, Simonetta Monti, Clare M O'Connor and Noor Kalsheker. BMC Medical Genetics 15;11:7. PubMed
Genome-wide association study identifies five new loci associated with lung function (2010) Repapi E, Sayers I, Wain LV, Burton PR, Johnson T, Obeidat M, Zhao JH, Ramasamy A, Zhai G, Vitart V, Huffman JE, Igl W, Albrecht E, Deloukas P, Henderson J, Granell R, McArdle WL, Rudnicka AR; Wellcome Trust Case Control Consortium, Barroso I, Loos RJ, Wareham NJ, Mustelin L, Rantanen T, Surakka I, Imboden M, Wichmann HE, Grkovic I, Jankovic S, Zgaga L, Hartikainen AL, Peltonen L, Gyllensten U, Johansson A, Zaboli G, Campbell H, Wild SH, Wilson JF, Gläser S, Homuth G, Völzke H, Mangino M, Soranzo N, Spector TD, Polasek O, Rudan I, Wright AF, Heliövaara M, Ripatti S, Pouta A, Naluai AT, Olin AC, Torén K, Cooper MN, James AL, Palmer LJ, Hingorani AD, Wannamethee SG, Whincup PH, Smith GD, Ebrahim S, McKeever TM, Pavord ID, MacLeod AK, Morris AD, Porteous DJ, Cooper C, Dennison E, Shaheen S, Karrasch S, Schnabel E, Schulz H, Grallert H, Bouatia-Naji N, Delplanque J, Froguel P, Blakey JD; NSHD Respiratory Study Team, Britton JR, Morris RW, Holloway JW, Lawlor DA, Hui J, Nyberg F, Jarvelin MR, Jackson C, Kähönen M, Kaprio J, Probst-Hensch NM, Koch B, Hayward C, Evans DM, Elliott P, Strachan DP, Hall IP, Tobin MD. Nature Genetics. Jan;42(1):36-44. PubMed
A biomechanical model of agonist-initiated contraction in the asthmatic airway.
Brook BS, Peel SE, Hall IP, Politi AZ, Sneyd J, Bai Y, Sanderson MJ, Jensen OE.
Respir Physiol Neurobiol. 2010 Jan 31;170(1):44-58. PubMed
2009
Mechanisms of Action of β2-Adrenoceptor Agonists (2009) Sayers I & Hall IP. Allergy Frontiers: Epigenetics, Allergens and Risk Factors.
PLAUR polymorphisms and lung function in UK smokers (2009) Stewart CE, Hal lIP, Parker SG, Moffatt MF, Wardlaw AJ, Connolly MJ, Ruse C & Sayers I. BMC Medical Genetics Oct 31;10:112. PubMed
Characterisation of urokinase plasminogen activator receptor variants in human airway and peripheral cells (2009) Stewart CE & Sayers I. BMC Mol Biol. 10:75. PubMed
PLAUR polymorphisms are associated with asthma, PLAUR levels and lung function decline (2009) Barton SJ, Koppelman GH, Vonk JM, Browning CA, Nolte IM, Stewart CE, Bainbridge S, Mutch S, Rose-Zerilli MJ, Postma DS, Maniatis N, Henry AP, Hall IP, Holgate ST, Tighe P, Holloway JW, Sayers I. JACI 123:1406-15 . PubMed
Pharmacogenetic characterisation of Indacaterol, a novel β2-adrenoceptor agonist (2009) Sayers I, Hawley J, Stewart CE, Billington CK, Henry A, Leighton-Davies JR, Charlton SJ, Hall IP. British Journal of Pharmacology 158,277–286 . PubMed
Clements D, Chang YCW, Johnson SR. Lymphangioleiomyomatosis: bench to bedside. European Respiratory Monograph. 2009 in press.
Blakey JD, Sayers I, Ring SM, Strachan DP & Hall IP. Positionally cloned asthma susceptibility gene polymorphism and disease risk in the British 1958 birth cohort. Thorax. 2009 64(5):381-7. PubMed
Duroudier NP, Tulah AS & Sayers I. Leukotriene pathway genetics and pharmacogenetics in allergy. Allergy. 2009 64(6):823-39. PubMed
2008
Clements D, Asprey SL, Morris TA, Magowan L, McCulloch TA, Watson SA and Johnson SR. Analysis of the oestrogen response in an angiomyolipoma derived xenograft model. Endocrine Related Cancer. 2008 16(1):59-72. PubMed
Cohen MM, Freyer AM, Johnson SR. Pregnancy experiences among women with lymphangioleiomyomatosis. Respiratory Medicine. 2008, 103(5):766-72. PubMed
Sayers I & Hall IP. Genetic and Molecular Regulation of β2-adrenergic receptors. Allergy Frontiers: Epigenetics, Allergens and risk Factors. 2008 Vol 1, 2005-225.
