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School of Clinical Sciences
   
   
  
 

Alexey Ruzov

Lecturer in Stem Cell Biology, Faculty of Medicine & Health Sciences

Contact

  • workRoom Room A59 Centre for Biomolecular Sciences
    University Park
    Nottingham
    NG7 2RD
    UK
  • work0115 8231234
  • fax0115 8231230

Biography

Education

  • 2000 Institute of Gene Biology, Russian Academy of Sciences, Moscow Ph.D. in Molecular Genetics entitled "Transcriptional regulation of tag7/PGRP gene in different model systems."
  • 1996 Lomonosov's Moscow State University, Biological Faculty Department of Bioorganic Chemistry. MSc in Biochemistry. Honours diploma.

Career

  • Feb 2011 - Present time: Lecturer in Stem Cell Biology, Wolfson Centre for Stem Cells, Tissue Engineering and Modelling (STEM), Centre for Biomolecular Sciences, University of Nottingham, Nottingham, UK.
  • Feb 2009 - Jan 2011: Research Fellow, Scottish Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.
  • Jul 2008 - Jul 2009: Research Fellow, Institute of Genetics and Molecular Medicine (IGMM), Cancer Research Centre, Edinburgh, UK.
  • Jun 2004 - Apr 2008: Carrier Development Fellow, IGMM, Medical Research Council Human Genetics Unit (MRC HGU), Edinburgh, UK.
  • Feb 2001 - Aug 2003: Wellcome Trust Travelling Research Fellow, Dept. of Biomedical Sciences, University of Edinburgh, UK. Working with Dr. Richard Meehan on "The role of methyl-CpG binding protein Kaiso in Xenopus development"..
  • Mar 1998 - Aug 1998: Recipient of short-term fellowship, ICGEB, Trieste, Italy.
  • Mar 1998 - May 2000: Ph.D. student, Group of Transcriptional Control and Oncogenesis, Institute of Gene Biology, Moscow, Russia.

Expertise Summary

Technical skills

  • Molecular biology techniques,
  • DNA-protein interactions techniques,
  • cell biology techniques,
  • developmental biology expertise (early mouse development, Xenopus laevis).

Teaching Summary

Module Convenor for the Cell, Developmental and Molecular Biology module of the MSc in Stem Cell Technology