Holloway JW, Barton SJ, Holgate ST, Rose-Zerelli MJ & Sayers I. The role of LTA4H and ALOX5AP polymorphism in Asthma and Allergy. Allergy. 2008 63(8):1046-1053. PubMed
Aslam A, Lewis R, Wheatley A, Pleass RJ & Sayers I. The secretory tailpiece isoform of IgE is not associated with Allergy. Allergy. 2008 63(7):942-943. PubMed
Burgess JK, Schuliga M, Ward J, Moir LM, Kanabar V, Johnson SR, Ceresa CC, Oliver BGG, Nguyen TBB. Tissue and matrix influences on airway smooth muscle function. Pulmonary Pharmacology and Therapeutics. 2008, 22(5):379-87. PubMed
Davies DM, Johnson SR, Tattersfield A, Kingswood JC, Cox JA, McCartney DL, Doyle T, Elmslie F, Saggar A, de Vries P, Sampson JR. Sirolimus therapy for renal angiomyolipoma in patients with tuberous sclerosis or sporadic lymphangioleiomyomatosis. New England Journal of Medicine 2008 10:358(2):200-3. PubMed
Denham S, Koppelman G, Blakey B, Wjst M, Ferreira MA, Hall IP & Sayers I. Meta-analysis of genome-wide linkage studies of asthma and related traits. Respiratory Research. 2008 9:38. PubMed
Hall IP. Natriuretic peptides and asthma: is there a connection? Clin Exp Allergy 2008, 38(7):1068-70. PubMed
Peel SE, Lui B & Hall IP. ORAI and store-operated calcium influx in human airway smooth muscle cells. Am J Respir Cell Mol Biol 2008 38(6):744-9. PubMed
Singh SR & Hall IP. Airway myofibroblasts and their relationship with myocytes and fibroblasts. Proc Am Thorsc Soc 2008 5(1) 127-32. PubMed
Billington CK, Le Jeune IR, Young KW & Hall IP. A major functional role for phosphodiesterase 4D5 in human airway smooth muscle cells. Am J Respuir Cell Mol Biol 2008 38(1):1-7. PubMed
Panettieri RA, Kotlikoff MI, Gerthoffer WT, Hershenson MB, Woodruff PG, Hall IP & Banks-Schlegel S. Airway smooth muscle in bronchial tone, inflammation and remodelling: basic knowledge to clinical relevance. Am J Respir Crit Care Med 2008 177(3):248-52. PubMed
Lowrey GE, Henderson N, Blakey JD, Corne JM and Johnson SR. MMP-9 protein level does not reflect overall MMP activity in the airways of patients with COPD. Respiratory Medicine 2008 102(6)845-51. PubMed
2007
Pollock-BarZiv SM, Cohen MM, Downey GP, Johnson SR, Sullivan E, McCormack FX. Air travel in women with Lymphangioleiomyomatosis. Thorax 2007;62:176-180. PubMed
Johnson SR Management of Rare Diseases in Respiratory Medicine. Clinical Medicine 2007;7:447–8. PubMed
Johnson SR. Lymphangioleiomyomatosis. In Diffuse Parenchymal Lung Disease: Progress in Respiratory Research (volume 36). Karger. 2007: Editors U Costabel, RM DuBois, JJ Egan.
Smith N, Brown CA, Duroudier N, Stewart C, Peel S, Swan C, Hall IP & Sayers I. Salmeterol and cytokines modulate inositol-phosphate signalling in Human airway smooth muscle cells via regulation at the receptor locus. Respiratory Research.2007 28:8(1):68. PubMed
Taylor DR & Hall IP. ADRB2 polymorphisms and beta2 agonists. Lancet 2007 22;370(9605):2075-6. PubMed
Konstantinidis AK, Barton SJ, Sayers I, Yang IA, Lordan JL, Rorke S, Clough JB, Holgate ST, Holloway JW. Genetic association studies of interleukin-13 receptor {alpha}1 subunit gene polymorphisms in asthma and atopy. Eur Respir J. 2007 Jul;30(1):1326-33. PubMed
Hidalgo-Bastida LA, Barry JJ, Everitt NM, Rose FR, Buttery LD, Hall IP, Claycomb WC, Shakesheff KM. Cell adhesion and mechanical properties of a flexible scaffold for cardiac tissue engineering. Acta Biomater. 2007 Jul;3(4):457-62. PubMed
Jame AJ, Lackie PM, Cazaly AM, Sayers I, Penrose JF, Holgate ST, Sampson AP. Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4. Clin Exp Allergy. 2007 Jun;37(6):880-92. PubMed
Hall IP, Sayers I. Pharmacogenetics and asthma: false hope or new dawn? Eur Respir J. 2007 Jun;29(6):1239-45. PubMed
Liu B, Freyer AM, Hall IP. Bradykinin activates calcium-dependent potassium channels in cultured human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2007 Apr;292(4):L898-907. PubMed
Henderson N, Markwick LJ, Elshaw SR, Freyer AM, Knox AJ, Johnson SR. Collagen I and thrombin activate MMP-2 by MMP-14-dependent and -independent pathways: implications for airway smooth muscle migration. Am J Physiol Lung Cell Mol Physiol. 2007 Apr;292(4):L1030-8. PubMed
Clements D, Mayer RJ, Johnson SR. Subcellular distribution of the TSC2 gene product tuberin in human airway smooth muscle cells is driven by multiple localization sequences and is cell-cycle dependent. Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L258-66. PubMed
Duroudier NP, Sayers I, Castagna CC, Fenech AG, Halapi E, Swan C, Hall IP.
Functional Polymorphism and Differential Regulation of CYSLTR1 Transcription in Human Airway Smooth Muscle and Monocytes. Cell Biochem Biophys. 2007;47(1):119-30. PubMed
Back to Division of Therapeutics & Molecular Medicine