Recent Publications

  • D ALMEIDA R, SOTTILE V, LOOSE M, DE SOUSA P, JOHNSON AJ and RUZOV A, 2012. Semi-quantitative immunohistochemical detection of 5-hydroxymethylcytosine reveals conservation of its tissue distribution between amphibians and mammals. Epigenetics. 7(2), (In Press.)
  • D ALMEIDA R, LOOSE M, SOTTILE V, MATSA E, DENNING C, YOUNG L, JOHNSON AJ, GERING M and RUZOV A, 2012. 5-Hydroxymethyl-cytosine enrichment of non-committed cells is not a universal feature of vertebrate development. Epigenetics. 7(4), (In Press.)
  • RUZOV A, TSENKINA Y, SERIO A, DUDNAKOVA T, FLETCHER J, BAI Y, CHEBOTAREVA T, PELLS S, HANNOUN Z, SULLIVAN G, CHANDRAN S, HAY D, BRADLEY M, WILMUT I, DE SOUSA, PA, 2011. Lineage specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development. Cell Research. 21, 1332–1342.
  • NESTOR, COLM, RUZOV, ALEXEY, MEEHAN, RICHARD and DUNICAN, DONNCHA, 2010. Enzymatic approaches and bisulfite sequencing cannot distinguish between 5-methylcytosine and 5-hydroxymethylcytosine in DNA. BioTechniques. 48(4), 317-9
  • RUZOV, ALEXEY, SAVITSKAYA, EKATERINA, HACKETT, JAMIE A, REDDINGTON, JAMES P, PROKHORTCHOUK, ANNA, MADEJ, MONIKA J, CHEKANOV, NIKOLAI, LI, MINGHUI, DUNICAN, DONNCHA S, PROKHORTCHOUK, EGOR and PENNINGS, SA, 2009. The non-methylated DNA-binding function of Kaiso is not required in early Xenopus laevis development. Development (Cambridge, England). 136(5), 729-38
  • RUZOV, ALEXEY, HACKETT, JAMIE A, PROKHORTCHOUK, ANNA, REDDINGTON, JAMES P, MADEJ, MONIKA J, DUNICAN, DONNCHA S, PROKHORTCHOUK, EGOR, PENNINGS, SARI and MEEHAN, RICHARD R, 2009. The interaction of xKaiso with xTcf3: a revised model for integration of epigenetic and Wnt signalling pathways. Development (Cambridge, England). 136(5), 723-7
  • RUZOV, ALEXEY, SHORNING, BORIS, MORTUSEWICZ, OLIVER, DUNICAN, DONNCHA S, LEONHARDT, HEINRICH and MEEHAN, RICHARD R, 2009. MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos. Development (Cambridge, England). 136(13), 2277-86
  • DUNICAN, DONNCHA S, RUZOV, ALEXEY, HACKETT, JAMIE A and MEEHAN, RICHARD R, 2008. xDnmt1 regulates transcriptional silencing in pre-MBT Xenopus embryos independently of its catalytic function. Development (Cambridge, England). 135(7), 1295-302
  • MEEHAN, RICHARD R, DUNICAN, DONNCHA S, RUZOV, ALEXEY and PENNINGS, SARI, 2005. Epigenetic silencing in embryogenesis. Experimental cell research. 309(2), 241-9
  • RUZOV, ALEXEY S, MERTSALOV, ILYA B, MEEHAN, RICHARD, KISELEV, SERGEY L, BUCHMAN, VLADIMIR L and KOROBKO, IGOR V, 2004. Cloning and developmental expression of MARK/Par-1/MELK-related protein kinase xMAK-V in Xenopus laevis. Development genes and evolution. 214(3), 139-43
  • RUZOV, ALEXEY, DUNICAN, DONNCHA S, PROKHORTCHOUK, ANNA, PENNINGS, SARI, STANCHEVA, IRINA, PROKHORTCHOUK, EGOR and MEEHAN, RICHARD R, 2004. Kaiso is a genome-wide repressor of transcription that is essential for amphibian development. Development (Cambridge, England). 131(24), 6185-94
  • ALIPOV, E D, TYRSINA, E G, SARIMOV, R M, RUZOV, A S and PROKHORTSUK, E B, 2004. [Acquired radioresistance of progeny of irradiated cells is accompanied by rearrangements in chromatin organization]. Radiatsionnaia biologiia, radioecologiia / Rossiĭskaia akademiia nauk. 44(2), 188-97
  • PROKHORTCHOUK, A, HENDRICH, B, JØRGENSEN, H, RUZOV, A, WILM, M, GEORGIEV, G, BIRD, A and PROKHORTCHOUK, E, 2001. The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor. Genes & development. 15(13), 1613-8
  • SMIRNOV, A S, RUZOV, A S, BUDANOV, A V, PROKHORTCHOUK, A V, IVANOV, A V and PROKHORTCHOUK, E B, 2001. High constitutive level of NF-kappaB is crucial for viability of adenocarcinoma cells. Cell death and differentiation. 8(6), 621-30
  • PROKHORCHUK, A V, AĬTKHOZHINA, D S, SABLINA, A A, RUZOV, A S and PROKHORCHUK, E B, 2001. [KAISO--a new member of the BTB/POZ family specifically bindsto methylated DNA sequences]. Genetika. 37(6), 737-44
  • SMIRNOV, A S, BUDANOV, A V, RUZOV, A S, IVANOV, A V, PROKHORCHUK, A V, GNUCHEV, N V and PROKHORCHUK, E B, 2000. [A high constitutive level of NF-kappa B is necessary for viability of murine adenocarcinoma cells--possible role of p53]. Molekuliarnaia biologiia. 34(5), 775-82
  • SMIRNOV, A S, RUZOV, A S, GNUCHEV, N V and PROKHORCHUK, E B, 2000. Mechanisms maintaining high constitutive levels of NF-kappa B in murine adenocarcinoma cells. Doklady biochemistry : proceedings of the Academy of Sciences of the USSR, Biochemistry section / translated from Russian. 373(1-6), 148-9
  • RUZOV, A S, GEORGIEV, G P and PROKHORCHUK, E B, 2000. [Functional characteristics of the promoter region of the tag7/PGRP gene in KSML0, KSML100 murine mammary adenocarcinoma cell ines and VMR liver]. Genetika. 36(5), 636-43
  • PROKHORCHUK, A V and RUZOV, A S, 2000. [Genome methylation and its role in functioning of the eukaryotic organism]. Genetika. 36(11), 1475-86
  • PROKHORTCHOUK, E B, PROKHORTCHOUK, A V, ROUZOV, A S, KISELEV, S L, LUKANIDIN, E M and GEORGIEV, G P, 1998. A minisatellite "core" element constitutes a novel, chromatin-specific activator of mts1 gene transcription. Journal of molecular biology. 280(2), 227-36
  • AKOPOV, S B, NIKOLAEV, L G, TYRSIN OYU,, RUZOV, A S and SVERDLOV, E D, 1997. [14 sequences from Chinese hamster genome preferentially binding to the nuclear matrix]. Bioorganicheskaia khimiia. 23(9), 727-31

School of Clinical Sciences

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Queen's Medical Centre
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